Abstract：
:Damage to the central nervous system (CNS) leads to the disruption of the axonal network and causes neurological dysfunction. Recovery of neurological functions requires restoration of the axonal network; however, injured axons in the adult mammalian CNS rarely regenerate after injury. Failure of the injured axon to regenerate is attributed at least partly to the inhibitory molecules of the CNS: several proteins have been identified in the CNS that inhibit axonal regeneration. In addition, the molecular mechanisms underlying the manner via which these inhibitors prevent axonal regeneration have been clarified. The neutralization of nonpermissive substrate properties of the CNS has been shown to promote axonal regeneration in an animal model of CNS injury. Drugs that promote axonal regeneration, some of which have undergone clinical trials, have been developed by pharmaceutical companies. However, spontaneous functional recovery occurs sometimes after CNS injury. This review will describe the new concept of the molecular mechanism of restoration of the neuronal network, with a special focus on our recent reports.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Muramatsu R,Yamashita Tdoi
10.1016/j.neures.2013.07.002subject
Has Abstractpub_date
2014-01-01 00:00:00pages
45-9eissn
0168-0102issn
1872-8111pii
S0168-0102(13)00179-Xjournal_volume
78pub_type
杂志文章,评审abstract：:Mature rat spinal cord cDNA libraries constructed in lambda gt10 and lambda ZAPII were screened with an oligonucleotide probe (39 mer), and 4 clones that possess DNA-inserts encoding a glycine receptor subunit were obtained. The cloned cDNAs were used to reconstruct the nucleotide sequence of the full-length open read...
journal_title：Neuroscience research
pub_type： 杂志文章
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abstract：:In acute decerebrate cats, medial pontine reticular formation (mPRF) and the mesencephalic locomotor region (MLR) were stimulated and their stimulus effects upon 250 medullary reticulospinal neurons (RSNs) were studied. One hundred and twenty-six RSNs were mono- and disynaptically activated. From the response patterns...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90004-i
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.09.007
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.03.006
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)00864-c
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(85)90021-5
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.01.011
更新日期：2007-05-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90023-0
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abstract：:The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.06.013
更新日期：2006-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2003.08.005
更新日期：2003-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.01.011
更新日期：2020-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00064-4
更新日期：1999-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.11.002
更新日期：2010-02-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.09.001
更新日期：2008-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00075-3
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2013-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2015-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90021-3
更新日期：1994-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：1992-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.03.009
更新日期：2004-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(85)90016-1
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.01.007
更新日期：2008-05-01 00:00:00
abstract：:The interaction of neurotransmitter receptors with the underlying cytoskeleton via subsynaptic proteins is an important mechanism for the targeting of the receptors to synapses in the central nervous system. We show that delta glutamate receptors (delta receptors), expressed predominantly in the dendritic spines of ce...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00061-9
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abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...
journal_title：Neuroscience research
pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
abstract：:Pathological gambling (PG) is a non-substance based addiction that shares many behavioral and neural features with substance based addictions. However, in PG behavioral and neural changes are unlikely to be confounded by effects of acute or chronic drug exposure. Changes in reward based decision-making in particular i...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
abstract：:The present study was performed to determine whether the voltage gated Cl- channel (CLC) expression is altered in the hippocampus of seizure sensitive (SS) gerbils, and to identify the strong fast paired-pulse inhibition in the dentate gyrus of SS gerbils is associated with altered CLC expression. In the hippocampal p...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.09.010
更新日期：2005-01-01 00:00:00
abstract：:The Madagascan lesser hedgehog tenrec was investigated to get insight into the areal evolution of the hippocampal formation in mammals with poorly differentiated brains. The hippocampal subdivisions were analyzed using cyto- and chemoarchitectural criteria; long associational and commissural connections were demonstra...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00288-7
更新日期：2001-11-01 00:00:00
