Abstract：
:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, revealed a taurine concentration-dependent biphasic-modulation of the receptor: at 0.3-30 microM taurine potentiated the GABA-currents, whereas at 0.3-30 mM the GABA-currents were reduced. In contrast glycine potentiated the GABA-currents at all concentrations tested. TPMPA, a GABA(C) specific receptor antagonist, also blocked effectively and reversibly the taurine and glycine currents. Finally, lanthanum and zinc modulated the currents generated by the three amino acids. Taurine is abundant in the retina and our observations suggest that taurine may play an important role modulating the retinal GABAergic transmission.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Ochoa-de la Paz LD,Martínez-Dávila IA,Miledi R,Martínez-Torres Adoi
10.1016/j.neures.2008.03.009subject
Has Abstractpub_date
2008-07-01 00:00:00pages
302-8issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(08)00086-2journal_volume
61pub_type
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pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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更新日期：2010-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:It has been indicated that Pyk2/Src signaling pathway is involved in modulation of N-methyl-D-aspartate-type (NMDA) glutamate receptor activity. Lithium protects against glutamate-induced excitotoxicity in cultured neurons and in animal models of diseases. The neuroprotection against excitotoxicity afforded by lithium...
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更新日期：2004-08-01 00:00:00
