Abstract：
:This study was designed to evaluate the anticonvulsant effects of imperatorin (a furanocoumarin isolated from fruits of Angelica archangelica) in the mouse maximal electroshock seizure threshold model. The threshold for electroconvulsions in mice was determined at several times: 15, 30, 60 and 120 min after i.p. administration of imperatorin at increasing doses of 10, 20, 30, 40, 50 and 100 mg/kg. The evaluation of time-course relationship for imperatorin in the maximal electroshock seizure threshold test revealed that the agent produced its maximum antielectroshock action at 30 min after its i.p. administration. In this case, imperatorin at doses of 50 and 100 mg/kg significantly raised the threshold for electroconvulsions in mice by 38 and 68% (P<0.05 and P<0.001), respectively. The antiseizure effects produced by imperatorin at 15, 60 and 120 min after its systemic (i.p.) administration were less expressed than those observed for imperatorin injected 30 min before the maximal electroshock seizure threshold test. Based on this study, one can conclude that imperatorin produces the anticonvulsant effect in the maximal electroshock seizure threshold test in a dose-dependent manner.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Luszczki JJ,Glowniak K,Czuczwar SJdoi
10.1016/j.neures.2007.05.004subject
Has Abstractpub_date
2007-09-01 00:00:00pages
18-22issue
1eissn
0168-0102issn
1872-8111pii
S0168-0102(07)00180-0journal_volume
59pub_type
杂志文章abstract：:The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.09.007
更新日期：2006-12-01 00:00:00
abstract：:This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.09.004
更新日期：2013-11-01 00:00:00
abstract：:To detect the release of nitric oxide (NO) in brain tissue, an electrochemical microprobe was developed. The output current of the probe correlated linearly with the NO concentration at the tip, and the sensitivity of the probe was between 3.5 and 106 pA per 1 microM change in NO concentration. This probe showed no se...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90048-j
更新日期：1990-09-01 00:00:00
abstract：:Spinal cord injury (SCI) is a serious condition often affecting young and healthy individuals around the world. Electro-acupuncture (EA) has been proven to contribute towards neurologic and functional recoveries in SCI, but the underlying mechanism remains largely unknown especially regarding neural specific proteins ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.04.012
更新日期：2010-08-01 00:00:00
abstract：:Stem cell-based therapy has recently offered a promising alternative for the remedy of neurodegenerative disorders like Huntington's disease (HD). Herein, we investigated the potential ameliorative effects of implantation of dental pulp stem cells (DPSCs) in 3-nitropropionic acid (3-NP) rat models of HD. In this regar...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2020.12.002
更新日期：2020-12-22 00:00:00
abstract：:Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are g...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.10.007
更新日期：2018-04-01 00:00:00
abstract：:Hippocampal neurogenesis is influenced by many factors. In this study, we examined the effect of tactile stimulation (tickling), which induced positive emotion, on neurogenesis in the dentate gyrus (DG) of the hippocampus. Four week-old rats were tickled for 5 min/day on 5 consecutive days and received 5-bromo-2'-deox...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.09.001
更新日期：2010-12-01 00:00:00
abstract：:We previously showed that our neural stem sphere (NSS) method promotes the neuronal differentiation of mouse, monkey and human embryonic stem (ES) cells. Here we analyzed changes in expression of marker genes and proteins during neuronal differentiation. When cultured in astrocyte-conditioned medium (ACM) under free-f...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.12.014
更新日期：2011-04-01 00:00:00
abstract：:Environmental factors during perinatal period have various effects on behavior. The present study examined the effects of prenatal stress and neonatal handling on anxiety and spatial learning of offspring. Prenatal stress increased anxiety-related behavior of adult offspring, whereas neonatal handling had no effect. I...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.07.002
更新日期：2015-12-01 00:00:00
abstract：:Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury. In the present study, we examined the possibility that the n...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00184-6
更新日期：2003-10-01 00:00:00
abstract：:Properties of the Ca2+ -activated K+ current (I[K(Ca)]) were investigated in bipolar cells isolated from the goldfish retina. Pharmacological experiments and single channel current recordings demonstrated that I[K(Ca)] represented currents through BK channels, which were confined mostly to the presynaptic terminal. Th...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)01155-3
更新日期：1997-03-01 00:00:00
abstract：:The effects of acupuncture-like stimulation of the various segmental areas on gastric motility were examined in anesthetized rats. An acupuncture needle (diameter 340 microns) was inserted into the skin and underlying muscles at a depth of 4-5 mm and was twisted right and left once every second for 60 s. Gastric motil...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90105-y
更新日期：1993-10-01 00:00:00
abstract：:The cerebellar Purkinje cell has highly branched dendrites extending in a transverse plane to the cerebellar folium. Branching patterns of the dendrites were subjected to fractal analysis to obtain a quantitative measure of their intricacy. Using a square-covering method, we found that dendrites have a statistical sel...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90031-7
更新日期：1992-02-01 00:00:00
abstract：:Over the last few decades, motor imagery has attracted the attention of researchers as a prototypical example of 'embodied cognition' and also as a basis for neuro-rehabilitation and brain-machine interfaces. The current definition of motor imagery is widely accepted, but it is important to note that various abilities...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2015.11.003
更新日期：2016-03-01 00:00:00
abstract：:It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2012.07.002
更新日期：2012-09-01 00:00:00
abstract：:To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus fol...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.11.007
更新日期：2007-03-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive degeneration of motoneurons. We have demonstrated that hepatocyte growth factor (HGF) attenuates loss of both spinal and brainstem motoneurons of ALS model mice expressing mutated human SOD1(G93A) (G93A). This study was designed to ass...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.06.016
更新日期：2009-10-01 00:00:00
abstract：:In this review, we describe recent experimental observations and model simulations in the research subject of brain-machine interface (BMI). Studies of BMIs have applied decoding models to extract functional characteristics of the recorded neurons, and some of these have more focused on adaptation based on neural oper...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2020.03.008
更新日期：2020-07-01 00:00:00
abstract：:Temporal changes in kainate-induced seizure activity and hippocampal NO generation were evaluated simultaneously in conscious rats by using in vivo microdialysis and by determining the concentrations of nitrite and nitrate in perfusates. Intraperitoneal injection of kainic acid produced 'wet dog shake', focal seizure ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00086-8
更新日期：1998-11-01 00:00:00
abstract：:The effects of substance P (SP) on cholinergic transmission were studied at the neuromuscular junction of frogs by intracellular and voltage-clamp recording methods. Bath application of SP increased the amplitude of end-plate potential (e.p.p.) evoked in either low-Ca2+ -high Mg2+ or curare-containing solution. SP at ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(86)90020-9
更新日期：1986-05-01 00:00:00
abstract：:Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2017.02.004
更新日期：2017-07-01 00:00:00
abstract：:Distribution of the delta- and epsilon-subspecies of protein kinase C (PKC) in rat central nervous tissues was semiquantitated by an immunoblot analysis. The epsilon-subspecies, which is expressed predominantly in the brain, was abundant in hippocampus and cerebral cortex among rat brain areas, whereas the delta-subsp...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90047-7
更新日期：1994-05-01 00:00:00
abstract：:The subiculum is one of output structures of the hippocampal formation and plays a pivotal role in learning and memory. Because its morphological features are less investigated than those of the hippocampus proper, we explored the internal structure of the rat subiculum using immunohistochemistry. The septal subiculum...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.02.001
更新日期：2020-01-01 00:00:00
abstract：:The intent of the present study is to define the brainstem nuclei which give rise to CGRP-immunolabeled afferents to the inferior olivary complex of the mouse. A technique which combines retrograde transport of fluorescent microspheres with immunohistochemistry was used to address this question. In the present study, ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00045-0
更新日期：1999-08-01 00:00:00
abstract：:The distribution of ryanodine receptor-like immunoreactivity in the mouse central nervous system was studied using two antibodies raised against synthetic peptides. These peptides represented a region conserved between the cardiac and skeletal muscle forms and a region specific to the cardiac form. Western blotting an...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90026-9
更新日期：1992-10-01 00:00:00
abstract：:We studied the patterns of membrane potential changes in vocal cord tensor motoneurons, i.e. cricothyroid muscle motoneurons (CTMs), during fictive breathing, vocalization, coughing, and swallowing in decerebrate paralyzed cats to determine the nature of central drives to CTMs during these behaviors. CTMs were identif...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.03.009
更新日期：2004-07-01 00:00:00
abstract：:Saccadic eye movement is a rapid shift of eye position to capture an object in the environment. In this study, we will describe the fundamental properties of spontaneously evoked saccade-like rapid eye movement (SLREM) in mice in order to establish the mouse experimental model for studying saccades. Spontaneous SLREM ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.04.003
更新日期：2007-07-01 00:00:00
abstract：:Medial preoptic area (MPA), supraoptic nucleus (SON), magnocellular (MaPVN) and parvocellular (PaPVN) paraventricular hypothalamic nuclei, and mesencephalic lateral tegmentum (MLT) are involved in maternal behavior, parturition and lactation. This study investigated the FosB and Fos immunoreactivity in these regions o...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00100-x
更新日期：1998-12-01 00:00:00
abstract：:Mutations in the dynamin family GTPase OPA1 are reportedly the cause of autosomal dominant optic atrophy, the most frequently occurring form of hereditary optic neuropathy. But although the involvement of structural abnormalities of the enzyme in this neurodegenerative disease is clear, little is known about the cell ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.02.010
更新日期：2006-06-01 00:00:00
abstract：:A study was made of the effects of taurine on GABArho1 receptors expressed in Xenopus oocytes. The EC(50) and reversal potentials for GABA, taurine and glycine currents were 2.3+/-0.4 microM (-25+/-0.9 mV), 5+/-0.8mM (-27+/-0.4 mV) and 7+/-0.5mM (-22+/-0.6 mV), respectively. Co-application of GABA and taurine, reveale...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.03.009
更新日期：2008-07-01 00:00:00
