Zinc ion enhances the blocking potency of synthetic analogs of spider toxin (JSTX) on the glutamate receptor.

abstract：:We have generated a transgenic mouse model in which astrocytes express an enhanced green fluorescent protein (EGFP) under the control of the mouse glial fibrillary acidic protein (GFAP) promoter. EGFP, which is characteristically found throughout the cell, was expressed in these animals even in astrocytic fine process...

journal_title：Neuroscience research

authors： Suzuki R,Watanabe J,Arata S,Funahashi H,Kikuyama S,Shioda S

更新日期：2003-12-01 00:00:00

abstract：:This study evaluates the efficacy of mifepristone on weight restoration in rats subjected to dietary restriction and methylphenidate administration. 25 female rats aged between 9 and 12 months were divided into 2 groups: 5 controls (exposed only to dietary restriction) and 20 rats that were administered 5 mg/kg/d of m...

journal_title：Neuroscience research

authors： Bou Khalil R,Smayra V,Saliba Y,Hajal J,Bakhos JJ,Souaiby L,Richa S,Tamraz J,Farès N

更新日期：2018-10-01 00:00:00

abstract：:Although sleep is strongly implicated in memory consolidation, the molecular basis for the role of sleep in memory is not known. It has been established that the consolidation of hippocampus-dependent memory depends on the activation of the Erk1,2 MAP kinase (MAPK) pathway which activates de novo CRE-mediated transcri...

journal_title：Neuroscience research

authors： Xia Z,Storm D

更新日期：2017-05-01 00:00:00

abstract：:During brain development, neural stem cells change their competency to give sequential rise to neurons and glial cells. Expression of the basic helix-loop-helix (bHLH)-type cell-fate determination factors Ascl1, Olig2, and Hes1 is oscillatory in neural stem cells. Conversely, sustained expression of these factors medi...

journal_title：Neuroscience research

authors： Kageyama R,Shimojo H,Ohtsuka T

更新日期：2019-01-01 00:00:00

abstract：:Resveratrol shows ability to eliminate prion replication, but the exact mechanism for prion eradication was not clear yet. Our previous studies demonstrate a downregulation of brain-derived nerve growth factor (BDNF) during prion infection, meanwhile recovery of cerebral nerve growth factor (NGF) level by resveratrol ...

journal_title：Neuroscience research

authors： Hu C,Chen C,Chen J,Xiao K,Wang J,Shi Q,Ma Y,Gao LP,Wu YZ,Liu L,Xia Y,Yan P,Maimaitiming A,Zhou DH,Zhang LN,Chen ZB,Dong XP

更新日期：2021-01-01 00:00:00

abstract：:Maternal stress, viral infection, and obstetric complications, which trigger cytokine signaling, are hypothesized to be involved in schizophrenia and its related disorders. The etiologic contribution of individual cytokines to such psychiatric disorders, however, remains to be evaluated. To estimate the impact of peri...

journal_title：Neuroscience research

authors： Tohmi M,Tsuda N,Watanabe Y,Kakita A,Nawa H

更新日期：2004-09-01 00:00:00

abstract：:Eye movements were induced by stimulating the ventral bank of the anterior ectosylvian sulcus (AES) of chloralose-anesthetized cats. Intracortical microstimulation of this cortex evoked centering movements of both eyes. The latency of eye movement was 45 ms (range 40-60 ms) and the intensity of stimulation was 33 micr...

journal_title：Neuroscience research

authors： Tamai Y,Miyashita E,Nakai M

更新日期：1989-11-01 00:00:00

abstract：:NMDA receptors play an important functional role in the neuron excitability and plasticity. The conditions and consequences of their activation are of interest for many neuroscientists. This investigation was designed to explore an activation of the NMDA receptors of frog tectal neurons in vivo by a burst of spikes of...

journal_title：Neuroscience research

authors： Kuras A,Baginskas A,Batuleviciene V

更新日期：2006-04-01 00:00:00

abstract：:Properties of the Ca2+ -activated K+ current (I[K(Ca)]) were investigated in bipolar cells isolated from the goldfish retina. Pharmacological experiments and single channel current recordings demonstrated that I[K(Ca)] represented currents through BK channels, which were confined mostly to the presynaptic terminal. Th...

journal_title：Neuroscience research

authors： Sakaba T,Ishikane H,Tachibana M

更新日期：1997-03-01 00:00:00

abstract：:The contribution of intrinsic balance control factors to fall mechanisms has received little investigation in studies on occupational accidents. The aim of this study was to assess whether postural regulation in falling workers might have specificities in terms of sensorimotor strategies and neuromuscular responses to...

journal_title：Neuroscience research

authors： Vouriot A,Gauchard GC,Chau N,Benamghar L,Lepori ML,Mur JM,Perrin PP

更新日期：2004-03-01 00:00:00

abstract：:Distribution of the delta- and epsilon-subspecies of protein kinase C (PKC) in rat central nervous tissues was semiquantitated by an immunoblot analysis. The epsilon-subspecies, which is expressed predominantly in the brain, was abundant in hippocampus and cerebral cortex among rat brain areas, whereas the delta-subsp...

journal_title：Neuroscience research

authors： Matsushima S,Nakamura S

更新日期：1994-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) u...

journal_title：Neuroscience research

authors： Singh S,Kumar P

更新日期：2018-08-01 00:00:00

abstract：:Area TE sends dense projections to the perirhinal cortex in macaque monkeys, an area in which we previously observed flexible signals regarding upcoming reward outcomes during a conditional-association cued-reward task. To investigate neuronal processing during the generation of information on upcoming reward outcomes...

journal_title：Neuroscience research

authors： Ohyama K,Sugase-Miyamoto Y,Matsumoto N,Sato C,Shidara M

更新日期：2014-11-01 00:00:00

abstract：:Utilizing slice preparations of GAD67-GFP knock-in mouse, in which GABAergic neurons are specifically labeled with GFP fluorescence, we studied electrophysiological characteristics of GABAergic neurons of IC by whole-cell patch clamp-recording combined with biocytin-intracellular-staining techniques. GABAergic neurons...

journal_title：Neuroscience research

authors： Ono M,Yanagawa Y,Koyano K

更新日期：2005-04-01 00:00:00

abstract：:Pathological gambling (PG) is a non-substance based addiction that shares many behavioral and neural features with substance based addictions. However, in PG behavioral and neural changes are unlikely to be confounded by effects of acute or chronic drug exposure. Changes in reward based decision-making in particular i...

journal_title：Neuroscience research

authors： Wiehler A,Peters J

更新日期：2015-01-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) mRNA-positive cells were visualized by non-isotopic in situ hybridization histochemistry in the organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA) in gonadectomized juvenile female and male rats. In the rostral POA (rPOA) at the level of the anteroventr...

journal_title：Neuroscience research

authors： Ishihara T,Orikasa C,Araki T,Sakuma Y

更新日期：2002-06-01 00:00:00

abstract：:Cytokines have been implicated in the etiology or pathology of various psychiatric diseases of developmental origin such as autism and schizophrenia. Leukemia inhibitory factor (LIF) is induced by a variety of brain insults and known to have many influences on mature and immature nervous system. Here, we assessed the ...

journal_title：Neuroscience research

authors： Watanabe Y,Hashimoto S,Kakita A,Takahashi H,Ko J,Mizuno M,Someya T,Patterson PH,Nawa H

更新日期：2004-03-01 00:00:00

abstract：:Confocal laser scanning microscopy (CLSM) was used to record spatial and dynamic changes in the intracellular Ca2+ [(Ca2+]i) of bullfrog sympathetic ganglion cells in excised tissue or in culture. A CLSM utilizing Ar ion laser (488 nm) and recording fluo-3 fluorescence yielded the sliced image of ganglion cells, while...

journal_title：Neuroscience research

authors： Kuba K,Hua SY,Nohmi M

更新日期：1991-05-01 00:00:00

abstract：:Steroid hormones substantially influence brain development, reproduction sexual differentiation and emotion. These effects are mediated by steroid hormone receptors and cofactors, which directly regulate gene expression. Deciphering how and where these transcriptional activators occur in a cell provides the groundwork...

journal_title：Neuroscience research

authors： Kawata M,Matsuda K,Nishi M,Ogawa H,Ochiai I

更新日期：2001-07-01 00:00:00

abstract：:To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...

journal_title：Neuroscience research

authors： Takeda R,Ikeda T,Tsuda F,Abe H,Hashiguchi H,Ishida Y,Nishimori T

更新日期：2005-05-01 00:00:00

abstract：:Over the last few decades, motor imagery has attracted the attention of researchers as a prototypical example of 'embodied cognition' and also as a basis for neuro-rehabilitation and brain-machine interfaces. The current definition of motor imagery is widely accepted, but it is important to note that various abilities...

journal_title：Neuroscience research

authors： Hanakawa T

更新日期：2016-03-01 00:00:00

abstract：:To study the differences between peripheral nerve (PN) and embryonic homologous CNS structures as a conduit for CNS axons, spinal cord segments in neonatal rats were removed at the mid-thoracic level and PN or embryonic spinal cord (ESC) segments were grafted into the vacancy. Neural connections across the graft were ...

journal_title：Neuroscience research

authors： Asada Y,Kawaguchi S,Hayashi H,Nakamura T

更新日期：1998-07-01 00:00:00

abstract：:The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression. In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesi...

journal_title：Neuroscience research

authors： Alvarez-Erviti L,Couch Y,Richardson J,Cooper JM,Wood MJ

更新日期：2011-04-01 00:00:00

abstract：:Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein. This study evaluated the effect of N((omega))-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase inhibitor, on the behavior of rats bilaterally injected...

journal_title：Neuroscience research

authors： O'Hare E,Elliott JJ,Hobson P,O'Mara SM,Spanswick D,Kim EM

更新日期：2010-02-01 00:00:00

abstract：:Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a signific...

journal_title：Neuroscience research

authors： Nakamura TJ,Shinohara K,Funabashi T,Mitsushima D,Kimura F

更新日期：2001-09-01 00:00:00

abstract：:Slow disjunctive eye movement similar to ocular convergence was evoked by microstimulation in parts of the lateral suprasylvian area (LSA) in alert cats. A tungsten-in-glass microelectrode was used for stimulation, and eye movement was monitored using the magnetic search coil method. The velocity-versus-amplitude rela...

journal_title：Neuroscience research

authors： Toda H,Takagi M,Yoshizawa T,Bando T

更新日期：1991-10-01 00:00:00

abstract：:The organization of the sagittal Zone C of the cerebellar cortex of the rat was studied with respect to its efferent projections and to its inferior olive (IO) afferent connections. Wheat-germ agglutinin conjugated to horseradish peroxidase was used as a tracer. Zone C has been defined as the cortical region projectin...

journal_title：Neuroscience research

authors： Buisseret-Delmas C

更新日期：1988-08-01 00:00:00

abstract：:The chemical properties of probes that improve amyloid detection by non-invasive (19)F magnetic resonance imaging (MRI) are of interest. We synthesized benzoxazole compounds with trifluoromethoxy groups, and found that these compounds displayed sharp (19)F nuclear magnetic resonance (NMR) signals in an assay buffer. H...

journal_title：Neuroscience research

authors： Amatsubo T,Morikawa S,Inubushi T,Urushitani M,Taguchi H,Shirai N,Hirao K,Kato M,Morino K,Kimura H,Nakano I,Yoshida C,Okada T,Sano M,Tooyama I

更新日期：2009-01-01 00:00:00

abstract：:Chemokines related neuroinflammation and N-methyl-d-aspartate receptor (NMDAR) mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid-induced hyperalgesia (OIH), but little is known about specific mechanism and treatment. Chemokine CXCL12 with its receptor CXCR4 is implicated in diffe...

journal_title：Neuroscience research

authors： Li T,Wang H,Wang J,Chen Y,Yang C,Zhao M,Wang G,Yang Z

更新日期：2019-07-01 00:00:00

abstract：:Neuronal degeneration appears to be associated with changes in anti-ubiquitin immunoreactivity (UIR). To elucidate the relationship between the two events, we examined the time course of changes in UIR in pyramidal neurons of hippocampal organotypic cultures following exposure to an excitotoxin, N-methyl-D-aspartate (...

journal_title：Neuroscience research

authors： Okada M,Sakaguchi T,Kawasaki K

更新日期：1995-07-01 00:00:00