Abstract：
:Subcortical vascular dementia (SVD) is a small vessel disease with dementia that exhibits relatively uniform clinical and pathological features and constitutes approximately half of vascular dementia (VaD) cases. This subtype is further classified into Binswanger's disease and multiple lacunar infarctions. The former is characterized by diffuse white matter lesions, and the latter is characterized by lacunar infarctions. Both of these entities are related to hypertensive small vessel changes. Subcortical vascular dementia may exhibit slowly progressive vascular Parkinsonism and dementia but can be differentiated from Alzheimer's disease because it is associated with more extensive white matter lesions, less severe hippocampal atrophy and the absence of cerebral amyloid angiopathy (CAA), which may be indicated radiologically by lobar microbleeds, cortical subarachnoid hemorrhage (SAH) and cortical microinfarctions. Cerebral amyloid angiopathy may manifest as dementia and constitute the cortical type counterpart of SVD in small vessel disease with dementia. This paper provides an overview of the clinical features, pathogenesis and treatment for SVD, as well as its relationship to CAA and Alzheimer's disease.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Tomimoto Hdoi
10.1016/j.neures.2011.07.1820subject
Has Abstractpub_date
2011-11-01 00:00:00pages
193-9issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(11)02003-7journal_volume
71pub_type
杂志文章,评审abstract：:Our purpose was to elucidate the functional roles of the laryngeal afferents in controlling vocalization. We investigated the effects of laryngeal deafferentation (sectioning the internal branch of the superior laryngeal nerve (ISLN)) on respiration and voice quality during electrically-induced vocalization in twelve ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00877-v
更新日期：1995-03-01 00:00:00
abstract：:Prepulse inhibition (PPI) and habituation of the acoustic startle reflex (ASR) are considered to be candidate endophenotypes of schizophrenia. However, to our knowledge, only one group has investigated these startle measures in Asian patients with schizophrenia. In the present study, we evaluated these startle measure...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.08.006
更新日期：2008-11-01 00:00:00
abstract：:Nandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal gro...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.09.001
更新日期：2020-09-01 00:00:00
abstract：:1-methyl-4-phenylpyridinium ion (MPP(+)), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of intracellular reactive oxygen species (ROS) level and apoptotic death. Salvianic acid A (SA), isolated from the Chinese...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2004.10.001
更新日期：2005-02-01 00:00:00
abstract：:To identify corticotropin releasing factor (CRF)- and galanin (GAL)-containing neurons projecting to the median eminence, a retrograde tracing method with True blue was combined with a double-staining method. It was demonstrated that some True blue-labeled CRF neurons in the paraventricular nucleus were also immunorea...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(92)90073-l
更新日期：1992-09-01 00:00:00
abstract：:We studied developmental changes in respiratory-like C4 activity and respiratory-related neurons in the ventrolateral medulla (VLM) of brainstem-spinal cord preparations from rat fetuses after embryonic day 16 (E16). In addition to respiratory nerve activity, non-respiratory activity was recorded from the C4 ventral r...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00322-4
更新日期：2002-03-01 00:00:00
abstract：:Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.02.003
更新日期：2014-04-01 00:00:00
abstract：:Eugenol modulates neuronal activity through actions on voltage-gated ionic channels and/or transient receptor potential channels. We previously suggested that eugenol inhibited cellular (and/or network) mechanisms essential for the maintenance of the respiratory burst activity in a brainstem-spinal cord preparation fr...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.06.001
更新日期：2020-06-01 00:00:00
abstract：:Epidemiological studies have shown that maternal infection during early pregnancy increases the risk of neurodevelopmental disorders (i.e., schizophrenia or autism) in offspring. Recently, diagnostic/stratification biomarkers for the maternal immune activation background in patients with neurodevelopmental disorders h...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2016.07.003
更新日期：2016-12-01 00:00:00
abstract：:The present study focused on the early stages of acute glutamate (L-Glu)-induced neurotoxic mechanisms, both biochemical, e.g. intracellular reactive oxygen species (ROS) and associated parameters as well as gene expression of cell survival/death pathways, i.e. Bcl-2 and caspases. Stereotactic intracortical injections...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.11.009
更新日期：2010-03-01 00:00:00
abstract：:Motor imagery (MI) is a mental practice that reproduces the visual- and/or kinesthetic-modality brain activations accompanying movement. It is a useful rehabilitation technique as the affected motor cortex can be stimulated in patients with stroke and hemiplegia. However, most patients with stroke have difficulty with...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.10.002
更新日期：2018-08-01 00:00:00
abstract：:T-type Ca2+ channel-dependent long-term potentiation (LTP) occurs predominantly during the critical period of ocular dominance plasticity in rat and cat visual cortex. Noradrenaline and serotonin are known to facilitate ocular dominance plasticity. In this study using rat visual cortical slices, we tested whether this...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.02.014
更新日期：2009-06-01 00:00:00
abstract：:While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synth...
journal_title：Neuroscience research
pub_type： 临床试验,杂志文章
doi：10.1016/s0168-0102(02)00007-x
更新日期：2002-04-01 00:00:00
abstract：:Since the first analysis of the Drosophila courtship song more than 50 years ago, the molecular and neural mechanisms underlying the acoustic communication between fruit flies has been studied extensively. The results of recent studies utilizing a wide array of genetic tools provide novel insights into the anatomic an...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:We have previously shown that endothelin-B receptor stimulation increases neural progenitor proliferation, partly in G(i) and extracellular matrix molecule-dependent manner. In the present study, we investigated whether G(q/11) is also involved in this response and how G(i) and G(q/11) might regulate the extracellular...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.06.1478
更新日期：2007-10-01 00:00:00
abstract：:The contribution of intrinsic balance control factors to fall mechanisms has received little investigation in studies on occupational accidents. The aim of this study was to assess whether postural regulation in falling workers might have specificities in terms of sensorimotor strategies and neuromuscular responses to...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.11.001
更新日期：2004-03-01 00:00:00
abstract：:Changes in the expression of estrogen-related substances in monkeys' brains at the menopausal transition, when estrogen deficit starts to occur, have not yet been examined thoroughly. In the present study, we immunohistochemically investigated the expression levels of estrogen receptor beta (ERβ) and aromatase (local ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.10.007
更新日期：2012-02-01 00:00:00
abstract：:A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.05.001
更新日期：2011-08-01 00:00:00
abstract：:The effects of 5-HT3-receptor-related agents on long-term potentiation (LTP) in the mossy fiber-CA3 system were studied in guinea pig hippocampal slices. 5-HT3 receptor agonists, 1-(m-chlorophenyl)-biguanide (mCPBG) and 2-methyl serotonin (2-Me-5-HT) significantly attenuated the magnitude of LTP of the population spik...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90163-5
更新日期：1994-01-01 00:00:00
abstract：:Using median nerve injury and immunocytochemical methods, we examined the temporal changes in neuropeptide Y (NPY) expression in the cuneate nucleus (CN) in rats following median nerve transection. Under normal circumstances, neuropeptide Y-immunoreactive (NPY-IR) fibers was not detectable in the CN. A few NPY-IR fibe...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2003.12.003
更新日期：2004-04-01 00:00:00
abstract：:Acetylcholinesterase (AChE) activity is increased within and around amyloid plaques, which are present in Alzheimer's disease (AD) patient's brain. In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzy...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00201-8
更新日期：2003-01-01 00:00:00
abstract：:Hypnosis often leads people to obey a suggestion of movement and to lose perceived voluntariness. This inexplicable phenomenon suggests that the state of the motor system may be altered by hypnosis; however, objective evidence for this is still lacking. Thus, we used transcranial magnetic stimulation of the primary mo...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.05.009
更新日期：2014-08-01 00:00:00
abstract：:Saccadic eye movement is a rapid shift of eye position to capture an object in the environment. In this study, we will describe the fundamental properties of spontaneously evoked saccade-like rapid eye movement (SLREM) in mice in order to establish the mouse experimental model for studying saccades. Spontaneous SLREM ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.04.003
更新日期：2007-07-01 00:00:00
abstract：:Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00036-6
更新日期：2002-07-01 00:00:00
abstract：:By combining biochemical, molecular and immunohistochemical approaches, we have investigated the presence of metabotropic glutamate receptors (mGluRs) belonging to the subtype 5 in rat and human spinal cords and the developmental changes in their expression. A polyclonal antibody raised against the carboxy-terminal po...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(97)01175-9
更新日期：1997-05-01 00:00:00
abstract：:Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(02)00025-1
更新日期：2002-06-01 00:00:00
abstract：:Using high resolution spectral methods to uncover neuromarkers of social, cognitive and behavioral function, we have found that hemi-lateralized pairs of oscillations such as left and right occipital alpha or left and right rolandic mu dissociate spectrally. That is, they show a shifted frequency distribution, with on...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.12.006
更新日期：2020-07-01 00:00:00
abstract：:Chronic muscular limb pain requires the adoption of motor patterns distinct from the classic ipsilateral flexion, crossed extension and corresponding reciprocal inhibitions to acute exteroceptive stimulation. Using selective chemical activation of group III/IV afferents in gastrocnemius-soleus (GS) muscles we investig...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2015.01.003
更新日期：2015-06-01 00:00:00
abstract：:Dynamic binding of different brain areas is critical for various cognitive functions. The thalamic reticular nucleus (TRN) is a GABAergic nucleus that constrains information flow through thalamocortical loop by providing inhibitory innervation to the thalamus. In this review, I summarize anatomical and single-cell-lev...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2019.12.004
更新日期：2020-07-01 00:00:00
abstract：:Close relationships between the nervous system and immune systems at molecular levels have now become evident. Receptors for CDF/LIF and CNTF, i.e., factors which play important roles in the nervous system, share a close structural similarity to those for IL-6, which is a molecule acting in the immune system. Receptor...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(92)90001-s
更新日期：1992-11-01 00:00:00
