Abstract：
:A mixture of peptidase inhibitors increased the magnitude of the saphenous nerve-evoked slow depolarization of a lumbar ventral root and prolonged the similarly evoked inhibition of monosynaptic reflex (MSR) in the isolated spinal cord of the newborn rat in the presence of naloxone. The saphenous nerve-evoked MSR inhibition was curtailed by a tachykinin antagonist, GR71251, and after the treatment with GR71251, the peptidase inhibitor mixture no more prolonged the MSR inhibition. The present results suggest that enzymatic degradation plays a role in the termination of action of tachykinins released from primary afferents in the newborn rat spinal cord. The results provide a further support for the notion that tachykinins serve as neurotransmitters in the spinal cord of the newborn rat.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Yanagisawa M,Yoshioka K,Kurihara T,Saito K,Seno N,Suzuki H,Hosoki R,Otsuka Mdoi
10.1016/0168-0102(92)90050-msubject
Has Abstractpub_date
1992-12-01 00:00:00pages
289-92issue
4eissn
0168-0102issn
1872-8111pii
0168-0102(92)90050-Mjournal_volume
15pub_type
杂志文章abstract：:Catecholamine neurotransmitters--dopamine, noradrenaline (norepinephrine), adrenaline (epinephrine)--are synthesized in catecholaminergic neurons from tyrosine, via dopa, dopamine and noradrenaline, to adrenaline. Four enzymes are involved in the biosynthesis of adrenaline: (1) tyrosine 3-mono-oxygenase (tyrosine hydr...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(91)90001-f
更新日期：1991-10-01 00:00:00
abstract：UNLABELLED:Angiotensin II receptors (Ang II), classified into AT1 and AT2 subtypes, are located in different regions of the central nervous system, including the cardiovascular control centers in the medulla oblongata. We previously reported the role of Ang II AT1 receptors within the medulla on cardiovascular response...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.04.008
更新日期：2009-08-01 00:00:00
abstract：:To gain insight into the basic neurobiological processes regulated by lithium--an effective drug for bipolar disorder--we used Affymetrix Genome Arrays to examine lithium-induced changes in genome-wide gene expression profiles of head mRNA from the genetic model organism Drosophila melanogaster. First, to identify the...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.04.015
更新日期：2009-08-01 00:00:00
abstract：:Metabolism of amyloid-beta peptide (Abeta) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Since neprilysin is the only rate-limiting catabolic peptidase proven by reverse genetics to participate in Abeta metabolism in vivo, we performed detailed immunohistochemical analysis of nepri...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00015-9
更新日期：2002-05-01 00:00:00
abstract：:Some evidence suggests that sleep deprivation might impair synaptic plasticity and produce oxidative stress in the hippocampus. However it is not clear whether impairment of long-term potentiation depends on the oxidative stress evoked by sleep deprivation protocol. In this study we aimed to investigate the effects of...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.01.008
更新日期：2011-05-01 00:00:00
abstract：:Resveratrol shows ability to eliminate prion replication, but the exact mechanism for prion eradication was not clear yet. Our previous studies demonstrate a downregulation of brain-derived nerve growth factor (BDNF) during prion infection, meanwhile recovery of cerebral nerve growth factor (NGF) level by resveratrol ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.12.019
更新日期：2021-01-01 00:00:00
abstract：:During development, neurons migrate from their origin to their final destinations where they form neuronal architectures such as layers and nuclei. While the mechanisms for the formation of laminated structures have been studied extensively, little is known about nucleogenesis. Previously, we analyzed nucleogenesis in...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.01.007
更新日期：2009-05-01 00:00:00
abstract：:The 14-3-3 protein family consists of evolutionarily conserved, acidic 30 kDa proteins composed of seven isoforms named beta, gamma, epsilon, zeta, eta, theta, and sigma in mammalian cells. The dimeric complex of 14-3-3 isoforms, acting as a molecular adaptor, plays a central role in regulation of neuronal function. S...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.03.007
更新日期：2008-07-01 00:00:00
abstract：:Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In ...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2013.03.014
更新日期：2013-08-01 00:00:00
abstract：:Glutamate is the principal excitatory neurotransmitter in the mammalian central nervous system (CNS). Glutamate is first synthesized in the cytoplasm of presynaptic terminals before being loaded into synaptic vesicles, which fuse with the plasma membrane, releasing their contents, in response to neuronal activity. The...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2006.04.016
更新日期：2006-08-01 00:00:00
abstract：:Electrical stimulation could enhance nerve regeneration and functional recovery. The objective of this study was to evaluate the regenerative effects of implanted electrodes with different contacts in resected sciatic nerve. Sciatic nerve resection and microsurgical repair models were established and randomly divided ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2018.08.007
更新日期：2019-08-01 00:00:00
abstract：:The distribution of ryanodine receptor-like immunoreactivity in the mouse central nervous system was studied using two antibodies raised against synthetic peptides. These peptides represented a region conserved between the cardiac and skeletal muscle forms and a region specific to the cardiac form. Western blotting an...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90026-9
更新日期：1992-10-01 00:00:00
abstract：:We previously showed that our neural stem sphere (NSS) method promotes the neuronal differentiation of mouse, monkey and human embryonic stem (ES) cells. Here we analyzed changes in expression of marker genes and proteins during neuronal differentiation. When cultured in astrocyte-conditioned medium (ACM) under free-f...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.12.014
更新日期：2011-04-01 00:00:00
abstract：:In the visual system, the afferent axons from the dorsal lateral geniculate nucleus (dLGN) to the primary visual cortex (V1) show significant activity-dependent plasticity in early postnatal life. To determine whether activity-dependent plasticity operates also in feedback projections from V1 to dLGN, we inactivated c...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.02.002
更新日期：2009-05-01 00:00:00
abstract：:We carried out voltage-sensitive dye imaging of the guinea pig auditory cortex to determine whether the ongoing and spontaneous activities of the cortex exhibit spatial coherence reflecting the tonotopic organization of the cortex. We used independent component analysis and a signal-plus-noise model to extract ongoing...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.01.007
更新日期：2008-05-01 00:00:00
abstract：:To investigate the effect of abrupt or non-abrupt isolation stress on the classical conditioned histamine release, socially isolated or paired guinea pigs underwent conditioning procedures in which ovalbumin (OA) as an unconditioned stimulus (US) and dimethylsulfide (sulfur smelling) as a conditioned stimulus (CS) wer...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00081-0
更新日期：2002-09-01 00:00:00
abstract：:In acute decerebrate cats, medial pontine reticular formation (mPRF) and the mesencephalic locomotor region (MLR) were stimulated and their stimulus effects upon 250 medullary reticulospinal neurons (RSNs) were studied. One hundred and twenty-six RSNs were mono- and disynaptically activated. From the response patterns...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:The A5 is an unique membrane protein that is expressed in the neurons of the visual system and general somatic sensory system of Xenopus laevis. We cultured retinal explants or trigeminal ganglion neurons on the monolayers of A5-expressing line cells obtained by transfection with the cDNA, and found that the A5-expres...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90092-5
更新日期：1993-07-01 00:00:00
abstract：:Stem cell-based therapy has recently offered a promising alternative for the remedy of neurodegenerative disorders like Huntington's disease (HD). Herein, we investigated the potential ameliorative effects of implantation of dental pulp stem cells (DPSCs) in 3-nitropropionic acid (3-NP) rat models of HD. In this regar...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2020.12.002
更新日期：2020-12-22 00:00:00
abstract：:Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzy...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00201-8
更新日期：2003-01-01 00:00:00
abstract：:Using median nerve injury and immunocytochemical methods, we examined the temporal changes in neuropeptide Y (NPY) expression in the cuneate nucleus (CN) in rats following median nerve transection. Under normal circumstances, neuropeptide Y-immunoreactive (NPY-IR) fibers was not detectable in the CN. A few NPY-IR fibe...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.12.003
更新日期：2004-04-01 00:00:00
abstract：:Type B neurons of the bullfrog sympathetic ganglia were examined to confirm the existence of axon collaterals and the distribution of synaptic contacts using the intracellular horseradish peroxidase (HRP) labeling method. The mean diameter of the perikarya was 60.8 (+/- 11.5 standard deviation; n = 36) X 43.8 (+/- 11....
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(89)90035-7
更新日期：1989-10-01 00:00:00
abstract：:We have generated a transgenic mouse model in which astrocytes express an enhanced green fluorescent protein (EGFP) under the control of the mouse glial fibrillary acidic protein (GFAP) promoter. EGFP, which is characteristically found throughout the cell, was expressed in these animals even in astrocytic fine process...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.08.008
更新日期：2003-12-01 00:00:00
abstract：:Methamphetamine (METH) is a psychostimulant that causes damage to dopamine (DA) axons and to non-monoaminergic neurons in the brain. The aim of the present study was to investigate short- and long-term effects of neurotoxic METH treatment on novelty-induced locomotor activity in mice. Male BALB/c mice, 12-14 weeks old...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.06.007
更新日期：2009-10-01 00:00:00
abstract：:Deficiency in n-3 fatty acids is known to disturb the release of dopaminergic neurotransmitters in rat brain. Since isomerization reduces the bioavailability of dietary fatty acids, the effect of the conversion of alpha-linolenic acid into trans alpha-linolenic acid on the dopaminergic neurotransmission was studied. R...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00249-3
更新日期：2003-04-01 00:00:00
abstract：:Effective connectivity analysis has been widely applied to noninvasive recordings such as functional magnetic resonance imaging and electroencephalograms (EEGs). Previous studies have aimed to extract the causal relations between brain regions, but the validity of the derived connectivity has not yet been fully determ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.09.003
更新日期：2020-07-01 00:00:00
abstract：:Acute exposure to kainic acid (KA) induces neurochemical changes in dopaminergic systems in the brain and the aim of the present study was to investigate the acute toxicity of KA upon dopamine D2 receptors. Adult rats were injected intraperitoneally with either saline or 16 mg/kg KA. Brains were removed after 4 h. Mem...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)00130-2
更新日期：1998-03-01 00:00:00
abstract：:In identified B6 neurons of Aplysia buccal ganglia under voltage-clamp, application of quisqualic acid (QA) induces a unique slow K(+)-current response independent of G-protein. The response was augmented by raising the temperature in a similar fashion to the Phe-Met-Arg-Phe-NH(2)-induced K(+)-current response mediate...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.09.007
更新日期：2008-01-01 00:00:00
abstract：:We studied the ascending and descending axonal trajectories of excitatory vestibular neurons related to the anterior semicircular canal, by means of local stimulation and spike-triggered signal averaging techniques in anesthetized cats. More than 200 vestibular neurons related to the ampullary nerve of the anterior se...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(84)90036-1
更新日期：1984-10-01 00:00:00
abstract：:To evaluate recovery function of and effects of hyperventilation (HV) on high-frequency oscillations (HFOs) of median nerve somatosensory evoked potential (SEP), we recorded SEPs in 8 Parkinson's disease (PD) patients with enlarged HFOs, 4 myoclonus epilepsy (ME) patients and 10 healthy volunteers (N). SEP was recorde...
journal_title：Neuroscience research
pub_type： 临床试验,杂志文章
doi：10.1016/s0168-0102(03)00129-9
更新日期：2003-08-01 00:00:00
