An aromatic substance, eugenol induces distinct depressant effects on respiratory activity in different postnatal developmental stages of the rat.

Abstract:

:Eugenol modulates neuronal activity through actions on voltage-gated ionic channels and/or transient receptor potential channels. We previously suggested that eugenol inhibited cellular (and/or network) mechanisms essential for the maintenance of the respiratory burst activity in a brainstem-spinal cord preparation from newborn rat (postnatal day 0-3). Study of the distinct effects of eugenol in neonatal and later developmental stage rats may offer new information about postnatal developmental changes of respiratory neuron networks. In the present study, therefore, we compared effects of eugenol in an in vitro newborn rat preparation with those in an arterially perfused in situ preparation from juvenile rat (postnatal day 12-15). In the former preparation, application of 1 mM eugenol decreased respiratory rate and inspiratory burst duration. In contrast, in the latter preparation, 1 mM eugenol induced a gradual decrease in the amplitude of integrated phrenic nerve activity. Phrenic nerve activity gradually recovered at 25-30 min after washout with a burst duration similar to control values. We hypothesized that the depressant effects of eugenol were caused by inhibition of cell excitability in the neonatal rat in vitro preparation but by a reduction of synaptic interactions in the juvenile rat in situ preparation.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Kotani S,Yazawa I,Onimaru H,Izumizaki M

doi

10.1016/j.neures.2019.06.001

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

20-26

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(19)30170-1

journal_volume

155

pub_type

杂志文章
  • Effect of different spinal cord lesions on visually guided switching of target-reaching in cats.

    abstract::It has previously been shown that when a target is moved, cats can change the direction of ongoing target-reaching with brief latency suggesting a tectal relay. Switching of target-reaching has now been investigated after spinal lesions: (1) dorsally in C5 interrupting cortico- (CS) and rubrospinal (RS) fibres to fore...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(87)90023-x

    authors: Alstermark B,Górska T,Lundberg A,Pettersson LG,Walkowska M

    更新日期:1987-10-01 00:00:00

  • Unilateral lesions of mesostriatal dopaminergic pathway alters the withdrawal response of the rat hindpaw to mechanical stimulation.

    abstract::To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2005.01.005

    authors: Takeda R,Ikeda T,Tsuda F,Abe H,Hashiguchi H,Ishida Y,Nishimori T

    更新日期:2005-05-01 00:00:00

  • Sagittal organization of the olivocerebellonuclear pathway in the rat. II. Connections with the nucleus interpositus.

    abstract::The organization of the sagittal Zone C of the cerebellar cortex of the rat was studied with respect to its efferent projections and to its inferior olive (IO) afferent connections. Wheat-germ agglutinin conjugated to horseradish peroxidase was used as a tracer. Zone C has been defined as the cortical region projectin...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(88)90039-9

    authors: Buisseret-Delmas C

    更新日期:1988-08-01 00:00:00

  • Separate mechanisms of long-term potentiation in two input systems to CA3 pyramidal neurons of rat hippocampal slices as revealed by the whole-cell patch-clamp technique.

    abstract::Excitatory synaptic transmission from two input systems to hippocampal CA3 pyramidal neurons was investigated by the whole-cell patch-clamp technique for thin slice preparation, with special reference to long-term potentiation (LTP) in these systems. Excitatory postsynaptic currents (EPSCs) evoked by fimbrial stimulat...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(91)90070-f

    authors: Katsuki H,Kaneko S,Tajima A,Satoh M

    更新日期:1991-11-01 00:00:00

  • The effects of D-alpha-aminoadipic acid on long-term potentiation in the hippocampus of the rat in vitro.

    abstract::Many studies on long-term potentiation (LTP) in hippocampal region CA1 focus on receptor-mediated events that are often presumed to be linked to postsynaptic processes. Whereas it is now well-known that LTP consists of multiple components involving increases in postsynaptic responsiveness as well as enhanced presynapt...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(95)00986-8

    authors: Hicks TP,Ito KI

    更新日期:1996-01-01 00:00:00

  • Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1.

    abstract::Sleep disturbances are common in psychiatric disorders, but the causal relationship between the two and the underlying genetic factors is unclear. The DISC1 gene is strongly linked to mood disorders and schizophrenia in a Scottish pedigree. In an earlier study we found a sleep homeostasis disturbance in a Drosophila m...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2016.06.006

    authors: Jaaro-Peled H,Altimus C,LeGates T,Cash-Padgett T,Zoubovsky S,Hikida T,Ishizuka K,Hattar S,Mongrain V,Sawa A

    更新日期:2016-11-01 00:00:00

  • Coexistence of varying combinations of neuropeptides with 5-hydroxytryptamine in neurons of the raphe pallidus et obscurus projecting to the spinal cord.

    abstract::The coexistence of varying combinations of substance P (SP), somatostatin (SOM), thyrotropin-releasing hormone (TRH) and met-enkephalin-Arg-Gly-Leu (ENK) with 5-hydroxytryptamine (5-HT) as semiquantitatively revealed by immunocytochemistry in neuronal perikarya of the raphe pallidus et obscurus in the guinea-pig was a...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(89)90033-3

    authors: Chiba T,Masuko S

    更新日期:1989-10-01 00:00:00

  • Fractal dimension of dendritic tree of cerebellar Purkinje cell during onto- and phylogenetic development.

    abstract::The cerebellar Purkinje cell has highly branched dendrites extending in a transverse plane to the cerebellar folium. Branching patterns of the dendrites were subjected to fractal analysis to obtain a quantitative measure of their intricacy. Using a square-covering method, we found that dendrites have a statistical sel...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(92)90031-7

    authors: Takeda T,Ishikawa A,Ohtomo K,Kobayashi Y,Matsuoka T

    更新日期:1992-02-01 00:00:00

  • Self-reorganization of neuronal activation patterns in the cortex under brain-machine interface and neural operant conditioning.

    abstract::In this review, we describe recent experimental observations and model simulations in the research subject of brain-machine interface (BMI). Studies of BMIs have applied decoding models to extract functional characteristics of the recorded neurons, and some of these have more focused on adaptation based on neural oper...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2020.03.008

    authors: Ito H,Fujiki S,Mori Y,Kansaku K

    更新日期:2020-07-01 00:00:00

  • Expression of dopamine D1-receptor mRNA in the carotid body of adult rabbits, cats and rats.

    abstract::Dopamine is a major neurotransmitter in the carotid body of several animal species and its functional role at the level of peripheral arterial chemoreflex pathway is attributed to the presence of the dopamine D2-receptors. We present evidence that the dopamine D1-receptor mRNA is also expressed in the carotid body of ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(98)00033-9

    authors: Bairam A,Frenette J,Dauphin C,Carroll JL,Khandjian EW

    更新日期:1998-06-01 00:00:00

  • Nandrolone improve synaptic plasticity at the hippocampus CA1 area and spatial localization in the Morris water maze of male adolescent rats.

    abstract::Nandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal gro...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2019.09.001

    authors: Salimi Z,Khajehpour L,Moradpour F,Moazedi AA,Pourmotabbed A,Zarei F

    更新日期:2020-09-01 00:00:00

  • Myocardial nerve fibers are preserved in MPTP-treated mice, despite cardiac sympathetic dysfunction.

    abstract::Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Al...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2007.11.011

    authors: Amino T,Uchihara T,Tsunekawa H,Takahata K,Shimazu S,Mizusawa H,Orimo S

    更新日期:2008-03-01 00:00:00

  • Effects of nerve growth factor and nicotine on the expression of nicotinic acetylcholine receptor subunits in PC12 cells.

    abstract::The neuroprotective effect of nicotine via nicotinic acetylcholine receptor (nAChR) has been reported in differentiated PC12 cells. We examined the effects of nerve growth factor (NGF) and nicotine on the expressions of the nAChR subunits alpha3, alpha5, alpha7, beta2, beta3 and beta4, in PC12 cells using Northern blo...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(99)00064-4

    authors: Takahashi T,Yamashita H,Nakamura S,Ishiguro H,Nagatsu T,Kawakami H

    更新日期:1999-12-01 00:00:00

  • My thoughts through a robot's eyes: an augmented reality-brain-machine interface.

    abstract::A brain-machine interface (BMI) uses neurophysiological signals from the brain to control external devices, such as robot arms or computer cursors. Combining augmented reality with a BMI, we show that the user's brain signals successfully controlled an agent robot and operated devices in the robot's environment. The u...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.10.006

    authors: Kansaku K,Hata N,Takano K

    更新日期:2010-02-01 00:00:00

  • Effects of nocturnal bright light on saliva melatonin, core body temperature and sleep propensity rhythms in human subjects.

    abstract::Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26...

    journal_title:Neuroscience research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0168-0102(01)00310-8

    authors: Kubota T,Uchiyama M,Suzuki H,Shibui K,Kim K,Tan X,Tagaya H,Okawa M,Inoue S

    更新日期:2002-02-01 00:00:00

  • Saliency-guided neural prosthesis for visual attention: design and simulation.

    abstract::Recently the authors showed that a computational model of visual saliency could account for changes in gaze behavior of monkeys with damage in the primary visual cortex. Here we propose a neural prosthesis to restore eye gaze behavior by electrically stimulating the superior colliculus to drive visual attention. The s...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2013.07.007

    authors: Yoshida M,Veale R

    更新日期:2014-01-01 00:00:00

  • Merging advanced technologies with classical methods to uncover dendritic spine dynamics: A hot spot of synaptic plasticity.

    abstract::The structure of dendritic spines determines synaptic efficacy, a plastic process that mediates information processing in the vertebrate nervous system. Aberrant spine morphology, including alterations in shape, size, and number, are common in different brain diseases. Because of this, accurate and unbiased characteri...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2015.02.007

    authors: Maiti P,Manna J,McDonald MP

    更新日期:2015-07-01 00:00:00

  • Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats.

    abstract::Cytokines have been implicated in the etiology or pathology of various psychiatric diseases of developmental origin such as autism and schizophrenia. Leukemia inhibitory factor (LIF) is induced by a variety of brain insults and known to have many influences on mature and immature nervous system. Here, we assessed the ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2003.12.001

    authors: Watanabe Y,Hashimoto S,Kakita A,Takahashi H,Ko J,Mizuno M,Someya T,Patterson PH,Nawa H

    更新日期:2004-03-01 00:00:00

  • Radioprotective effect of epimedium on neurogenesis and cognition after acute radiation exposure.

    abstract::The radioprotective effect of herb epimedium (or yin yang huo) extract (5 g/kg, oral administration daily for 4 weeks) on neurogenesis and cognition after acute radiation exposure with 5.5 Gy was evaluated in Balb/c mice by behavioral tests and immunohistochemical study. The results indicated that epimedium extract co...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2018.08.011

    authors: Wang SW,Ren BX,Qian F,Luo XZ,Tang X,Peng XC,Huang JR,Tang FR

    更新日期:2019-08-01 00:00:00

  • Ultra-high olfactory sensitivity for the human sperm-attractant aromatic aldehyde bourgeonal in CD-1 mice.

    abstract::Recent studies have shown that certain aromatic aldehydes are ligands for olfactory receptors expressed in mammalian sperm cells and induce sperm chemotaxis. Using a conditioning paradigm, the olfactory sensitivity of five CD-1 mice for seven aromatic aldehydes was investigated. With all seven stimuli, the mice discri...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2011.08.009

    authors: Larsson L,Laska M

    更新日期:2011-12-01 00:00:00

  • Stimulus effects of the medial pontine reticular formation and the mesencephalic locomotor region upon medullary reticulospinal neurons in acute decerebrate cats.

    abstract::In acute decerebrate cats, medial pontine reticular formation (mPRF) and the mesencephalic locomotor region (MLR) were stimulated and their stimulus effects upon 250 medullary reticulospinal neurons (RSNs) were studied. One hundred and twenty-six RSNs were mono- and disynaptically activated. From the response patterns...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:

    authors: Iwakiri H,Oka T,Takakusaki K,Mori S

    更新日期:1995-08-01 00:00:00

  • Appearance of a fast inactivating voltage-dependent K+ currents in developing cerebellar granule cells in vitro.

    abstract::To elucidate the molecular mechanisms that regulate the maturation of action potential, we began by examining voltage-dependent K+ currents, known to contribute to the maturation of action potential, of developing granule cells in mouse cerebellar microexplant cultures. The migration of developing granule cells in thi...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)00099-0

    authors: Wakazono Y,Kurahashi T,Nakahira K,Nagata I,Takayama C,Inoue Y,Kaneko A,Ikenaka K

    更新日期:1997-12-01 00:00:00

  • Pharmacological evidence for two types of Ca2+-dependent K+-conductance in bullfrog sympathetic ganglion cells.

    abstract::The effect of apamin, a bee venom toxin, on the action potential and the spike after hyperpolarization was studied in bullfrog sympathetic ganglion cells. Apamin reduced the duration of the afterhyperpolarization but did not affect the maximum rates of rise and fall of Na+- and Ca2+-dependent action potentials. In the...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(85)90029-x

    authors: Koyano K,Abe T

    更新日期:1985-12-01 00:00:00

  • Coevolution of cytokine receptor families in the immune and nervous systems.

    abstract::Close relationships between the nervous system and immune systems at molecular levels have now become evident. Receptors for CDF/LIF and CNTF, i.e., factors which play important roles in the nervous system, share a close structural similarity to those for IL-6, which is a molecule acting in the immune system. Receptor...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/0168-0102(92)90001-s

    authors: Yamamori T,Sarai A

    更新日期:1992-11-01 00:00:00

  • Connections of the superior colliculus with the tegmentum and the cerebellum in the hedgehog tenrec.

    abstract::Different tracer substances were injected into the superior colliculus (CoS) in order to study its afferents and efferents with the meso-rhombencephalic tegmentum, the precerebellar nuclei and the cerebellum in the Madagascan hedgehog tenrec. The overall pattern of tectal connectivity in tenrec was similar to that in ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)00034-5

    authors: Künzle H

    更新日期:1997-06-01 00:00:00

  • RNA editing of the GABA(A) receptor alpha3 subunit alters the functional properties of recombinant receptors.

    abstract::RNA editing provides a post-transcriptional mechanism to increase structural heterogeneity of gene products. Recently, the alpha3 subunit of the GABAA receptors has been shown to undergo RNA editing. As a result, a highly conserved isoleucine residue in the third transmembrane domain is replaced with a methionine. To ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.01.003

    authors: Nimmich ML,Heidelberg LS,Fisher JL

    更新日期:2009-04-01 00:00:00

  • Immunohistochemical study on the neuronal diversity and three-dimensional organization of the mouse entopeduncular nucleus.

    abstract::The entopeduncular nucleus (EPN) is one of the major output nuclei of the basal ganglia in rodents. Previous studies have divided it into rostral and caudal halves, with the former containing somatostatin (SOM)-immunoreactive neurons and the latter dominated by parvalbumin (PV)-containing neurons, respectively. Howeve...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2015.02.006

    authors: Miyamoto Y,Fukuda T

    更新日期:2015-05-01 00:00:00

  • Survival and engraftment of mouse embryonic stem cell-derived implants in the guinea pig brain.

    abstract::alpha-Mannosidosis is a lysosomal storage disease resulting from a deficiency of the enzyme alpha-D-mannosidase. A major feature of alpha-mannosidosis is progressive neurological decline, for which there is no safe and effective treatment available. We have a guinea pig model of alpha-mannosidosis that models the huma...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2005.06.010

    authors: Robinson AJ,Meedeniya AC,Hemsley KM,Auclair D,Crawley AC,Hopwood JJ

    更新日期:2005-10-01 00:00:00

  • Glutamatergic neurons in the lateral periaqueductal gray innervate neurokinin-1 receptor-expressing neurons in the ventrolateral medulla of the rat.

    abstract::The neural pathways underlying the respiratory responses elicited by electrical or chemical stimulation of the lateral part of the periaqueductal gray (lPAG) remain unsettled. In the present study, we examined the lPAG projection to neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons in the ventrolateral medulla ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2012.08.001

    authors: Oka T,Yokota S,Tsumori T,Niu JG,Yasui Y

    更新日期:2012-10-01 00:00:00

  • Effect of isolation on classical conditioned histamine release in guinea pigs.

    abstract::To investigate the effect of abrupt or non-abrupt isolation stress on the classical conditioned histamine release, socially isolated or paired guinea pigs underwent conditioning procedures in which ovalbumin (OA) as an unconditioned stimulus (US) and dimethylsulfide (sulfur smelling) as a conditioned stimulus (CS) wer...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(02)00081-0

    authors: Irie M,Nagata S,Endo Y

    更新日期:2002-09-01 00:00:00