Inhibition of TGF-beta1 promotes functional recovery after spinal cord injury.

abstract：:Although the rat has been the predominant rodent used to investigate the pathophysiology and treatment of experimental spinal cord injury (SCI), the increasing availability of transgenic animals has led to greater use of mouse models. However, behavioral assessment after SCI in mice has been less extensively investiga...

journal_title：Neuroscience research

authors： Pajoohesh-Ganji A,Byrnes KR,Fatemi G,Faden AI

更新日期：2010-06-01 00:00:00

abstract：:Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are g...

journal_title：Neuroscience research

authors： Yamaguchi Y

更新日期：2018-04-01 00:00:00

abstract：:Developmental refinement of neuronal connectivity is crucial for proper brain function. In the early phase of development, input fibers arrive at their target areas guided by specific molecular cues and form abundant immature synapses. Then, functionally important synapses are preserved and strengthened by neural acti...

journal_title：Neuroscience research

authors： Narushima M

更新日期：2018-04-01 00:00:00

abstract：:Pseudorabies virus (PrV) as a neuronal tracer was microinjected into the concave surface of the puppy's left pinna to establish the morphological basis of somato-visceral linkage. The virus infected neurons were detected by FITC conjugated with polyclonal swine anti-PrV serum. Labelled neurons were localized in: (1) t...

journal_title：Neuroscience research

authors： Chien CH,Shieh JY,Liao MH,Ling EA,Wen CY

更新日期：1998-02-01 00:00:00

abstract：:Neuropsin is a serine protease cloned from the mouse hippocampus. Since neuropsin is a secreted protein which effectively cleaves fibronectin, it may affect cell adhesion or cell migration by modulating the content and/or chemical characteriscs of fibronectin in extracellular matrix (ECM). In adhesion assays, alpha5B2...

journal_title：Neuroscience research

authors： Tani N,Matsumoto K,Ota I,Yoshida S,Takada Y,Shiosaka S,Matsuura N

更新日期：2001-02-01 00:00:00

abstract：:To evaluate recovery function of and effects of hyperventilation (HV) on high-frequency oscillations (HFOs) of median nerve somatosensory evoked potential (SEP), we recorded SEPs in 8 Parkinson's disease (PD) patients with enlarged HFOs, 4 myoclonus epilepsy (ME) patients and 10 healthy volunteers (N). SEP was recorde...

journal_title：Neuroscience research

authors： Mochizuki H,Machii K,Terao Y,Furubayashi T,Hanajima R,Enomoto H,Uesugi H,Shiio Y,Kamakura K,Kanazawa I,Ugawa Y

更新日期：2003-08-01 00:00:00

abstract：:Close relationships between the nervous system and immune systems at molecular levels have now become evident. Receptors for CDF/LIF and CNTF, i.e., factors which play important roles in the nervous system, share a close structural similarity to those for IL-6, which is a molecule acting in the immune system. Receptor...

journal_title：Neuroscience research

authors： Yamamori T,Sarai A

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD). METHOD:EEGs were recorded from 22 AD patients and 23 age-matched healthy...

journal_title：Neuroscience research

authors： Park YM,Che HJ,Im CH,Jung HT,Bae SM,Lee SH

更新日期：2008-10-01 00:00:00

abstract：:In previous studies we provided evidence for changes in prolactin (PRL) receptor levels in the male rat brain after continuously infusing morphine using subcutaneously implanted miniosmotic pumps. In this work we have studied the binding of PRL in the male rat brain following morphine administration by both subcutaneo...

journal_title：Neuroscience research

authors： Lai Z,Zhai Q,Liu Z,Roos P,Nyberg F

更新日期：1995-10-01 00:00:00

abstract：:The contribution of nociceptive Aδ-fibres and C-fibres of the central pad of the foot to nociceptive spinal flexor reflex pathways (FRA-type) and to nociceptive excitatory reflex pathways to foot extensors (non-FRA type) was investigated in high spinal cats. Persisting effects after complete blocking of A-fibres by te...

journal_title：Neuroscience research

authors： Schomburg ED,Dibaj P,Steffens H

更新日期：2011-03-01 00:00:00

abstract：:We newly developed an infrared video-oculographic system for on-line tracking of the eye position in awake and head-fixed mice, with high temporal resolution (240 Hz). The system consists of a commercially available high-speed CCD camera and an image processing software written in LabVIEW run on IBM-PC with a plug-in ...

journal_title：Neuroscience research

authors： Sakatani T,Isa T

更新日期：2004-05-01 00:00:00

abstract：:We have previously shown that endothelin-B receptor stimulation increases neural progenitor proliferation, partly in G(i) and extracellular matrix molecule-dependent manner. In the present study, we investigated whether G(q/11) is also involved in this response and how G(i) and G(q/11) might regulate the extracellular...

journal_title：Neuroscience research

authors： Morishita R,Ueda H,Ito H,Takasaki J,Nagata K,Asano T

更新日期：2007-10-01 00:00:00

abstract：:DJ-1 is a multifunctional protein linked to recessively inherited Parkinson's disease (PD) due to loss of function mutations. Among its activities is anti-oxidant property leading to cytoprotection under oxidative stress conditions. A key effector of oxidant-induced cell death is the MAP3 kinase apoptosis signal-regul...

journal_title：Neuroscience research

authors： Im JY,Lee KW,Junn E,Mouradian MM

更新日期：2010-07-01 00:00:00

abstract：:Glutamate is the principal excitatory neurotransmitter in the mammalian central nervous system (CNS). Glutamate is first synthesized in the cytoplasm of presynaptic terminals before being loaded into synaptic vesicles, which fuse with the plasma membrane, releasing their contents, in response to neuronal activity. The...

journal_title：Neuroscience research

authors： Takamori S

更新日期：2006-08-01 00:00:00

abstract：:The cyclic nucleotides perform a variety of roles in the formation and remodeling of the neuronal interaction. The membrane microdomain called "raft" has been paid much attention, for this domain contains many signal-transducing molecules including trimeric G proteins and cytoskeletal proteins. The raft domain is reco...

journal_title：Neuroscience research

authors： Noyama K,Maekawa S

更新日期：2003-02-01 00:00:00

abstract：:Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...

journal_title：Neuroscience research

authors： Okada M,Sakaguchi T,Kawasaki K

更新日期：1995-07-01 00:00:00

abstract：:The distribution of neurofilament proteins and peripherin in the pituitary gland of the rat was studied with a panel of monoclonal and polyclonal antibodies recognizing different neurofilament subunits. In the posterior lobe, a dense plexus of neurofilament- and peripherin-immunoreactive fibers was seen. In the interm...

journal_title：Neuroscience research

authors： Bäck N,Tyynelä M,Portier MM,Virtanen I,Soinila S

更新日期：1995-06-01 00:00:00

abstract：:The magnitude of long-term potentiation (LTP) was re-examined for monosynaptic transmission between mossy fibers and CA3 neurons in thin sections of the hippocampus of the guinea pig. Although an initial negative deflection in the field potential showed apparent short-term potentiation, this deflection was concluded t...

journal_title：Neuroscience research

authors： Higashima M,Yamamoto C

更新日期：1986-09-01 00:00:00

abstract：:Resveratrol shows ability to eliminate prion replication, but the exact mechanism for prion eradication was not clear yet. Our previous studies demonstrate a downregulation of brain-derived nerve growth factor (BDNF) during prion infection, meanwhile recovery of cerebral nerve growth factor (NGF) level by resveratrol ...

journal_title：Neuroscience research

authors： Hu C,Chen C,Chen J,Xiao K,Wang J,Shi Q,Ma Y,Gao LP,Wu YZ,Liu L,Xia Y,Yan P,Maimaitiming A,Zhou DH,Zhang LN,Chen ZB,Dong XP

更新日期：2021-01-01 00:00:00

abstract：:To elucidate biophysical mechanisms underlying the Zn2+ block on the low-threshold T-type Ca2+ current (I(T)), we examined the Zn(2+)-induced alterations of gating properties of I(T) of a rat thalamic relay neuron and of alpha1G channels expressed in HEK-293 cells, using a whole-cell voltage clamp technique. The effec...

journal_title：Neuroscience research

authors： Noh J,Kim MK,Chung JM

更新日期：2010-04-01 00:00:00

abstract：:Sensitivities of neurons to acetylcholine (ACh), noradrenaline (NA) and dopamine (DA) were investigated at different depths of the dorsolateral prefrontal cortex (PFC) in awake or halothane-anesthetized macaque monkeys, using microiontophoretic techniques with multi-barreled electrodes. The laminar locations of tested...

journal_title：Neuroscience research

authors： Sawaguchi T,Matsumura M

更新日期：1985-04-01 00:00:00

abstract：:Electromyograms were recorded from the intralaryngeal muscles (the posterior cricoarytenoid (PCA) and thyroarytenoid (TA) muscles) and the ventilatory muscles (the diaphragm (DA) and abdominal (RA) muscle) during electrically induced vocalization in precollicular postmammillary decerebrate cats. Electrical stimulation...

journal_title：Neuroscience research

authors： Yamanaka Y,Sakamoto T,Wada K,Nakajima Y

更新日期：1993-06-01 00:00:00

abstract：:We developed a new method to visualize the myeloarchitecture in fresh slices, and investigated the properties of the functional neural connections around the boundary between the primary auditory cortex (area 41) and area 18a in rat cerebral slices. A fresh slice illuminated by near-vertical light was observed with a ...

journal_title：Neuroscience research

authors： Hishida R,Hoshino K,Kudoh M,Norita M,Shibuki K

更新日期：2003-06-01 00:00:00

abstract：:After horseradish peroxidase was applied to the main trunk of the mouse vagal nerve, anterogradely labeled cells in the vagal ganglia and fibers in the solitary complex, and retrogradely labeled cells in the dorsal motor nucleus and the ambiguous nucleus were observed. Most of the cells in the nodose ganglion were lab...

journal_title：Neuroscience research

authors： Funakoshi K,Kusakabe T,Kadota T,Goris RC,Kishida R

更新日期：1989-12-01 00:00:00

abstract：:It is still incompletely known how NMDA receptors (NMDA-R) regulate bidirectional synaptic plasticity. We examined this issue by an experimental protocol in which paired pulse stimulation (PPS) with 50ms interstimulus interval and basal frequency of 0.1Hz was applied to CA1 area of rat hippocampal slices during low Mg...

journal_title：Neuroscience research

authors： Huang FS,Abbas AK,Li R,Afanasenkau D,Wigström H

更新日期：2010-06-01 00:00:00

abstract：:In identified B6 neurons of Aplysia buccal ganglia under voltage-clamp, application of quisqualic acid (QA) induces a unique slow K(+)-current response independent of G-protein. The response was augmented by raising the temperature in a similar fashion to the Phe-Met-Arg-Phe-NH(2)-induced K(+)-current response mediate...

journal_title：Neuroscience research

authors： Kimura S,Kawasaki S,Watanabe S,Fujita R,Sasaki K

更新日期：2008-01-01 00:00:00

abstract：:It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...

journal_title：Neuroscience research

authors： Kamiji NL,Yamamoto K,Hirasawa H,Yamada M,Usui S,Kurokawa M

更新日期：2012-04-01 00:00:00

abstract：:In acute decerebrate cats, medial pontine reticular formation (mPRF) and the mesencephalic locomotor region (MLR) were stimulated and their stimulus effects upon 250 medullary reticulospinal neurons (RSNs) were studied. One hundred and twenty-six RSNs were mono- and disynaptically activated. From the response patterns...

journal_title：Neuroscience research

authors： Iwakiri H,Oka T,Takakusaki K,Mori S

更新日期：1995-08-01 00:00:00

abstract：:Medial preoptic area (MPA), supraoptic nucleus (SON), magnocellular (MaPVN) and parvocellular (PaPVN) paraventricular hypothalamic nuclei, and mesencephalic lateral tegmentum (MLT) are involved in maternal behavior, parturition and lactation. This study investigated the FosB and Fos immunoreactivity in these regions o...

journal_title：Neuroscience research

authors： Lin SH,Miyata S,Weng W,Matsunaga W,Ichikawa J,Furuya K,Nakashima T,Kiyohara T

更新日期：1998-12-01 00:00:00

abstract：:Following neonatal hypoxia-ischemia (HI) serotonin (5-hydroxytryptamine, 5-HT) levels are decreased in the brain. The regulation of brain 5-HT is dependent on the serotonin transporter (SERT) localised at the neuronal pre-synaptic cell membrane. However SERT can also traffic away from the cell membrane into the cytoso...

journal_title：Neuroscience research

authors： Wixey JA,Reinebrant HE,Buller KM

更新日期：2012-07-01 00:00:00