Abstract：
:The hypothalamic paraventricular nuclei (PVN) inhibits spinal nociception. Furthermore, projections from the PVN to other structures related to pain modulation exist, but a functional interaction has not yet been fully demonstrated. As an initial approach, we show here that PVN electric stimulation with the same parameters used to induce analgesia in rats enhances c-Fos expression not only in the dorsal horn of the spinal cord but also in the nucleus raphe magnus, locus coeruleus and the periaqueductal gray area. These results suggest that a functional interaction between these structures could occur, possibly to assure a mechanism of endogenous analgesia.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Condés-Lara M,Martínez-Lorenzana G,Rubio-Beltrán E,Rodríguez-Jiménez J,Rojas-Piloni G,González-Hernández Adoi
10.1016/j.neures.2015.04.004subject
Has Abstractpub_date
2015-09-01 00:00:00pages
59-63eissn
0168-0102issn
1872-8111pii
S0168-0102(15)00131-5journal_volume
98pub_type
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