Abstract:
:Neonatal Brachial Plexus Palsy (NBPP) may lead to permanent impairment of arm function. As NBPP occurs when central motor programs develop, these may be ill-formed. We studied elbow flexion and motor imagery with fMRI to search for abnormal motor programming. We compared the cortical activity of adults with conservatively treated NBPP to that of healthy individuals stratified for hand dominance, using fMRI BOLD tasks of elbow flexion and motor imagery of flexion. Additionally, resting-state networks and regional gray matter volume were studied. Sixteen adult NBPP patients (seven men; median age 29 years) and sixteen healthy subjects (seven men, median age 27 years) participated. Cortical activation was significantly higher in patients during flexion imagery compared to healthy individuals and it increased with lesion extent and muscle weakness. The contralateral and ipsilateral premotor cortex, and the contralateral motor cortex showed stronger activity during imagined flexion in the right-handed NBPP subjects compared to healthy individuals. Activity patterns during actual flexion did not differ between groups. No differences in resting-state network connectivity or gray matter amount were found between the groups. NBPP affected imagined but not actual elbow flexion, suggesting an impairment of motor planning which would indicate abnormal motor programming in NBPP.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Anguelova GV,Rombouts SARB,van Dijk JG,Buur PF,Malessy MJAdoi
10.1016/j.neures.2017.05.001subject
Has Abstractpub_date
2017-10-01 00:00:00pages
19-26eissn
0168-0102issn
1872-8111pii
S0168-0102(16)30251-6journal_volume
123pub_type
杂志文章abstract::POZ/BTB proteins influence cellular development and in some examples act as oncoproteins. However, several POZ/BTB transcription factors have been found in terminally differentiated neurons, where their functions remain unknown. One example is NAC1, a constitutively-expressed protein that can regulate behaviors associ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00024-5
更新日期:2003-05-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive degeneration of motoneurons. We have demonstrated that hepatocyte growth factor (HGF) attenuates loss of both spinal and brainstem motoneurons of ALS model mice expressing mutated human SOD1(G93A) (G93A). This study was designed to ass...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.06.016
更新日期:2009-10-01 00:00:00
abstract::A time production test was performed in seven normal females and seven females with premenstrual syndrome (PMS). We used a time production test for six time intervals (6, 12, 24, 36, 48, 60 s). Time production tests were performed at 08:00, 14:00 and 20:00 h in the follicular, early luteal and late luteal phases (LLP)...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00290-5
更新日期:2001-12-01 00:00:00
abstract::Distribution of the delta- and epsilon-subspecies of protein kinase C (PKC) in rat central nervous tissues was semiquantitated by an immunoblot analysis. The epsilon-subspecies, which is expressed predominantly in the brain, was abundant in hippocampus and cerebral cortex among rat brain areas, whereas the delta-subsp...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(94)90047-7
更新日期:1994-05-01 00:00:00
abstract::1-methyl-4-phenylpyridinium ion (MPP(+)), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of intracellular reactive oxygen species (ROS) level and apoptotic death. Salvianic acid A (SA), isolated from the Chinese...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.10.001
更新日期:2005-02-01 00:00:00
abstract::Mature rat spinal cord cDNA libraries constructed in lambda gt10 and lambda ZAPII were screened with an oligonucleotide probe (39 mer), and 4 clones that possess DNA-inserts encoding a glycine receptor subunit were obtained. The cloned cDNAs were used to reconstruct the nucleotide sequence of the full-length open read...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90064-6
更新日期:1991-06-01 00:00:00
abstract::This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrogra...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00245-0
更新日期:2001-08-01 00:00:00
abstract::In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We specifically focus on recent developments in recording and stimula...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2013.10.001
更新日期:2014-01-01 00:00:00
abstract::Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.08.003
更新日期:2006-12-01 00:00:00
abstract::Education involves learning new information and acquiring cognitive skills. These require various cognitive processes including learning, memory, and language. Since cognitive processes activate associated brain areas, we proposed that the brains of elderly people with longer education periods would show traces of rep...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2014.12.009
更新日期:2015-05-01 00:00:00
abstract::Single units of the adrenal sympathetic nerve (n = 46) were dissected and characterized with respect to tonic discharge and response to cutaneous and baroreceptor stimulation. The frequency of tonic discharge averaged 1.6 Hz and cardiovascular rhythmic modulation was observed in 53% of the units. The stimuli employed ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(84)80008-5
更新日期:1984-04-01 00:00:00
abstract::Resveratrol shows ability to eliminate prion replication, but the exact mechanism for prion eradication was not clear yet. Our previous studies demonstrate a downregulation of brain-derived nerve growth factor (BDNF) during prion infection, meanwhile recovery of cerebral nerve growth factor (NGF) level by resveratrol ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.12.019
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD). METHOD:EEGs were recorded from 22 AD patients and 23 age-matched healthy...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.06.009
更新日期:2008-10-01 00:00:00
abstract::Different tracer substances were injected into the superior colliculus (CoS) in order to study its afferents and efferents with the meso-rhombencephalic tegmentum, the precerebellar nuclei and the cerebellum in the Madagascan hedgehog tenrec. The overall pattern of tectal connectivity in tenrec was similar to that in ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00034-5
更新日期:1997-06-01 00:00:00
abstract::It has been postulated that horizontal cells (HCs) send feedback signals onto cones via a proton feedback mechanism, which generates the center-surround receptive field of bipolar cells, and color-opponent signals in many non-mammalian vertebrates. Here we used a strong pH buffer, HEPES, to reduce extracellular proton...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.01.008
更新日期:2012-04-01 00:00:00
abstract::Environmental factors during perinatal period have various effects on behavior. The present study examined the effects of prenatal stress and neonatal handling on anxiety and spatial learning of offspring. Prenatal stress increased anxiety-related behavior of adult offspring, whereas neonatal handling had no effect. I...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2015.07.002
更新日期:2015-12-01 00:00:00
abstract::The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.09.007
更新日期:2006-12-01 00:00:00
abstract::The cerebellar Purkinje cell has highly branched dendrites extending in a transverse plane to the cerebellar folium. Branching patterns of the dendrites were subjected to fractal analysis to obtain a quantitative measure of their intricacy. Using a square-covering method, we found that dendrites have a statistical sel...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(92)90031-7
更新日期:1992-02-01 00:00:00
abstract::The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.01.011
更新日期:2020-01-01 00:00:00
abstract::Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00025-1
更新日期:2002-06-01 00:00:00
abstract::In the present study, the ability of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in the hippocampus to enhance locomotor activity in rats was investigated by local infusion. Intraperitoneal injection of the selective 5-HT(2C) antagonist SB 242084 (1 mg/kg) significantly increased rats motor activity, while the effect...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(01)00215-2
更新日期:2001-05-01 00:00:00
abstract::The magnitude of long-term potentiation (LTP) was re-examined for monosynaptic transmission between mossy fibers and CA3 neurons in thin sections of the hippocampus of the guinea pig. Although an initial negative deflection in the field potential showed apparent short-term potentiation, this deflection was concluded t...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(86)90060-x
更新日期:1986-09-01 00:00:00
abstract::Injury to the central nervous system causes glial reactions, which eventually lead to the formation of a glial scar and inhibit axonal regeneration. The present study aimed to reduce the extent of glial scar formation in injured cerebral cortex using heparin hexasaccharide (6-mer) and octasaccharide (8-mer). A single ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.01.007
更新日期:2004-05-01 00:00:00
abstract::Transforming growth factor beta (TGF-beta) is an extracellular signaling molecule known to mediate programmed cell death (PCD) in the developing retina. In the present study, we investigated the expression profiles and activity levels of TGF-beta ligand and TGF-beta receptors (TbetaR) during the successive physiologic...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.07.002
更新日期:2006-10-01 00:00:00
abstract::Chemokines are a family of peptides originally identified as the factors regulating the migration of leukocytes in inflammatory and immune responses. Recently, they have been shown to be produced in the central and peripheral nervous systems under various pathological conditions and act on neuronal and glial cells. In...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.01.004
更新日期:2004-04-01 00:00:00
abstract::Pathological gambling (PG) is a non-substance based addiction that shares many behavioral and neural features with substance based addictions. However, in PG behavioral and neural changes are unlikely to be confounded by effects of acute or chronic drug exposure. Changes in reward based decision-making in particular i...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2014.09.008
更新日期:2015-01-01 00:00:00
abstract::The present study investigated the effect of nicotine exposure on gustatory plasticity in the nematode Caenorhabditis elegans. The chemotactic response of wild-type N2 nematodes pre-exposed to 100mM NaCl with 3.0mM nicotine was almost the same as that of mock-conditioned nematodes unexposed to NaCl; however, the respo...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2013.09.001
更新日期:2013-11-01 00:00:00
abstract::RNA editing provides a post-transcriptional mechanism to increase structural heterogeneity of gene products. Recently, the alpha3 subunit of the GABAA receptors has been shown to undergo RNA editing. As a result, a highly conserved isoleucine residue in the third transmembrane domain is replaced with a methionine. To ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.01.003
更新日期:2009-04-01 00:00:00
abstract::The organization of the sagittal Zone C of the cerebellar cortex of the rat was studied with respect to its efferent projections and to its inferior olive (IO) afferent connections. Wheat-germ agglutinin conjugated to horseradish peroxidase was used as a tracer. Zone C has been defined as the cortical region projectin...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(88)90039-9
更新日期:1988-08-01 00:00:00
abstract::We have previously shown that endothelin-B receptor stimulation increases neural progenitor proliferation, partly in G(i) and extracellular matrix molecule-dependent manner. In the present study, we investigated whether G(q/11) is also involved in this response and how G(i) and G(q/11) might regulate the extracellular...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.06.1478
更新日期:2007-10-01 00:00:00