Serotonin-induced nitric oxide production in the ventral nerve cord of the earthworm, Eisenia fetida.

Abstract:

:Effect of serotonin on nitric oxide (NO) production in the ventral nerve cord (VNC) of the earthworm Eisenia fetida was investigated by a bio-imaging and an electrochemical technique. In the bio-imaging, the spatial pattern of NO production in VNC was visualized using an NO-specific fluorescent dye, diaminofluorescein-2 diacethyl (DAF-2 DA). Application of serotonin (100 microM) increased NO production in VNC by about 65% (P<0.05), compared with basal NO production. The increase was mainly from the nitergic neurons in the ventral side of VNC. In the electrochemical technique, real-time basal and serotonin-induced NO production was estimated with an NO-specific electrode. On the ventral surface of VNC, the estimated basal NO production was stable at 200+/-52 nM, and was transiently augmented to 840+/-193 nM by the addition of 10 microM serotonin. In conclusion, the estimated basal NO production in the earthworm VNC is relatively high compared with other nervous systems earlier reported, and transiently augmented by serotonin. Our results suggest that NO signaling in VNC is involved in neuromodulation by serotonin.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Kitamura Y,Naganoma Y,Horita H,Ogawa H,Oka K

doi

10.1016/s0168-0102(01)00271-1

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

129-34

issue

2

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(01)00271-1

journal_volume

41

pub_type

杂志文章
  • Proline repeats, in cis- and trans-positions, confer protection against the toxicity of misfolded proteins in a mammalian cellular model.

    abstract::A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2011.05.001

    authors: Siwach P,Sengupta S,Parihar R,Ganesh S

    更新日期:2011-08-01 00:00:00

  • Subcortical vascular dementia.

    abstract::Subcortical vascular dementia (SVD) is a small vessel disease with dementia that exhibits relatively uniform clinical and pathological features and constitutes approximately half of vascular dementia (VaD) cases. This subtype is further classified into Binswanger's disease and multiple lacunar infarctions. The former ...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2011.07.1820

    authors: Tomimoto H

    更新日期:2011-11-01 00:00:00

  • Organization of the main olfactory bulb of lesser hedgehog tenrecs.

    abstract::Using a confocal laser scanning microscope (CLSM) and an electron microscope, we investigated the organization of the main olfactory bulb (MOB) of tenrecs, which were previously included into insectivores but now considered to be in a new order "Afrosoricida" in the superclade 'Afrotheria'. We confirmed that the overa...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2005.08.004

    authors: Kosaka K,Künzle H,Kosaka T

    更新日期:2005-12-01 00:00:00

  • Intracellular Ca2+-dependent and Ca2+-independent responses of rat brain serotonin receptors transplanted to Xenopus oocytes.

    abstract::Xenopus oocytes injected with messenger RNA extracted from rat brain are induced to acquire a variety of neurotransmitter receptors and voltage-operated membrane channels. Activation of the receptors to serotonin, acetylcholine (muscarinic) and glutamate elicits oscillatory membrane currents carried by chloride ions. ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(85)90021-5

    authors: Parker I,Gundersen CB,Miledi R

    更新日期:1985-08-01 00:00:00

  • Functions of glutamate transporters in the brain.

    abstract::L-glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system and has also been implicated as a potent neurotoxin. To ensure a high signal-to-noise ratio during synaptic transmission and to prevent neuronal damage that might occur as a result of excessive activation of glutamate recept...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/s0168-0102(00)00104-8

    authors: Tanaka K

    更新日期:2000-05-01 00:00:00

  • Adaptive ability to cope with atypical or novel situations involving tool use: an fMRI approach.

    abstract::We investigated the neural mechanisms underlying the ability to cope in atypical or novel situations using tools. We hypothesized that two cognitive components support this ability: adaptive coordination (for adapting to situational demands) and cognitive inhibition (for inhibiting the incongruent actions afforded by ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2014.03.008

    authors: Wakusawa K,Sugiura M,Sassa Y,Jeong H,Yomogida Y,Horie K,Sato S,Yokoyama H,Kure S,Takei N,Mori N,Kawashima R

    更新日期:2015-01-01 00:00:00

  • Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons.

    abstract::We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.03.016

    authors: Ye R,Li N,Han J,Kong X,Cao R,Rao Z,Zhao G

    更新日期:2009-07-01 00:00:00

  • Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain.

    abstract::Chemokines are a family of peptides originally identified as the factors regulating the migration of leukocytes in inflammatory and immune responses. Recently, they have been shown to be produced in the central and peripheral nervous systems under various pathological conditions and act on neuronal and glial cells. In...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2004.01.004

    authors: Tanaka T,Minami M,Nakagawa T,Satoh M

    更新日期:2004-04-01 00:00:00

  • Effects of lamotrigine on behavior, oxidative parameters and signaling cascades in rats exposed to the chronic mild stress model.

    abstract::The rats were subjected to 40 days of stress protocol, during which the sucrose consumption was assessed in rats chronically treated with lamotrigine (20mg/kg) or with saline. The signaling cascade and oxidative stress parameters were assessed in the brain rat. Both control and stressed rats treated with lamotrigine s...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2013.02.002

    authors: Abelaira HM,Réus GZ,Ribeiro KF,Steckert AV,Mina F,Rosa DV,Santana CV,Romano-Silva MA,Dal-Pizzol F,Quevedo J

    更新日期:2013-04-01 00:00:00

  • Unmasking of silent "task-related" neuronal activity in the monkey prefrontal cortex by a GABA(A) antagonist.

    abstract::To examine the role of GABA on prefrontal neuronal activity in the control of behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was iontophoretically applied to prefrontal neurons while monkeys performed a visual reaction time task. Iontophoretic application of BMI uncovered "task-related" activit...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(00)00204-2

    authors: Sawaguchi T

    更新日期:2001-01-01 00:00:00

  • Ca2+ -activated K+ current at presynaptic terminals of goldfish retinal bipolar cells.

    abstract::Properties of the Ca2+ -activated K+ current (I[K(Ca)]) were investigated in bipolar cells isolated from the goldfish retina. Pharmacological experiments and single channel current recordings demonstrated that I[K(Ca)] represented currents through BK channels, which were confined mostly to the presynaptic terminal. Th...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)01155-3

    authors: Sakaba T,Ishikane H,Tachibana M

    更新日期:1997-03-01 00:00:00

  • Reactive astrocytes in Alzheimer's disease: A double-edged sword.

    abstract::Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late stage cannot be easily reversed. Because AD progression is caused by multiple factors including diverse cellular processes, studies on AD pathogenesis at the molecular and cellular level are challenging. Based on the lessons ...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2017.11.012

    authors: Chun H,Lee CJ

    更新日期:2018-01-01 00:00:00

  • Increased brain activation during motor imagery suggests central abnormality in Neonatal Brachial Plexus Palsy.

    abstract::Neonatal Brachial Plexus Palsy (NBPP) may lead to permanent impairment of arm function. As NBPP occurs when central motor programs develop, these may be ill-formed. We studied elbow flexion and motor imagery with fMRI to search for abnormal motor programming. We compared the cortical activity of adults with conservati...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2017.05.001

    authors: Anguelova GV,Rombouts SARB,van Dijk JG,Buur PF,Malessy MJA

    更新日期:2017-10-01 00:00:00

  • Distribution of neurofilament proteins and peripherin in the rat pituitary gland.

    abstract::The distribution of neurofilament proteins and peripherin in the pituitary gland of the rat was studied with a panel of monoclonal and polyclonal antibodies recognizing different neurofilament subunits. In the posterior lobe, a dense plexus of neurofilament- and peripherin-immunoreactive fibers was seen. In the interm...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(95)00903-7

    authors: Bäck N,Tyynelä M,Portier MM,Virtanen I,Soinila S

    更新日期:1995-06-01 00:00:00

  • Effects of trans-2,4-dimethoxystibene against the neurotoxicity induced by Abeta(25-35) both in vitro and in vivo.

    abstract::Trans-2,4-dimethoxystibene (S(3)) is a synthetic stilbene. In this study, S(3) was investigated in terms of its neuroprotective effect against the toxicity induced by beta-amyloid(25-35) (Abeta(25-35)) both in vitro and in vivo. Protection by S(3) was studied at the in vivo level using a model of intracerebroventricul...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2010.03.009

    authors: Ruan CJ,Zhang L,Chen DH,Li Z,Du GH,Sun L

    更新日期:2010-07-01 00:00:00

  • Intraretinal axons of ganglion cells in the Japanese monkey (Macaca fuscata): conduction velocity and diameter distribution.

    abstract::In anesthetized and immobilized Japanese monkeys (Macaca fuscata), intraretinal conduction velocities of the ganglion cell axons were measured. The field potentials elicited by optic chiasm shocks consisted of fast and slow components with estimated conduction velocities of 1.19 and 0.72 m/s in recordings from the opt...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(88)90006-5

    authors: Fukuda Y,Watanabe M,Wakakuwa K,Sawai H,Morigiwa K

    更新日期:1988-10-01 00:00:00

  • Evidence that the serotonin transporter does not shift into the cytosol of remaining neurons after neonatal brain injury.

    abstract::Following neonatal hypoxia-ischemia (HI) serotonin (5-hydroxytryptamine, 5-HT) levels are decreased in the brain. The regulation of brain 5-HT is dependent on the serotonin transporter (SERT) localised at the neuronal pre-synaptic cell membrane. However SERT can also traffic away from the cell membrane into the cytoso...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2012.04.002

    authors: Wixey JA,Reinebrant HE,Buller KM

    更新日期:2012-07-01 00:00:00

  • Role of growth hormone (GH) in the treatment on neural diseases: from neuroprotection to neural repair.

    abstract::Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In ...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2013.03.014

    authors: Arce VM,Devesa P,Devesa J

    更新日期:2013-08-01 00:00:00

  • Somatic noxious mechanical stimulation induces Fos expression in the postsynaptic dorsal column neurons in laminae III and IV of the rat spinal dorsal horn.

    abstract::This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(01)00245-0

    authors: Day AS,Wen CY,Shieh JY,Sun WZ,Lue JH

    更新日期:2001-08-01 00:00:00

  • The effect of education on regional brain metabolism and its functional connectivity in an aged population utilizing positron emission tomography.

    abstract::Education involves learning new information and acquiring cognitive skills. These require various cognitive processes including learning, memory, and language. Since cognitive processes activate associated brain areas, we proposed that the brains of elderly people with longer education periods would show traces of rep...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2014.12.009

    authors: Kim J,Chey J,Kim SE,Kim H

    更新日期:2015-05-01 00:00:00

  • Encoding-related brain activity during deep processing of verbal materials: a PET study.

    abstract::The recent advent of neuroimaging techniques provides an opportunity to examine brain regions related to a specific memory process such as episodic memory encoding. There is, however, a possibility that areas active during an assumed episodic memory encoding task, compared with a control task, involve not only areas d...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(02)00160-8

    authors: Fujii T,Okuda J,Tsukiura T,Ohtake H,Suzuki M,Kawashima R,Itoh M,Fukuda H,Yamadori A

    更新日期:2002-12-01 00:00:00

  • Calcium-binding protein, secretagogin, characterizes novel groups of interneurons in the rat striatum.

    abstract::In the rat striatum numerous secretagogin (SCGN) positive neurons were scattered. They were heterogeneous in their morphological and chemical properties. We examined the colocalization of SCGN with known four interneuron markers, parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and choline acetyl transfe...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2017.01.004

    authors: Kosaka T,Yasuda S,Kosaka K

    更新日期:2017-06-01 00:00:00

  • Distribution of serotonin cells projecting to the pontomedullary reticular formation in the cat.

    abstract::Using immunohistochemistry and retrograde transport techniques, this study demonstrates that serotonin (5-HT) cells in the dorsal tegmental gray of the pons at rostrocaudal from P1 to P6 levels are sources of bilateral serotonergic projections to the gigantocellular tegmental field of the medial pontine and medullary ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(94)90021-3

    authors: Kobayashi Y,Matsuyama K,Mori S

    更新日期:1994-07-01 00:00:00

  • Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic substrates.

    abstract::Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2019.07.003

    authors: Bernstein DL,Nayak SU,Oliver CF,Rawls SM,Rom S

    更新日期:2020-06-01 00:00:00

  • Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteins.

    abstract::Opiates have been used extensively in the treatment of pain but with the severe side effect of addiction, which is believed to be related to opiates' direct (primary) or indirect (secondary) neurotoxicity. In this study, the effects of opioids on cell growth and apoptosis have been examined in human neuroblastoma cell...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)00080-1

    authors: Yin DL,Ren XH,Zheng ZL,Pu L,Jiang LZ,Ma L,Pei G

    更新日期:1997-10-01 00:00:00

  • GABAergic input contributes to activity-dependent change in cell volume in the hippocampal CA1 region.

    abstract::Swelling of brain cells is one of the physiological responses associated with neuronal activation. To investigate underlying mechanisms, we analyzed interactions between changes in cell volume and synaptic responses in the hippocampal slices from rodents. Swelling within the CA1 area was detected as increases in trans...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(02)00153-0

    authors: Takagi S,Obata K,Tsubokawa H

    更新日期:2002-11-01 00:00:00

  • Alteration of a motor learning rule under mirror-reversal transformation does not depend on the amplitude of visual error.

    abstract::Human's sophisticated motor learning system paradoxically interferes with motor performance when visual information is mirror-reversed (MR), because normal movement error correction further aggravates the error. This error-increasing mechanism makes performing even a simple reaching task difficult, but is overcome by ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2014.12.010

    authors: Kasuga S,Kurata M,Liu M,Ushiba J

    更新日期:2015-05-01 00:00:00

  • Carnosine: effect on aging-induced increase in brain regional monoamine oxidase-A activity.

    abstract::Aging is a natural biological process associated with several neurological disorders along with the biochemical changes in brain. Aim of the present investigation is to study the effect of carnosine (0.5-2.5μg/kg/day, i.t. for 21 consecutive days) on aging-induced changes in brain regional (cerebral cortex, hippocampu...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2014.09.009

    authors: Banerjee S,Poddar MK

    更新日期:2015-03-01 00:00:00

  • Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia.

    abstract::The synthesis of glial-fibrillary acidic protein (GFAP) or the re-expression of progenitor markers such as Nestin increases in reactive astrocytes after brain ischemia. We investigated the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-bindin...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.12.013

    authors: Oki K,Kaneko N,Kanki H,Imai T,Suzuki N,Sawamoto K,Okano H

    更新日期:2010-04-01 00:00:00

  • Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain.

    abstract::ATP-sensitive K(+) (K(ATP)) channel subunits SUR2A and SUR2B in the rat brain were investigated by RT-PCR assay, western blot analysis, in situ hybridization histochemistry, and immunohistochemical staining. The results show that the mRNA and protein of SUR2A and SUR2B are expressed in whole rat brain extracts and sel...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2012.08.005

    authors: Zhou M,He HJ,Tanaka O,Sekiguchi M,Kawahara K,Abe H

    更新日期:2012-10-01 00:00:00