Abstract：
:Changes in the expression of estrogen-related substances in monkeys' brains at the menopausal transition, when estrogen deficit starts to occur, have not yet been examined thoroughly. In the present study, we immunohistochemically investigated the expression levels of estrogen receptor beta (ERβ) and aromatase (local estrogen synthesizing enzyme) in the hippocampal formation of premenopausal, menopausal, and ovariectomized premenopausal monkeys. In all monkeys tested, ERβ immunoreactivity was observed in interneurons located in the subiculum and the Ammon's horn, and most of these ERβ-immunoreactive neurons coexpressed a GABAergic neuron marker, parvalbumin. In the menopausal monkeys who exhibited a decline in estrogen concentration, hippocampal ERβ was highly upregulated, while aromatase expression was not markedly changed. By contrast, aromatase in the ovariectomized monkeys was significantly upregulated, while ERβ expression was not changed. In the brains of ovariectomized and menopausal monkeys, depletion of ovary-derived estrogen brought about different reactions which may be attributed to the senescence of brain aging.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Higaki S,Takumi K,Itoh M,Watanabe G,Taya K,Shimizu K,Hayashi M,Oishi Tdoi
10.1016/j.neures.2011.10.007subject
Has Abstractpub_date
2012-02-01 00:00:00pages
148-54issue
2eissn
0168-0102issn
1872-8111pii
S0168-0102(11)02112-2journal_volume
72pub_type
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