Arginine vasopressin signaling in the suprachiasmatic nucleus on the resilience of circadian clock to jet lag.

Abstract:

:Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are generated by a timing system comprised of a master pacemaker located in the suprachiasmatic nucleus (SCN) of the anterior hypothalamus, which orchestrates the clocks in the peripheral tissues. Jet lag, caused by an abrupt change of environmental light-dark cycles, induces a temporal misalignment of the output signal from SCN. We revealed that arginine vasopressin/V1 receptor signaling in the SCN plays a critical role in the resilience of the circadian clock to jet lag. I here discuss a model of SCN neuronal system under a jet lag condition.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Yamaguchi Y

doi

10.1016/j.neures.2017.10.007

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

57-61

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(17)30408-X

journal_volume

129

pub_type

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