Abstract:
:Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral level in squirrel monkeys. Immunofluorescent studies revealed that, although SP+ fibers arborised more densely in the pars reticulata (SNr) than in the pars compacta (SNc), the two nigral divisions harbored numerous neurons expressing NK-1R and NK-3R. Confocal microscopic analyses showed that numerous SNr neurons and virtually all SNc dopaminergic neurons contained both NK-1R and NK-3R. At the electron microscope level, NK-1R and NK-3R were mainly associated with intracellular sites or located at extrasynaptic position on plasma membrane. A small proportion of SP+ boutons also showed NK-3R immunoreactivity. The distribution of NK-1R and NK-3R in SNr and SNc suggests that SP exerts its effect through postsynaptic receptors, as well as via presynaptic autoreceptors and heteroreceptors. These findings indicate that the excitatory peptide SP can modulate the inhibitory action of GABA at nigral level and suggest that the co-release of these two neuroactive substances should be taken into account when considering the functional organization of the basal ganglia.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Lévesque M,Wallman MJ,Parent R,Sík A,Parent Adoi
10.1016/j.neures.2006.11.002subject
Has Abstractpub_date
2007-03-01 00:00:00pages
362-71issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(06)00295-1journal_volume
57pub_type
杂志文章abstract::Prenatal exposure to nicotine (PNE) has been associated with a myriad of physiological, cognitive, and behavioral effects in the developing offspring. In this study, CD-1 dams were given injections of nicotine or control vehicle throughout gestation and their offspring were raised to 6 months of age. Adult mice were a...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2013.10.006
更新日期:2014-02-01 00:00:00
abstract::In an attempt to test the possibility that sino-aortic baroreceptors may mediate the previously reported stress response in hypothalamic magnocellular neurosecretory cell activity in rats, effects of deafferentation of sino-aortic baroreceptors on plasma levels of vasopressin and oxytocin after fear-related emotional ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(92)90059-l
更新日期:1992-04-01 00:00:00
abstract::To detect the release of nitric oxide (NO) in brain tissue, an electrochemical microprobe was developed. The output current of the probe correlated linearly with the NO concentration at the tip, and the sensitivity of the probe was between 3.5 and 106 pA per 1 microM change in NO concentration. This probe showed no se...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(90)90048-j
更新日期:1990-09-01 00:00:00
abstract::The 14-3-3 protein family consists of evolutionarily conserved, acidic 30 kDa proteins composed of seven isoforms named beta, gamma, epsilon, zeta, eta, theta, and sigma in mammalian cells. The dimeric complex of 14-3-3 isoforms, acting as a molecular adaptor, plays a central role in regulation of neuronal function. S...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.03.007
更新日期:2008-07-01 00:00:00
abstract::To investigate the representation of facial skin areas in the primary somatosensory cortex (SI), we recorded magnetic fields evoked by air pressure-induced tactile stimulation applied to six points on the face, lower lip and thumb. The thumb area in the SI was located more medial and superior to the lip area, which wa...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.07.004
更新日期:2004-10-01 00:00:00
abstract::Considerable evidence suggests that an N-methyl-D-aspartate (NMDA) receptor plays a crucial role in memory and cognitive function. To identify the role of this receptor in higher functions of the brain, we delivered antisense oligonucleotides against an NMDA-NR1 subunit (NR1) to the hippocampus in rats using the HVJ-l...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00012-9
更新日期:2003-04-01 00:00:00
abstract::The entopeduncular nucleus (EPN) is one of the major output nuclei of the basal ganglia in rodents. Previous studies have divided it into rostral and caudal halves, with the former containing somatostatin (SOM)-immunoreactive neurons and the latter dominated by parvalbumin (PV)-containing neurons, respectively. Howeve...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2015.02.006
更新日期:2015-05-01 00:00:00
abstract::We studied the patterns of membrane potential changes in vocal cord tensor motoneurons, i.e. cricothyroid muscle motoneurons (CTMs), during fictive breathing, vocalization, coughing, and swallowing in decerebrate paralyzed cats to determine the nature of central drives to CTMs during these behaviors. CTMs were identif...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.03.009
更新日期:2004-07-01 00:00:00
abstract::We examined effects of carbachol (CCh), muscarinic receptor agonist, on long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) at Schaffer collateral-CA1 synapse of guinea pig hippocampal slices using extracellular recording technique. Application of 0.1 microM CCh to the slices significantly ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(96)01147-9
更新日期:1997-02-01 00:00:00
abstract::To investigate the functional organization in the monkey inferotemporal cortex, which is the last exclusively visual area along the ventral visual cortical pathway, optical imaging based on intrinsic signals was carried out. We first conducted single-cell recordings with microelectrodes and determined the features cri...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00062-5
更新日期:1998-09-01 00:00:00
abstract::The adult human brain appears to have specialized and independent neural systems for the visual processing of faces and words: greater selectivity for faces in the right hemisphere (RH) while greater selectivity for words in the left hemisphere (LH). Nevertheless, the nature of functional differences between the hemis...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.11.006
更新日期:2020-07-01 00:00:00
abstract::Trans-2,4-dimethoxystibene (S(3)) is a synthetic stilbene. In this study, S(3) was investigated in terms of its neuroprotective effect against the toxicity induced by beta-amyloid(25-35) (Abeta(25-35)) both in vitro and in vivo. Protection by S(3) was studied at the in vivo level using a model of intracerebroventricul...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2010.03.009
更新日期:2010-07-01 00:00:00
abstract::Our previous research suggested that the P2X4 receptor (P2X4R) expression in microglia was involved in the activation of toll-like receptor-4 (TLR4) in the dorsal horn in the rat model of cancer induced bone pain (CIBP). In this study, we focused on whether TLR4- mitogen-activated protein kinases, p38 (p38 MAPK) contr...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2017.06.006
更新日期:2017-12-01 00:00:00
abstract::Reflex blinking provides a useful experimental tool for various functional studies on the peripheral and central nervous system, yet the neuronal circuitry underlying this reflex is not precisely known. In the present study, we investigated as to whether neurons in the reticular formation and rostral cervical spinal c...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.08.005
更新日期:2006-12-01 00:00:00
abstract::The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was gi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00063-9
更新日期:2002-08-01 00:00:00
abstract::After horseradish peroxidase was applied to the main trunk of the mouse vagal nerve, anterogradely labeled cells in the vagal ganglia and fibers in the solitary complex, and retrogradely labeled cells in the dorsal motor nucleus and the ambiguous nucleus were observed. Most of the cells in the nodose ganglion were lab...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(89)90018-7
更新日期:1989-12-01 00:00:00
abstract::The cerebellar Purkinje cell has highly branched dendrites extending in a transverse plane to the cerebellar folium. Branching patterns of the dendrites were subjected to fractal analysis to obtain a quantitative measure of their intricacy. Using a square-covering method, we found that dendrites have a statistical sel...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(92)90031-7
更新日期:1992-02-01 00:00:00
abstract::The disposition of the facial vibrissae of the mouse is represented as a matrix-like array of cell aggregates in rows and columns at every station of the whisker-to-barrel pathway. In order to evaluate the role of each station in this pathway, lesions were made in the facial vibrissae of the mystacial group on P0-P3, ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00969-Z
更新日期:1995-11-01 00:00:00
abstract::Effects of 1-naphthyl acetyl spermine (NASPM), a synthetic analogue of Joro spider toxin (JSTX), on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors were studied in cultured rat hippocampal neurons using the whole-cell patch clamp technique. A population of cultured neurons had ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00067-9
更新日期:1997-09-01 00:00:00
abstract::Neuronal circuits are intensively shaped depending on experiences received during developmental critical periods. How neuronal circuits are sculpted can even affect the later development of higher cognitive functions, such as vocal communication skills. Here, we propose songbirds that learn to sing from early auditory...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2018.11.002
更新日期:2019-03-01 00:00:00
abstract::The neural pathways underlying the respiratory responses elicited by electrical or chemical stimulation of the lateral part of the periaqueductal gray (lPAG) remain unsettled. In the present study, we examined the lPAG projection to neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons in the ventrolateral medulla ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.08.001
更新日期:2012-10-01 00:00:00
abstract::Recent technologies and developments in neuroscience have contributed to remarkable scientific discoveries, and have also raised many new philosophical, ethical, legal, and social issues. Research in "neuroethics" has identified various ethical issues, which will be difficult for current biomedical ethics to resolve f...
journal_title:Neuroscience research
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.neures.2006.09.004
更新日期:2007-01-01 00:00:00
abstract::Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in system...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.01.008
更新日期:2019-12-01 00:00:00
abstract::Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO). Hamster SCO consists of the ependymal and hypendymal cell layers, the latter being arranged as ro...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00185-8
更新日期:2003-09-01 00:00:00
abstract::We studied the ascending and descending axonal trajectories of excitatory vestibular neurons related to the anterior semicircular canal, by means of local stimulation and spike-triggered signal averaging techniques in anesthetized cats. More than 200 vestibular neurons related to the ampullary nerve of the anterior se...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(84)90036-1
更新日期:1984-10-01 00:00:00
abstract::Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie con...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2019.10.002
更新日期:2020-07-01 00:00:00
abstract::Social categorization plays an important role in provoking the victim's responses to aggressive interactions. Pioneering studies suggested that uncertainty in the perpetrator's hostile intention influences whether ingroup favoritism or the black sheep effect (ingroup strictness) will be manifested to a greater extent....
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2016.01.011
更新日期:2016-07-01 00:00:00
abstract::The distribution of neurofilament proteins and peripherin in the pituitary gland of the rat was studied with a panel of monoclonal and polyclonal antibodies recognizing different neurofilament subunits. In the posterior lobe, a dense plexus of neurofilament- and peripherin-immunoreactive fibers was seen. In the interm...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00903-7
更新日期:1995-06-01 00:00:00
abstract::Single units of the adrenal sympathetic nerve (n = 46) were dissected and characterized with respect to tonic discharge and response to cutaneous and baroreceptor stimulation. The frequency of tonic discharge averaged 1.6 Hz and cardiovascular rhythmic modulation was observed in 53% of the units. The stimuli employed ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(84)80008-5
更新日期:1984-04-01 00:00:00
abstract::Functional near-infrared spectroscopy (fNIRS) is a method of monitoring brain oxygenation. This technique investigates hemodynamic changes in the cerebral cortex. fNIRS is widely used in clinical and scientific research. In this review, we focus on the applications of fNIRS on neonates. Here, applications form two dis...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2020.11.003
更新日期:2020-12-30 00:00:00