Abstract：
:Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a significant increase in Cry1 mRNA levels was caused by light pulse given at CT 16 but not at CT 4, but the expression of Cry2 was not significantly induced by light pulses given at either CT 4 or CT 16. These results suggest that Cry1 in the pineal gland is regulated by photic and circadian information but Cry2 is only regulated by circadian information.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Nakamura TJ,Shinohara K,Funabashi T,Mitsushima D,Kimura Fdoi
10.1016/s0168-0102(01)00255-3subject
Has Abstractpub_date
2001-09-01 00:00:00pages
25-32issue
1eissn
0168-0102issn
1872-8111pii
S0168010201002553journal_volume
41pub_type
杂志文章abstract：:Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are g...
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