Abstract：
:The change in [Ca2+]i, in a retinal rod outer segment to flash and step stimuli was simulated. The present model included inward and outward calcium fluxes through cation channels and an Na-Ca-K exchanger, respectively, calcium buffers, and diffusion through the interdiskal space of cytoplasm and incisures. Under control conditions (with the diffusion constant for calcium (DCa) of 10(-10) m2/s and the total concentration ([B]t) of 240 microM) the decrease in [Ca2+]i to flash stimuli was found to be localized around the edge of a disk irrespective of the presence or absence of incisures. Homogeneous but limited degree of decrease in [Ca2+]i was seen under a larger DCa of 10(-9) m2/s with no incisure. For the step illumination by which all the cation channels on a plasma membrane were closed, the decrease in [Ca2+]i around the edge of a disk was quick, while that at the center of an interdiskal space was slow (50% of the resting level at 5 s after the onset of the step illumination). These results indicate that the calcium feedback on guanylate cyclase and possibly on S-modulin in response to flash stimuli proceeds only around the edge of disk membranes or on the plasma membrane. This implicates localized mechanisms for the signal transduction and early phase of adaptation within rod outer segments.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Ichikawa Kdoi
10.1016/0168-0102(96)01035-8subject
Has Abstractpub_date
1996-06-01 00:00:00pages
137-44issue
2eissn
0168-0102issn
1872-8111pii
0168-0102(96)01035-8journal_volume
25pub_type
杂志文章abstract：:Saccadic eye movement is a rapid shift of eye position to capture an object in the environment. In this study, we will describe the fundamental properties of spontaneously evoked saccade-like rapid eye movement (SLREM) in mice in order to establish the mouse experimental model for studying saccades. Spontaneous SLREM ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.04.003
更新日期：2007-07-01 00:00:00
abstract：:The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles. The experiments were performed on 7 ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)00864-c
更新日期：1995-02-01 00:00:00
abstract：:We excised the dorsal part of the optic vesicle of chick embryos at stages 13-14 (embryonic day 2). The remainder of the optic vesicle reoganized and developed a small eye. This study was undertaken to determine how locus specificity is kept within the reorganized retina. The projection pattern from the reorganized ey...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90022-5
更新日期：1992-10-01 00:00:00
abstract：:In lightly alpha-chloralose anaesthetized cats, activity was recorded simultaneously from 2-4 primary muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles. Increased tension in medial or lateral collateral ligament was found to evoke changes in the responses of the primary spi...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90066-8
更新日期：1991-06-01 00:00:00
abstract：:Dynamic properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic response (OKR) were studied in mice. The VOR was examined in the dark (VORD), in the light (VORL) and in the condition in which most of the visual field moves synchronously with the head motion (VORF). A mouse and/or a surrounding screen wi...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00228-5
更新日期：2001-03-01 00:00:00
abstract：:Light-induced changes in the input resistance (Rin) of external, luminosity (i.e. H1) type horizontal cell (HC) perikarya were studied by the bridge-balance method in light-adapted and dark-adapted retinae of carp. Changes in input resistance (delta Rin) induced by short-(460 nm) and long-wavelength (674 nm) flashes, ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(96)01133-9
更新日期：1997-01-01 00:00:00
abstract：:To elucidate the interaction between nitric oxide (NO) and substance P (SP) in neurogenic inflammatory responses, we measured the change in the degree of Evans blue leakage and NO levels in perfusate from the subcutaneous space in the rat instep following noxious heat stimulation (47 degrees C for 30 min). Furthermore...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00107-8
更新日期：2000-01-01 00:00:00
abstract：:We recorded 101 neurons in the nucleus of the optic tract (NOT) of 3 rhesus monkeys. The neurons were tested in a variety of oculomotor paradigms. This report focusses on the modulation of NOT neuronal activity during smooth pursuit eye movements. A small horizontally moving spot (less than 1 degrees) elicited a direc...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90103-6
更新日期：1991-10-01 00:00:00
abstract：:Hippocampal neurogenesis is influenced by many factors. In this study, we examined the effect of tactile stimulation (tickling), which induced positive emotion, on neurogenesis in the dentate gyrus (DG) of the hippocampus. Four week-old rats were tickled for 5 min/day on 5 consecutive days and received 5-bromo-2'-deox...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.09.001
更新日期：2010-12-01 00:00:00
abstract：:The lateral olfactory tract (LOT) is a central olfactory pathway, and efferent projections from the olfactory bulb are conveyed to the olfactory-related cortical structures via the LOT. The purpose of the present study is to determine the exact site of the LOT causing functional impairment in animals. After ablation o...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.02.006
更新日期：2012-05-01 00:00:00
abstract：:Event-related potentials (ERPs) during an auditory discrimination task were recorded both on the surface and at a depth of the auditory cortex in rats. Ten-kilohertz rare and 5-kHz frequent tones were used with the probabilities of 0.2 and 0.8. Lever pressing within 2 s, following the onset of the rare tone, was rewar...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90073-6
更新日期：1994-11-01 00:00:00
abstract：:The influence of the phosphorylation dephosphorylation states on the gamma-aminobutyric acid (GABA) transporter activity of synaptic plasma membranes (SPM) was studied by using either specific phosphatase inhibitors or activators. Calyculin A and okadaic acid (phosphatase 1 and phosphatase 2A inhibitors) inhibited the...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00107-2
更新日期：1999-01-01 00:00:00
abstract：:The contribution of intrinsic balance control factors to fall mechanisms has received little investigation in studies on occupational accidents. The aim of this study was to assess whether postural regulation in falling workers might have specificities in terms of sensorimotor strategies and neuromuscular responses to...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.11.001
更新日期：2004-03-01 00:00:00
abstract：:The peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPARα on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10μg/1μL; PPARα agonist) enhanced wakefu...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.09.005
更新日期：2016-04-01 00:00:00
abstract：:The cranial nerves and the brain fiber systems of the medaka (Oryzias latipes) fry are revealed by a whole-mount staining method. Newly hatched fry of an albino strain of the medaka were fixed, partially digested with trypsin, treated in 1% Triton X-100, and finally immunohistochemically stained using anti-neurofilame...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90079-5
更新日期：1994-06-01 00:00:00
abstract：:The effect of apamin, a bee venom toxin, on the action potential and the spike after hyperpolarization was studied in bullfrog sympathetic ganglion cells. Apamin reduced the duration of the afterhyperpolarization but did not affect the maximum rates of rise and fall of Na+- and Ca2+-dependent action potentials. In the...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(85)90029-x
更新日期：1985-12-01 00:00:00
abstract：:Repetitive transcranial magnetic stimulation (rTMS), which could improve learning and memory, is widely used in psychiatry and neurology as a therapeutic approach. There are few studies reporting effective countermeasures to cognition decline in astronauts during space flight. Accordingly, we examined whether rTMS was...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.04.002
更新日期：2020-04-01 00:00:00
abstract：:Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In volta...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(96)01071-1
更新日期：1996-09-01 00:00:00
abstract：:The current study evidenced hypothesis that mitochondrial dysfunction-oxidative stress-dependent apoptotic pathways play a critical role in degeneration of dopaminergic neurons in Parkinson's disease. Model of rotenone-induced parkinsonism in rats produced decrease in striatal complex I activity and reduced glutathion...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.08.008
更新日期：2011-12-01 00:00:00
abstract：:ATP-sensitive K(+) (K(ATP)) channel subunits SUR2A and SUR2B in the rat brain were investigated by RT-PCR assay, western blot analysis, in situ hybridization histochemistry, and immunohistochemical staining. The results show that the mRNA and protein of SUR2A and SUR2B are expressed in whole rat brain extracts and sel...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.08.005
更新日期：2012-10-01 00:00:00
abstract：:It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.07.002
更新日期：2012-09-01 00:00:00
abstract：:Functional near-infrared spectroscopy (fNIRS) is a method of monitoring brain oxygenation. This technique investigates hemodynamic changes in the cerebral cortex. fNIRS is widely used in clinical and scientific research. In this review, we focus on the applications of fNIRS on neonates. Here, applications form two dis...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2020.11.003
更新日期：2020-12-30 00:00:00
abstract：:Some evidence suggests that sleep deprivation might impair synaptic plasticity and produce oxidative stress in the hippocampus. However it is not clear whether impairment of long-term potentiation depends on the oxidative stress evoked by sleep deprivation protocol. In this study we aimed to investigate the effects of...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.01.008
更新日期：2011-05-01 00:00:00
abstract：:We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.03.016
更新日期：2009-07-01 00:00:00
abstract：:Human's sophisticated motor learning system paradoxically interferes with motor performance when visual information is mirror-reversed (MR), because normal movement error correction further aggravates the error. This error-increasing mechanism makes performing even a simple reaching task difficult, but is overcome by ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.12.010
更新日期：2015-05-01 00:00:00
abstract：:By combining biochemical, molecular and immunohistochemical approaches, we have investigated the presence of metabotropic glutamate receptors (mGluRs) belonging to the subtype 5 in rat and human spinal cords and the developmental changes in their expression. A polyclonal antibody raised against the carboxy-terminal po...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)01175-9
更新日期：1997-05-01 00:00:00
abstract：:Experiments were performed to study the projection of the group y of the vestibular nuclei and the dentate and fastigial nuclei of the cerebellum to the interstitial nucleus of Cajal (INC) in cats by using retrograde axonal transport of horseradish peroxidase (HRP) and electrophysiological methods; and to study the ve...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(86)90021-0
更新日期：1986-05-01 00:00:00
abstract：:To evaluate recovery function of and effects of hyperventilation (HV) on high-frequency oscillations (HFOs) of median nerve somatosensory evoked potential (SEP), we recorded SEPs in 8 Parkinson's disease (PD) patients with enlarged HFOs, 4 myoclonus epilepsy (ME) patients and 10 healthy volunteers (N). SEP was recorde...
journal_title：Neuroscience research
pub_type： 临床试验,杂志文章
doi：10.1016/s0168-0102(03)00129-9
更新日期：2003-08-01 00:00:00
abstract：:γ-Aminobutyric acid (GABA) generally induces hyperpolarization and inhibition in the adult brain, but causes depolarization (and can be excitatory) in the immature brain. Depolarizing GABA actions are necessary for neurogenesis, differentiation, migration, and synaptogenesis. Additionally, the conversion of GABA respo...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2020.02.010
更新日期：2020-07-01 00:00:00
abstract：:The subiculum is one of output structures of the hippocampal formation and plays a pivotal role in learning and memory. Because its morphological features are less investigated than those of the hippocampus proper, we explored the internal structure of the rat subiculum using immunohistochemistry. The septal subiculum...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.02.001
更新日期：2020-01-01 00:00:00
