Abstract：
:Effect of serotonin on nitric oxide (NO) production in the ventral nerve cord (VNC) of the earthworm Eisenia fetida was investigated by a bio-imaging and an electrochemical technique. In the bio-imaging, the spatial pattern of NO production in VNC was visualized using an NO-specific fluorescent dye, diaminofluorescein-2 diacethyl (DAF-2 DA). Application of serotonin (100 microM) increased NO production in VNC by about 65% (P<0.05), compared with basal NO production. The increase was mainly from the nitergic neurons in the ventral side of VNC. In the electrochemical technique, real-time basal and serotonin-induced NO production was estimated with an NO-specific electrode. On the ventral surface of VNC, the estimated basal NO production was stable at 200+/-52 nM, and was transiently augmented to 840+/-193 nM by the addition of 10 microM serotonin. In conclusion, the estimated basal NO production in the earthworm VNC is relatively high compared with other nervous systems earlier reported, and transiently augmented by serotonin. Our results suggest that NO signaling in VNC is involved in neuromodulation by serotonin.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Kitamura Y,Naganoma Y,Horita H,Ogawa H,Oka Kdoi
10.1016/s0168-0102(01)00271-1subject
Has Abstractpub_date
2001-10-01 00:00:00pages
129-34issue
2eissn
0168-0102issn
1872-8111pii
S0168-0102(01)00271-1journal_volume
41pub_type
杂志文章abstract：:Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...
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pub_type： 杂志文章
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journal_title：Neuroscience research
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
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journal_title：Neuroscience research
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journal_title：Neuroscience research
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.12.009
更新日期：2015-05-01 00:00:00
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journal_title：Neuroscience research
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.11.005
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90101-4
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journal_title：Neuroscience research
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pub_type： 杂志文章
doi：10.1016/j.neures.2012.11.006
更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1994-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2017-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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