Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity.

abstract：:Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the e...

journal_title：Neuroscience research

authors： Imamura N,Hida H,Aihara N,Ishida K,Kanda Y,Nishino H,Yamada K

更新日期：2003-07-01 00:00:00

abstract：:Hippocalcin is a recently identified Ca(2+)-binding protein with three EF-hand structures, dominantly expressed in the hippocampal pyramidal layer. The complete amino acid sequence of hippocalcin deduced from the cDNA is composed of 195 residues, has a calculated molecular mass of 22,574 daltons, and has a striking se...

journal_title：Neuroscience research

authors： Takamatsu K,Noguchi T

更新日期：1993-09-01 00:00:00

abstract：:The occurrence of multiple proteoglycan species is a characteristic of the brain. The structural features of individually characterized proteoglycans in the brain are first introduced in brief, then some examples are shown that suggest a relationship between multiple proteoglycans and the many distinct cell types and ...

journal_title：Neuroscience research

authors： Oohira A,Katoh-Semba R,Watanabe E,Matsui F

更新日期：1994-09-01 00:00:00

abstract：:Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarif...

journal_title：Neuroscience research

authors： Dai H,Kaneko K,Kato H,Fujii S,Jing Y,Xu A,Sakurai E,Kato M,Okamura N,Kuramasu A,Yanai K

更新日期：2007-02-01 00:00:00

abstract：:To investigate the effect of abrupt or non-abrupt isolation stress on the classical conditioned histamine release, socially isolated or paired guinea pigs underwent conditioning procedures in which ovalbumin (OA) as an unconditioned stimulus (US) and dimethylsulfide (sulfur smelling) as a conditioned stimulus (CS) wer...

journal_title：Neuroscience research

authors： Irie M,Nagata S,Endo Y

更新日期：2002-09-01 00:00:00

abstract：:Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In volta...

journal_title：Neuroscience research

authors： Koyano K,Funabiki K,Ohmori H

更新日期：1996-09-01 00:00:00

abstract：:Xenopus oocytes injected with messenger RNA extracted from rat brain are induced to acquire a variety of neurotransmitter receptors and voltage-operated membrane channels. Activation of the receptors to serotonin, acetylcholine (muscarinic) and glutamate elicits oscillatory membrane currents carried by chloride ions. ...

journal_title：Neuroscience research

authors： Parker I,Gundersen CB,Miledi R

更新日期：1985-08-01 00:00:00

abstract：:The rostro-caudal distribution of luteinizing hormone-releasing hormone (LHRH) in the hypothalamus of neonatally estrogenized (10 micrograms EB for 1-5 days), sterile female rats was compared with that of cycling rats at 50, 100 and 240 days of age. Serial slices of 400 microns in thickness in total were cut from a hy...

journal_title：Neuroscience research

authors： Hayashi S,Aihara M,Wakabayashi K

更新日期：1991-10-01 00:00:00

abstract：:Considerable evidence suggests that an N-methyl-D-aspartate (NMDA) receptor plays a crucial role in memory and cognitive function. To identify the role of this receptor in higher functions of the brain, we delivered antisense oligonucleotides against an NMDA-NR1 subunit (NR1) to the hippocampus in rats using the HVJ-l...

journal_title：Neuroscience research

authors： Inada K,Ishigooka J,Anzai T,Suzuki E,Miyaoka H,Saji M

更新日期：2003-04-01 00:00:00

abstract：:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, reveale...

journal_title：Neuroscience research

authors： Ochoa-de la Paz LD,Martínez-Dávila IA,Miledi R,Martínez-Torres A

更新日期：2008-07-01 00:00:00

abstract：:The structure of dendritic spines determines synaptic efficacy, a plastic process that mediates information processing in the vertebrate nervous system. Aberrant spine morphology, including alterations in shape, size, and number, are common in different brain diseases. Because of this, accurate and unbiased characteri...

journal_title：Neuroscience research

authors： Maiti P,Manna J,McDonald MP

更新日期：2015-07-01 00:00:00

abstract：:Disturbed circadian rhythmicity is associated with human diseases such as sleep and mood disorders. However, study of human endogenous circadian rhythm is laborious and time-consuming, which hampers the elucidation of diseases. It has been reported that peripheral tissues exhibit circadian rhythmicity as the suprachia...

journal_title：Neuroscience research

authors： Ebisawa T,Numazawa K,Shimada H,Izutsu H,Sasaki T,Kato N,Tokunaga K,Mori A,Honma K,Honma S,Shibata S

更新日期：2010-02-01 00:00:00

abstract：:Properties of the Ca2+ -activated K+ current (I[K(Ca)]) were investigated in bipolar cells isolated from the goldfish retina. Pharmacological experiments and single channel current recordings demonstrated that I[K(Ca)] represented currents through BK channels, which were confined mostly to the presynaptic terminal. Th...

journal_title：Neuroscience research

authors： Sakaba T,Ishikane H,Tachibana M

更新日期：1997-03-01 00:00:00

abstract：:alpha-Mannosidosis is a lysosomal storage disease resulting from a deficiency of the enzyme alpha-D-mannosidase. A major feature of alpha-mannosidosis is progressive neurological decline, for which there is no safe and effective treatment available. We have a guinea pig model of alpha-mannosidosis that models the huma...

journal_title：Neuroscience research

authors： Robinson AJ,Meedeniya AC,Hemsley KM,Auclair D,Crawley AC,Hopwood JJ

更新日期：2005-10-01 00:00:00

abstract：:Cerebral blood flow (CBF) is essential for neuronal metabolic functions. CBF is partly regulated by cholinergic projections from the nucleus basalis of Meynert (NBM) during cortical processing of sensory information. During pain-related processing, however, this mechanism may be altered by large fluctuations in system...

journal_title：Neuroscience research

authors： Paquette T,Tokunaga R,Touj S,Leblond H,Piché M

更新日期：2019-12-01 00:00:00

abstract：:The Approach-Avoidance Task (AAT) measures automatic approach-avoidance tendencies and their regulation: compatible reactions (approach positive, avoid negative) are faster than incompatible ones (approach negative, avoid positive). The present study assessed event-related potentials (ERPs) in 15 healthy persons for d...

journal_title：Neuroscience research

authors： Ernst LH,Ehlis AC,Dresler T,Tupak SV,Weidner A,Fallgatter AJ

更新日期：2013-03-01 00:00:00

abstract：:Environmental factors during perinatal period have various effects on behavior. The present study examined the effects of prenatal stress and neonatal handling on anxiety and spatial learning of offspring. Prenatal stress increased anxiety-related behavior of adult offspring, whereas neonatal handling had no effect. I...

journal_title：Neuroscience research

authors： Akatsu S,Ishikawa C,Takemura K,Ohtani A,Shiga T

更新日期：2015-12-01 00:00:00

abstract：:Changes in the features of responses of cortical taste neurons were studied in granular insular (GI) and dysgranular insular (DI) areas of urethane-anesthetized SD rats of four age groups (4-10, 14-20, 25-35 and > 90 days). Stimuli included four basic taste stimuli, 0.1 M NH4Cl, and the water extract of a food pellet,...

journal_title：Neuroscience research

authors： Ogawa H,Hasegawa K,Ohgushi M,Murayama N

更新日期：1994-06-01 00:00:00

abstract：:Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...

journal_title：Neuroscience research

authors： Bernstein DL,Nayak SU,Oliver CF,Rawls SM,Rom S

更新日期：2020-06-01 00:00:00

abstract：:Eye movements were induced by stimulating the ventral bank of the anterior ectosylvian sulcus (AES) of chloralose-anesthetized cats. Intracortical microstimulation of this cortex evoked centering movements of both eyes. The latency of eye movement was 45 ms (range 40-60 ms) and the intensity of stimulation was 33 micr...

journal_title：Neuroscience research

authors： Tamai Y,Miyashita E,Nakai M

更新日期：1989-11-01 00:00:00

abstract：:The disposition of the facial vibrissae of the mouse is represented as a matrix-like array of cell aggregates in rows and columns at every station of the whisker-to-barrel pathway. In order to evaluate the role of each station in this pathway, lesions were made in the facial vibrissae of the mystacial group on P0-P3, ...

journal_title：Neuroscience research

authors： Yamakado M

更新日期：1995-11-01 00:00:00

abstract：:In the vertebrate nervous system, glutamate (Glu) receptors are generally known to cause depolarizing responses. We report here a novel type of Glu response in Purkinje neurons of mouse cerebellar slices, namely glutamate-induced hyperpolarization (GH). This response is not due to activation of inhibitory interneurons...

journal_title：Neuroscience research

authors： Inoue T,Miyakawa H,Ito K,Mikoshiba K,Kato H

更新日期：1992-12-01 00:00:00

abstract：:The chemical properties of probes that improve amyloid detection by non-invasive (19)F magnetic resonance imaging (MRI) are of interest. We synthesized benzoxazole compounds with trifluoromethoxy groups, and found that these compounds displayed sharp (19)F nuclear magnetic resonance (NMR) signals in an assay buffer. H...

journal_title：Neuroscience research

authors： Amatsubo T,Morikawa S,Inubushi T,Urushitani M,Taguchi H,Shirai N,Hirao K,Kato M,Morino K,Kimura H,Nakano I,Yoshida C,Okada T,Sano M,Tooyama I

更新日期：2009-01-01 00:00:00

abstract：:The contribution of nociceptive Aδ-fibres and C-fibres of the central pad of the foot to nociceptive spinal flexor reflex pathways (FRA-type) and to nociceptive excitatory reflex pathways to foot extensors (non-FRA type) was investigated in high spinal cats. Persisting effects after complete blocking of A-fibres by te...

journal_title：Neuroscience research

authors： Schomburg ED,Dibaj P,Steffens H

更新日期：2011-03-01 00:00:00

abstract：:We suggest a time-varying partial correlation as a statistical measure of dynamic functional connectivity (dFC) in the human brain. Traditional statistical models often assume specific distributions on the measured data such as the Gaussian distribution, which prohibits their application to neuroimaging data analysis....

journal_title：Neuroscience research

authors： Lee N,Kim JM

更新日期：2020-07-03 00:00:00

abstract：:In 15 cats with implantations of crystalline HRP-WGA in the cerebellar nuclei and tetramethylbenzidine histochemistry, the pontine nuclei were carefully examined for presence of retrogradely labelled cells. Findings in the nucleus reticularis tegmenti pontis and the inferior olive, both known to project to the cerebel...

journal_title：Neuroscience research

authors： Brodal P,Dietrichs E,Walberg F

更新日期：1986-11-01 00:00:00

abstract：:Many forms of psychopathology and/or psychiatric illness can occur through the pathways of altered environmental sensitivity, impulsivity, social functioning, and anxious responding. While these traits are also heritable, environmental conditions are known to play a critical role. The genetic factors that contribute t...

journal_title：Neuroscience research

authors： Driscoll CA,Barr CS

更新日期：2016-01-01 00:00:00

abstract：:We generated a transgenic rat strain with a missense mutation in V286L (V286L-TG), in the gene encoding the neuronal nicotinic acetylcholine receptor β2 subunit (CHRNB2) found in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To confirm that V286L-TG rats exhibit seizures similar to those o...

journal_title：Neuroscience research

authors： Shiba Y,Mori F,Yamada J,Migita K,Nikaido Y,Wakabayashi K,Kaneko S,Okada M,Hirose S,Ueno S

更新日期：2015-11-01 00:00:00

abstract：:This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of ...

journal_title：Neuroscience research

authors： Castilla-Ortega E,Rosell-Valle C,Blanco E,Pedraza C,Chun J,Rodríguez de Fonseca F,Estivill-Torrús G,Santín LJ

更新日期：2013-11-01 00:00:00

abstract：:It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...

journal_title：Neuroscience research

authors： Baginskas A,Kuraite V,Kuras A

更新日期：2012-09-01 00:00:00