Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors.

abstract：:Visual-spatial navigation in familiar and unfamiliar environments is an essential requirement of daily life. Animal studies indicated the importance of the hippocampus for navigation. Neuroimaging studies demonstrated gender difference or strategies dependent difference of neural substrates for navigation. Using funct...

journal_title：Neuroscience research

authors： Ohnishi T,Matsuda H,Hirakata M,Ugawa Y

更新日期：2006-08-01 00:00:00

abstract：:Prepulse inhibition (PPI) and habituation of the acoustic startle reflex (ASR) are considered to be candidate endophenotypes of schizophrenia. However, to our knowledge, only one group has investigated these startle measures in Asian patients with schizophrenia. In the present study, we evaluated these startle measure...

journal_title：Neuroscience research

authors： Takahashi H,Iwase M,Ishii R,Ohi K,Fukumoto M,Azechi M,Ikezawa K,Kurimoto R,Canuet L,Nakahachi T,Iike N,Tagami S,Morihara T,Okochi M,Tanaka T,Kazui H,Yoshida T,Tanimukai H,Yasuda Y,Kudo T,Hashimoto R,Takeda M

更新日期：2008-11-01 00:00:00

abstract：:The effects of 5-HT3-receptor-related agents on long-term potentiation (LTP) in the mossy fiber-CA3 system were studied in guinea pig hippocampal slices. 5-HT3 receptor agonists, 1-(m-chlorophenyl)-biguanide (mCPBG) and 2-methyl serotonin (2-Me-5-HT) significantly attenuated the magnitude of LTP of the population spik...

journal_title：Neuroscience research

authors： Maeda T,Kaneko S,Satoh M

更新日期：1994-01-01 00:00:00

abstract：:Sizes of neuronal somata in the cat cervical dorsal root ganglia were determined at different levels (C1-C8). The average value and class distribution of mean cell diameter were analyzed. The ganglia from C1 to C5 could be clearly distinguished from those at levels of brachial plexus afferents (C6-C8) with respect to ...

journal_title：Neuroscience research

authors： Rose D,Larnicol N,Duron B

更新日期：1990-02-01 00:00:00

abstract：:Alcoholism is a psychiatric condition that develops through neuroadaptations in response to neuronal stresses caused by chronic ethanol intake. Neurons can adapt to ethanol-induced metabolic changes by activating cellular protective mechanisms, including autophagy. Here we show that expression of Ulk1, a gene critical...

journal_title：Neuroscience research

authors： Sumitomo A,Ueta K,Mauchi S,Hirai K,Horike K,Hikida T,Sakurai T,Sawa A,Tomoda T

更新日期：2017-04-01 00:00:00

abstract：:We developed a new method to visualize the myeloarchitecture in fresh slices, and investigated the properties of the functional neural connections around the boundary between the primary auditory cortex (area 41) and area 18a in rat cerebral slices. A fresh slice illuminated by near-vertical light was observed with a ...

journal_title：Neuroscience research

authors： Hishida R,Hoshino K,Kudoh M,Norita M,Shibuki K

更新日期：2003-06-01 00:00:00

abstract：:Recent rapid progress in genome analysis and large-scale consortia has made it possible to discover variants with a variety of allele frequencies and effect sizes associated with psychiatric disorders. Among psychiatric disorder-susceptibility variants, rare variants with large effect sizes detected by sequencing anal...

journal_title：Neuroscience research

authors： Kimura H,Mori D,Aleksic B,Ozaki N

更新日期：2020-12-11 00:00:00

abstract：:The distribution of a live attenuated herpes simplex virus (betaH1)-mediated gene delivery into the central nervous system (CNS) was regulated by growth inhibition with ganciclovir (GCV) and the effect of this transgene expression system on the physiologic response was characterized by the acoustic startle response an...

journal_title：Neuroscience research

authors： Fukuda Y,Yamamura J,Uwano T,Nishijo H,Kurokawa M,Fukuda M,Ono T,Shiraki K

更新日期：2003-02-01 00:00:00

abstract：:We studied developmental changes in respiratory-like C4 activity and respiratory-related neurons in the ventrolateral medulla (VLM) of brainstem-spinal cord preparations from rat fetuses after embryonic day 16 (E16). In addition to respiratory nerve activity, non-respiratory activity was recorded from the C4 ventral r...

journal_title：Neuroscience research

authors： Onimaru H,Homma I

更新日期：2002-03-01 00:00:00

abstract：:To investigate the functional organization in the monkey inferotemporal cortex, which is the last exclusively visual area along the ventral visual cortical pathway, optical imaging based on intrinsic signals was carried out. We first conducted single-cell recordings with microelectrodes and determined the features cri...

journal_title：Neuroscience research

authors： Wang G,Tanifuji M,Tanaka K

更新日期：1998-09-01 00:00:00

abstract：:While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synth...

journal_title：Neuroscience research

authors： Watanabe A,Kato N,Kato T

更新日期：2002-04-01 00:00:00

abstract：:To elucidate biophysical mechanisms underlying the Zn2+ block on the low-threshold T-type Ca2+ current (I(T)), we examined the Zn(2+)-induced alterations of gating properties of I(T) of a rat thalamic relay neuron and of alpha1G channels expressed in HEK-293 cells, using a whole-cell voltage clamp technique. The effec...

journal_title：Neuroscience research

authors： Noh J,Kim MK,Chung JM

更新日期：2010-04-01 00:00:00

abstract：:Swelling of brain cells is one of the physiological responses associated with neuronal activation. To investigate underlying mechanisms, we analyzed interactions between changes in cell volume and synaptic responses in the hippocampal slices from rodents. Swelling within the CA1 area was detected as increases in trans...

journal_title：Neuroscience research

authors： Takagi S,Obata K,Tsubokawa H

更新日期：2002-11-01 00:00:00

abstract：:Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26...

journal_title：Neuroscience research

authors： Kubota T,Uchiyama M,Suzuki H,Shibui K,Kim K,Tan X,Tagaya H,Okawa M,Inoue S

更新日期：2002-02-01 00:00:00

abstract：:In this communication, I first summarize the mechanisms underlying human voluntary movements and define the involuntary movements (medical term). CLASSIFICATION OF HUMAN MOVEMENTS:Human movements are classified into two main kinds: intentional movements and non-intentional movements in which the involuntary movements...

journal_title：Neuroscience research

authors： Ugawa Y

更新日期：2020-07-01 00:00:00

abstract：:Using standard intracellular recording techniques 38 nonpyramidal cells or interneurons have been sampled in hippocampal slices of the rat. Among 38 physiologically identified interneurons, all 27 cells labeled with biocytin were morphologically demonstrated to be nonpyramidal and nongranule cells. The vast majority o...

journal_title：Neuroscience research

authors： Han ZS

更新日期：1994-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a chronic and fatal disease, in which neuronal damage at its late stage cannot be easily reversed. Because AD progression is caused by multiple factors including diverse cellular processes, studies on AD pathogenesis at the molecular and cellular level are challenging. Based on the lessons ...

journal_title：Neuroscience research

authors： Chun H,Lee CJ

更新日期：2018-01-01 00:00:00

abstract：:Following neonatal hypoxia-ischemia (HI) serotonin (5-hydroxytryptamine, 5-HT) levels are decreased in the brain. The regulation of brain 5-HT is dependent on the serotonin transporter (SERT) localised at the neuronal pre-synaptic cell membrane. However SERT can also traffic away from the cell membrane into the cytoso...

journal_title：Neuroscience research

authors： Wixey JA,Reinebrant HE,Buller KM

更新日期：2012-07-01 00:00:00

abstract：:To study the contribution of retinal and cortical afferents to the patterns of glutamate- and homocysteate-like immunoreactivities in dorsal lateral geniculate, combined retinal and cortical ablations were performed in rats. In controls, glutamate immunoreactivity was in terminal-like dots and neurons. Homocysteate im...

journal_title：Neuroscience research

authors： Grandes P,Mateos JM,Azkue J,Sarría R,Cuénod M,Streit P

更新日期：1997-04-01 00:00:00

abstract：:Many different kinds of voltage-gated ion channels (Na+ channels, K+ channels, Ca2+ channels) exist at neuronal dendrites. Integration of dendritic electric signals (excitatory postsynaptic potentials (EPSPs), inhibitory postsynaptic potentials (IPSPs) and action potentials) and/or non-electric signals (Ca2+ and secon...

journal_title：Neuroscience research

authors： Takagi H

更新日期：2000-07-01 00:00:00

abstract：:TDP-43 pathology in motor neurons is a hallmark of ALS. In addition, the reduced expression of an RNA editing enzyme, adenosine deaminase acting on RNA 2 (ADAR2), increases the expression of GluA2 with an unedited Q/R site in the motor neurons of patients with sporadic ALS. As the occurrence of these two disease-speci...

journal_title：Neuroscience research

authors： Yamashita T,Hideyama T,Teramoto S,Kwak S

更新日期：2012-06-01 00:00:00

abstract：:Gene targeting to disrupt gene expression in a temporal and spatial manner in a specific tissue using Cre recombinase-mediated gene inactivation has been proven to be useful to study in vivo gene function. To delete genes specifically in neurons during the late phase of brain development, we have generated transgenic ...

journal_title：Neuroscience research

authors： Hirasawa M,Cho A,Sreenath T,Sauer B,Julien JP,Kulkarni AB

更新日期：2001-06-01 00:00:00

abstract：:Parkinson's disease (PD) is a multifactorial neurological disorder caused by selective dopaminergic neuronal loss. Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD. Rats were injected 6-OHDA (8μg/2μl, saline) u...

journal_title：Neuroscience research

authors： Singh S,Kumar P

更新日期：2018-08-01 00:00:00

abstract：:We previously showed that our neural stem sphere (NSS) method promotes the neuronal differentiation of mouse, monkey and human embryonic stem (ES) cells. Here we analyzed changes in expression of marker genes and proteins during neuronal differentiation. When cultured in astrocyte-conditioned medium (ACM) under free-f...

journal_title：Neuroscience research

authors： Otsu M,Sai T,Nakayama T,Murakami K,Inoue N

更新日期：2011-04-01 00:00:00

abstract：:Long-term depression at parallel fiber-Purkinje cell synapses plays a principal role in learning in the cerebellum, which acts as a supervised learning machine. Recent experiments demonstrate various forms of synaptic plasticity at different sites within the cerebellum. In this article, we take into consideration syna...

journal_title：Neuroscience research

authors： Yamazaki T,Lennon W

更新日期：2019-11-01 00:00:00

abstract：:Chemokines related neuroinflammation and N-methyl-d-aspartate receptor (NMDAR) mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid-induced hyperalgesia (OIH), but little is known about specific mechanism and treatment. Chemokine CXCL12 with its receptor CXCR4 is implicated in diffe...

journal_title：Neuroscience research

authors： Li T,Wang H,Wang J,Chen Y,Yang C,Zhao M,Wang G,Yang Z

更新日期：2019-07-01 00:00:00

abstract：:We examined the number and size of motoneurons and myelinated nerve fibers innervating the medial gastrocnemius (MG) muscle in the hindlimb of rats that were subjected to swimming for 10 months (30 min, 3 days/week) from 17 to 27 months of age. The number of MG motoneurons in exercised aged rats was slightly, but not ...

journal_title：Neuroscience research

authors： Kanda K,Hashizume K

更新日期：1998-05-01 00:00:00

abstract：:The influence of tooth loss on the viability of cholinergic neurons was examined in rats. At 25th postnatal week, rats were divided into the three groups; a control group fed a solid diet, a soft diet group fed a powder diet and a molar crown-less group in which all molar crowns were removed and the powder diet was gi...

journal_title：Neuroscience research

authors： Terasawa H,Hirai T,Ninomiya T,Ikeda Y,Ishijima T,Yajima T,Hamaue N,Nagase Y,Kang Y,Minami M

更新日期：2002-08-01 00:00:00

abstract：:In the rat striatum numerous secretagogin (SCGN) positive neurons were scattered. They were heterogeneous in their morphological and chemical properties. We examined the colocalization of SCGN with known four interneuron markers, parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and choline acetyl transfe...

journal_title：Neuroscience research

authors： Kosaka T,Yasuda S,Kosaka K

更新日期：2017-06-01 00:00:00

abstract：:The Madagascan lesser hedgehog tenrec was investigated to get insight into the areal evolution of the hippocampal formation in mammals with poorly differentiated brains. The hippocampal subdivisions were analyzed using cyto- and chemoarchitectural criteria; long associational and commissural connections were demonstra...

journal_title：Neuroscience research

authors： Künzle H,Radtke-Schuller S

更新日期：2001-11-01 00:00:00