Abstract：
:Prenatal exposure to nicotine (PNE) has been associated with a myriad of physiological, cognitive, and behavioral effects in the developing offspring. In this study, CD-1 dams were given injections of nicotine or control vehicle throughout gestation and their offspring were raised to 6 months of age. Adult mice were administered a battery of behavioral tests (the Suok test, the elevated platform test, and the elevated plus maze test) to assess anxiety and sensorimotor integration. PNE resulted in a decreased likelihood of jumping during the elevated platform test and decreased directed exploration in the Suok test, both indicative of increased anxiety. Also, PNE mice showed increased numbers of missteps while traversing an elevated rod in the Suok test, demonstrating altered sensorimotor integration. No significant differences were found in falls, segments traveled, latency to leave the central zone, vegetative responses, risk assessment behaviors, or autogroom behaviors. The elevated plus maze test revealed no significant differences between groups. No significant differences in body and brain weights, or cortical thickness within motor, somatosensory, and visual cortices were observed between PNE and control mice. Although neuroanatomical effects of PNE may be rescued as development progresses, defects in sensorimotor integration and increased anxiety persist into adulthood.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Santiago SE,Huffman KJdoi
10.1016/j.neures.2013.10.006subject
Has Abstractpub_date
2014-02-01 00:00:00pages
41-51eissn
0168-0102issn
1872-8111pii
S0168-0102(13)00228-9journal_volume
79pub_type
杂志文章abstract：:In the present study we measured cardiovascular and respiratory reflexes evoked by administration of bradykinin and capsaicin into the hindlimb vasculature of anaesthetised rats, whilst simultaneously recording activity of sensory afferents on the adventitial surface of femoral arteries and veins. Bradykinin (0.9 nmol...
journal_title：Neuroscience research
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abstract：:Huntington's disease (HD) is an autosomal dominant inheritable neurodegenerative disorder currently without effective treatment. It is caused by an expanded polyglutamine (poly Q) tract in the corresponding protein, huntingtin (htt), and therefore suppressing the huntingtin expression in brain neurons is expected to d...
journal_title：Neuroscience research
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journal_title：Neuroscience research
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doi：10.1016/j.neures.2005.06.010
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journal_title：Neuroscience research
pub_type： 杂志文章
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abstract：:Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of demyelination. MS is believed to be an autoimmune disorder mediated by activated immune cells such as T- and B-lymphocytes and...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
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doi：10.1016/j.neures.2008.01.007
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
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更新日期：1985-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00036-6
更新日期：2002-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00184-6
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.08.004
更新日期：2006-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.09.001
更新日期：2005-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.06.001
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.08.002
更新日期：2004-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90062-j
更新日期：1990-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.neures.2008.10.007
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.06.003
更新日期：2015-11-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00013-9
更新日期：1999-03-01 00:00:00
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更新日期：1992-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01068-1
更新日期：1996-08-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.02.002
更新日期：2007-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2003-06-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90082-a
更新日期：1991-05-01 00:00:00
abstract：:Adult neurogenesis is a process of generating new neurons from neural stem/precursor cells (NS/PCs) in restricted adult brain regions throughout life. It is now generally known that adult neurogenesis in the hippocampal dentate gyrus (DG) and subventricular zone participates in various higher brain functions, such as ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2018.05.007
更新日期：2019-06-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00159-0
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