Abstract：
:Damage to the central nervous system (CNS) leads to disruption of the vascular network, causing vascular dysfunction. Vascular dysfunction is the major event in the pathogenesis of CNS diseases and is closely associated with the severity of neuronal dysfunction. The suppression of vascular dysfunction has been considered a promising avenue to limit damage to the CNS, leading to efforts to clarify the cellular and molecular basis of vascular homeostasis maintenance. A reduction of trophic support and oxygen delivery due to circulatory insufficiency has long been regarded as a major cause of vascular damage. Moreover, recent studies provide a new perspective on the importance of the structural stability of blood vessels in CNS diseases. This updated article discusses emerging information on the key role of vascular integrity in CNS diseases, specially focusing on pericyte function.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Muramatsu R,Yamashita Tdoi
10.1016/j.neures.2014.01.007subject
Has Abstractpub_date
2014-04-01 00:00:00pages
38-41eissn
0168-0102issn
1872-8111pii
S0168-0102(14)00008-Xjournal_volume
81-82pub_type
杂志文章,评审abstract：:L-glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system and has also been implicated as a potent neurotoxin. To ensure a high signal-to-noise ratio during synaptic transmission and to prevent neuronal damage that might occur as a result of excessive activation of glutamate recept...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/s0168-0102(00)00104-8
更新日期：2000-05-01 00:00:00
abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.07.003
更新日期：2020-06-01 00:00:00
abstract：:We recorded 101 neurons in the nucleus of the optic tract (NOT) of 3 rhesus monkeys. The neurons were tested in a variety of oculomotor paradigms. This report focusses on the modulation of NOT neuronal activity during smooth pursuit eye movements. A small horizontally moving spot (less than 1 degrees) elicited a direc...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90103-6
更新日期：1991-10-01 00:00:00
abstract：:Cats were trained to reach to an illuminated tube placed horizontally at shoulder level and retrieve food with the forepaw. The trajectory of an infrared light emitting diode, taped to the wrist dorsum, was recorded with a SELSPOT-like recording system. Movement paths and velocity profiles were compared before and aft...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00093-x
更新日期：1997-11-01 00:00:00
abstract：:Experiments were performed to study the projection of the group y of the vestibular nuclei and the dentate and fastigial nuclei of the cerebellum to the interstitial nucleus of Cajal (INC) in cats by using retrograde axonal transport of horseradish peroxidase (HRP) and electrophysiological methods; and to study the ve...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(86)90021-0
更新日期：1986-05-01 00:00:00
abstract：:Catecholamine neurotransmitters--dopamine, noradrenaline (norepinephrine), adrenaline (epinephrine)--are synthesized in catecholaminergic neurons from tyrosine, via dopa, dopamine and noradrenaline, to adrenaline. Four enzymes are involved in the biosynthesis of adrenaline: (1) tyrosine 3-mono-oxygenase (tyrosine hydr...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(91)90001-f
更新日期：1991-10-01 00:00:00
abstract：:Amphibian metamorphosis is characterized by rapid tissue remodeling and drastic changes in the body structure and function. Like other organs, olfactory system also undergoes a dramatic rearrangement as the animal experiences transition from aquatic to terrestrial habitat. Reactive oxygen species (ROS) are known to pl...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.11.005
更新日期：2012-02-01 00:00:00
abstract：:Trauma to the spinal cord initiates a series of cellular and biochemical processes that damage both neurons and glia. TGF-beta and its receptors are expressed around the injury site following a spinal cord injury. Here, we report that the intrathecal administration of a neutralizing antibody to TGF-beta1 in rats with ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.08.017
更新日期：2009-12-01 00:00:00
abstract：:Until recently, little was known about the rostral part of the dorsal premotor cortex (PMdr). In the present study, somatotopical representations of the PMdr were electrophysiologically identified in the macaque monkey, and the distribution of corticostriatal input from the forelimb region of the PMdr was analyzed in ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.09.006
更新日期：2004-01-01 00:00:00
abstract：:Type B neurons of the bullfrog sympathetic ganglia were examined to confirm the existence of axon collaterals and the distribution of synaptic contacts using the intracellular horseradish peroxidase (HRP) labeling method. The mean diameter of the perikarya was 60.8 (+/- 11.5 standard deviation; n = 36) X 43.8 (+/- 11....
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90035-7
更新日期：1989-10-01 00:00:00
abstract：:The subthalamic nucleus occupies a position in the indirect pathway of basal ganglia circuit, which plays an important role in the movement regulation. Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA(A) receptors containing alpha 1 subunit. Recently, zolpidem has been rep...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.02.002
更新日期：2007-05-01 00:00:00
abstract：:Although sleep is strongly implicated in memory consolidation, the molecular basis for the role of sleep in memory is not known. It has been established that the consolidation of hippocampus-dependent memory depends on the activation of the Erk1,2 MAP kinase (MAPK) pathway which activates de novo CRE-mediated transcri...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2017.04.011
更新日期：2017-05-01 00:00:00
abstract：:The responses of slice-cultured Purkinje cells to trans-DL-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD) were examined by intracellular recording techniques and fura-2 microfluorometry. Bath-application of t-ACPD (100 microM, 30 s), a selective agonist of metabotropic glutamate receptors (mGluRs), to Purkinje cel...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90125-a
更新日期：1993-03-01 00:00:00
abstract：:This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.09.004
更新日期：2013-11-01 00:00:00
abstract：:Using Mayahara's method, the distribution of K(+)-dependent p-nitrophenylphosphatase activity was examined electron microscopically in the synaptic regions of the cerebral cortex of 10, 15 and 60-day-old Wistar rats. The enzyme achieved gradually its characteristic localization and uniform distribution. The main devel...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)01004-1
更新日期：1996-02-01 00:00:00
abstract：:Area TE sends dense projections to the perirhinal cortex in macaque monkeys, an area in which we previously observed flexible signals regarding upcoming reward outcomes during a conditional-association cued-reward task. To investigate neuronal processing during the generation of information on upcoming reward outcomes...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.08.004
更新日期：2014-11-01 00:00:00
abstract：:Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in system...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.01.008
更新日期：2019-12-01 00:00:00
abstract：:Neonatal Brachial Plexus Palsy (NBPP) may lead to permanent impairment of arm function. As NBPP occurs when central motor programs develop, these may be ill-formed. We studied elbow flexion and motor imagery with fMRI to search for abnormal motor programming. We compared the cortical activity of adults with conservati...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.05.001
更新日期：2017-10-01 00:00:00
abstract：:In lightly alpha-chloralose anaesthetized cats, activity was recorded simultaneously from 2-4 primary muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles. Increased tension in medial or lateral collateral ligament was found to evoke changes in the responses of the primary spi...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90066-8
更新日期：1991-06-01 00:00:00
abstract：:Many studies on long-term potentiation (LTP) in hippocampal region CA1 focus on receptor-mediated events that are often presumed to be linked to postsynaptic processes. Whereas it is now well-known that LTP consists of multiple components involving increases in postsynaptic responsiveness as well as enhanced presynapt...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00986-8
更新日期：1996-01-01 00:00:00
abstract：:Using immunohistochemistry and retrograde transport techniques, this study demonstrates that serotonin (5-HT) cells in the dorsal tegmental gray of the pons at rostrocaudal from P1 to P6 levels are sources of bilateral serotonergic projections to the gigantocellular tegmental field of the medial pontine and medullary ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90021-3
更新日期：1994-07-01 00:00:00
abstract：:Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Al...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.11.011
更新日期：2008-03-01 00:00:00
abstract：:In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00897-2
更新日期：1995-05-01 00:00:00
abstract：:To identify corticotropin releasing factor (CRF)- and galanin (GAL)-containing neurons projecting to the median eminence, a retrograde tracing method with True blue was combined with a double-staining method. It was demonstrated that some True blue-labeled CRF neurons in the paraventricular nucleus were also immunorea...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90073-l
更新日期：1992-09-01 00:00:00
abstract：:Subcortical vascular dementia (SVD) is a small vessel disease with dementia that exhibits relatively uniform clinical and pathological features and constitutes approximately half of vascular dementia (VaD) cases. This subtype is further classified into Binswanger's disease and multiple lacunar infarctions. The former ...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2011.07.1820
更新日期：2011-11-01 00:00:00
abstract：:We previously showed that our neural stem sphere (NSS) method promotes the neuronal differentiation of mouse, monkey and human embryonic stem (ES) cells. Here we analyzed changes in expression of marker genes and proteins during neuronal differentiation. When cultured in astrocyte-conditioned medium (ACM) under free-f...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.12.014
更新日期：2011-04-01 00:00:00
abstract：:In an attempt to test the possibility that sino-aortic baroreceptors may mediate the previously reported stress response in hypothalamic magnocellular neurosecretory cell activity in rats, effects of deafferentation of sino-aortic baroreceptors on plasma levels of vasopressin and oxytocin after fear-related emotional ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90059-l
更新日期：1992-04-01 00:00:00
abstract：:Recent studies have shown that certain aromatic aldehydes are ligands for olfactory receptors expressed in mammalian sperm cells and induce sperm chemotaxis. Using a conditioning paradigm, the olfactory sensitivity of five CD-1 mice for seven aromatic aldehydes was investigated. With all seven stimuli, the mice discri...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.08.009
更新日期：2011-12-01 00:00:00
abstract：:In our previous study using the whole-cell patch clamp technique combined with reverse transcription-polymerase chain reaction analysis in rat brainstem slices, we demonstrated that the classification of neurons in the medial vestibular nucleus (MVN) based on three membrane properties detected as voltage response prop...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.06.1479
更新日期：2007-10-01 00:00:00
abstract：:Recent rapid progress in genome analysis and large-scale consortia has made it possible to discover variants with a variety of allele frequencies and effect sizes associated with psychiatric disorders. Among psychiatric disorder-susceptibility variants, rare variants with large effect sizes detected by sequencing anal...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2020.11.008
更新日期：2020-12-11 00:00:00
