Calcium-binding protein, secretagogin, characterizes novel groups of interneurons in the rat striatum.

Abstract:

:In the rat striatum numerous secretagogin (SCGN) positive neurons were scattered. They were heterogeneous in their morphological and chemical properties. We examined the colocalization of SCGN with known four interneuron markers, parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and choline acetyl transferase (ChAT). 60-70% of SCGN positive striatal neurons contained either PV or CR or ChAT, but none contained NOS. On the other hand the remaining 30-40% expressed none of these markers, most of which were GAD positive. The present study indicates that there are hitherto unknown groups of striatal interneurons in the rat striatum.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Kosaka T,Yasuda S,Kosaka K

doi

10.1016/j.neures.2017.01.004

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

53-60

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(16)30195-X

journal_volume

119

pub_type

杂志文章
  • Two groups of secondary vestibular neurons mediating horizontal canal signals, probably to the ipsilateral medial rectus muscle, under inhibitory influences from the cerebellar flocculus in rabbits.

    abstract::Vestibular nuclear neurons that mediate horizontal canal signals to the ipsilateral medial rectus motoneurons were explored in anesthetized and decerebrate rabbits. These neurons were identified by four criteria: (1) they were activated monosynaptically by ipsilateral vestibular nerve stimulation and (2) antidromicall...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(85)90016-1

    authors: Kawaguchi Y

    更新日期:1985-08-01 00:00:00

  • Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus.

    abstract::The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2006.09.007

    authors: Tsuchiya D,Kitamura Y,Takata K,Sugisaki T,Taniguchi T,Uemura K,Miki H,Takenawa T,Shimohama S

    更新日期:2006-12-01 00:00:00

  • Unmasking of silent "task-related" neuronal activity in the monkey prefrontal cortex by a GABA(A) antagonist.

    abstract::To examine the role of GABA on prefrontal neuronal activity in the control of behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was iontophoretically applied to prefrontal neurons while monkeys performed a visual reaction time task. Iontophoretic application of BMI uncovered "task-related" activit...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(00)00204-2

    authors: Sawaguchi T

    更新日期:2001-01-01 00:00:00

  • Immunocytochemical localization of heme oxygenase-2 in the rat cerebellum.

    abstract::Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). CO is generated by heme oxygenase during the conversion of heme to biliverdin. In this study, we raised an antiserum against the ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(96)01018-8

    authors: Yamanaka M,Yamabe K,Saitoh Y,Katoh-Semba R,Semba R

    更新日期:1996-03-01 00:00:00

  • Hypothalamic paraventricular nucleus stimulation enhances c-Fos expression in spinal and supraspinal structures related to pain modulation.

    abstract::The hypothalamic paraventricular nuclei (PVN) inhibits spinal nociception. Furthermore, projections from the PVN to other structures related to pain modulation exist, but a functional interaction has not yet been fully demonstrated. As an initial approach, we show here that PVN electric stimulation with the same param...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2015.04.004

    authors: Condés-Lara M,Martínez-Lorenzana G,Rubio-Beltrán E,Rodríguez-Jiménez J,Rojas-Piloni G,González-Hernández A

    更新日期:2015-09-01 00:00:00

  • Brief fear preexposure facilitates subsequent fear conditioning.

    abstract::Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs following an unexpected exposure to a severe psychological event. A history of a brief trauma is reported to affect a risk for future PTSD development; however, little is known about the mechanisms by which a previous trauma exposure drives the s...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2015.02.001

    authors: Iwasaki S,Sakaguchi T,Ikegaya Y

    更新日期:2015-06-01 00:00:00

  • Architecture of binocular disparity processing in monkey inferior temporal cortex.

    abstract::Neurons in the inferior temporal (IT) cortex respond not only to the shape, color or texture of objects, but to the horizontal positional disparity of visual features in the right and left retinal images. IT neurons with similar shape selectivity cluster in columns. In this study, we examined how IT neurons are spatia...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2003.10.008

    authors: Yoshiyama K,Uka T,Tanaka H,Fujita I

    更新日期:2004-02-01 00:00:00

  • Regulated transgene delivery by ganciclovir in the brain without physiological alterations by a live attenuated herpes simplex virus vector.

    abstract::The distribution of a live attenuated herpes simplex virus (betaH1)-mediated gene delivery into the central nervous system (CNS) was regulated by growth inhibition with ganciclovir (GCV) and the effect of this transgene expression system on the physiologic response was characterized by the acoustic startle response an...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(02)00235-3

    authors: Fukuda Y,Yamamura J,Uwano T,Nishijo H,Kurokawa M,Fukuda M,Ono T,Shiraki K

    更新日期:2003-02-01 00:00:00

  • Connectivity pattern changes in default-mode network with deep non-REM and REM sleep.

    abstract::Recent studies have compared default-mode network (DMN) connectivity in different arousal levels to investigate the relationship between consciousness and DMN. The comparison between the DMN in rapid eye movement (REM) sleep with that in non-REM (NREM) sleep is useful for revealing the relationship between arousal lev...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2010.12.018

    authors: Koike T,Kan S,Misaki M,Miyauchi S

    更新日期:2011-04-01 00:00:00

  • PC-based high-speed video-oculography for measuring rapid eye movements in mice.

    abstract::We newly developed an infrared video-oculographic system for on-line tracking of the eye position in awake and head-fixed mice, with high temporal resolution (240 Hz). The system consists of a commercially available high-speed CCD camera and an image processing software written in LabVIEW run on IBM-PC with a plug-in ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2004.02.002

    authors: Sakatani T,Isa T

    更新日期:2004-05-01 00:00:00

  • Where does slow axonal transport go?

    abstract::Axonal transport is the specialized and well-developed intracellular transport system for regulated and/or long-distance transport based on generalized cellular machineries. Among them, slow axonal transport conveys cytoplasmic proteins. The motor molecule, the nature of transporting complex and the transport regulati...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2003.08.005

    authors: Terada S

    更新日期:2003-12-01 00:00:00

  • Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors.

    abstract::In the present study, the ability of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in the hippocampus to enhance locomotor activity in rats was investigated by local infusion. Intraperitoneal injection of the selective 5-HT(2C) antagonist SB 242084 (1 mg/kg) significantly increased rats motor activity, while the effect...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(01)00215-2

    authors: Takahashi H,Takada Y,Urano T,Takada A

    更新日期:2001-05-01 00:00:00

  • Prophylactic active immunization with a novel epitope vaccine improves cognitive ability by decreasing amyloid plaques and neuroinflammation in APP/PS1 transgenic mice.

    abstract::Both amyloid-β peptide (Aβ) deposition and neuroinflammation are considered to be early events that play pivotal roles in Alzheimer's disease (AD) pathogenesis and its associated cognitive impairment. Prophylactic anti-Aβ active immunotherapy is a promising therapeutic strategy for AD, if the Aβ-specific autoimmune re...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2017.01.003

    authors: Ding L,Meng Y,Zhang HY,Yin WC,Yan Y,Cao YP

    更新日期:2017-06-01 00:00:00

  • Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.

    abstract::The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression. In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesi...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2010.12.020

    authors: Alvarez-Erviti L,Couch Y,Richardson J,Cooper JM,Wood MJ

    更新日期:2011-04-01 00:00:00

  • Bilateral intrahippocampal NAC61-95 effects on behavior and moderation with L-NAME treatment.

    abstract::Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein. This study evaluated the effect of N((omega))-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase inhibitor, on the behavior of rats bilaterally injected...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2009.11.002

    authors: O'Hare E,Elliott JJ,Hobson P,O'Mara SM,Spanswick D,Kim EM

    更新日期:2010-02-01 00:00:00

  • No evidence for interaction between 5-HT2A receptor and serotonin transporter genes in schizophrenia.

    abstract::This study was to aim at investigating the potential interaction for the serotonin receptor gene (5-HTR) 2A and serotonin transporter gene (5-HTTLPR) polymorphisms in the development of schizophrenia, as well as the interaction of the two polymorphisms in relation with symptomatology, family history, age of onset and ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2005.03.006

    authors: Pae CU,Artioli P,Serretti A,Kim TS,Kim JJ,Lee CU,Lee SJ,Lee C,Paik IH

    更新日期:2005-06-01 00:00:00

  • Haloperidol reduces the sympathetic and thermogenic activation induced by orexin A.

    abstract::This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley r...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(02)00191-8

    authors: Monda M,Viggiano A,De Luca V

    更新日期:2003-01-01 00:00:00

  • Effects of long-term physical exercise on age-related changes of spinal motoneurons and peripheral nerves in rats.

    abstract::We examined the number and size of motoneurons and myelinated nerve fibers innervating the medial gastrocnemius (MG) muscle in the hindlimb of rats that were subjected to swimming for 10 months (30 min, 3 days/week) from 17 to 27 months of age. The number of MG motoneurons in exercised aged rats was slightly, but not ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(98)00026-1

    authors: Kanda K,Hashizume K

    更新日期:1998-05-01 00:00:00

  • Light microscopic comparison of the patterns of glutamate-like and homocysteate-like immunoreactivities in rat dorsal lateral geniculate after combined visual cortical and retinal ablations.

    abstract::To study the contribution of retinal and cortical afferents to the patterns of glutamate- and homocysteate-like immunoreactivities in dorsal lateral geniculate, combined retinal and cortical ablations were performed in rats. In controls, glutamate immunoreactivity was in terminal-like dots and neurons. Homocysteate im...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)01162-0

    authors: Grandes P,Mateos JM,Azkue J,Sarría R,Cuénod M,Streit P

    更新日期:1997-04-01 00:00:00

  • Two different effects of transcranial magnetic stimulation to the human motor cortex during the pre-movement period.

    abstract::A single-pulse TMS to the human motor cortex (M1) influences reaction time (RT). We may summarize from previous studies where different groups of subjects participated in various types of RT tasks that TMS above motor threshold (MT) delays RT, whereas TMS below MT shortens RT and that these RT changes depends on TMS t...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2004.08.002

    authors: Hashimoto T,Inaba D,Matsumura M,Naito E

    更新日期:2004-12-01 00:00:00

  • Area dependent expression of ZNF312 in human fetal cerebral cortex.

    abstract::The human cerebral neocortex is divided into six layers consisting of specific neuronal cell types and connections. To determine the distribution of cortical neurons during early development, we examined the expressions of layer-specific markers in human midterm fetal brains. Layer V marker ZNF312 is expressed in most...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2010.05.007

    authors: Zhu H,Yang Y,Gao J,Tao H,Qu C,Qu J,Chen J

    更新日期:2010-09-01 00:00:00

  • Convergence of noxious and non-noxious cutaneous afferents and baroreceptor afferents onto single adrenal sympathetic neurons in anesthetized rats.

    abstract::Single units of the adrenal sympathetic nerve (n = 46) were dissected and characterized with respect to tonic discharge and response to cutaneous and baroreceptor stimulation. The frequency of tonic discharge averaged 1.6 Hz and cardiovascular rhythmic modulation was observed in 53% of the units. The stimuli employed ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(84)80008-5

    authors: Ito K,Sato A,Shimamura K,Swenson RS

    更新日期:1984-04-01 00:00:00

  • Studying longitudinal trajectories in animal models of psychiatric illness and their translation to the human condition.

    abstract::Many forms of psychopathology and/or psychiatric illness can occur through the pathways of altered environmental sensitivity, impulsivity, social functioning, and anxious responding. While these traits are also heritable, environmental conditions are known to play a critical role. The genetic factors that contribute t...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2015.08.001

    authors: Driscoll CA,Barr CS

    更新日期:2016-01-01 00:00:00

  • Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor.

    abstract::We generated a transgenic rat strain with a missense mutation in V286L (V286L-TG), in the gene encoding the neuronal nicotinic acetylcholine receptor β2 subunit (CHRNB2) found in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To confirm that V286L-TG rats exhibit seizures similar to those o...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2015.06.003

    authors: Shiba Y,Mori F,Yamada J,Migita K,Nikaido Y,Wakabayashi K,Kaneko S,Okada M,Hirose S,Ueno S

    更新日期:2015-11-01 00:00:00

  • Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.

    abstract::Effects of 1-naphthyl acetyl spermine (NASPM), a synthetic analogue of Joro spider toxin (JSTX), on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors were studied in cultured rat hippocampal neurons using the whole-cell patch clamp technique. A population of cultured neurons had ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)00067-9

    authors: Koike M,Iino M,Ozawa S

    更新日期:1997-09-01 00:00:00

  • Increased brain activation during motor imagery suggests central abnormality in Neonatal Brachial Plexus Palsy.

    abstract::Neonatal Brachial Plexus Palsy (NBPP) may lead to permanent impairment of arm function. As NBPP occurs when central motor programs develop, these may be ill-formed. We studied elbow flexion and motor imagery with fMRI to search for abnormal motor programming. We compared the cortical activity of adults with conservati...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2017.05.001

    authors: Anguelova GV,Rombouts SARB,van Dijk JG,Buur PF,Malessy MJA

    更新日期:2017-10-01 00:00:00

  • Arginine vasopressin signaling in the suprachiasmatic nucleus on the resilience of circadian clock to jet lag.

    abstract::Almost all organisms on Earth have an internal biological clock, known as the circadian clock. This clock system drives robust oscillations in metabolism, physiology, and behavior, such as hormone secretions, blood pressure, and sleep/wake cycles, with a period of approximately 24h. In mammals, circadian rhythms are g...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2017.10.007

    authors: Yamaguchi Y

    更新日期:2018-04-01 00:00:00

  • Interaction between nitric oxide and substance P on heat-induced inflammation in rat paw.

    abstract::To elucidate the interaction between nitric oxide (NO) and substance P (SP) in neurogenic inflammatory responses, we measured the change in the degree of Evans blue leakage and NO levels in perfusate from the subcutaneous space in the rat instep following noxious heat stimulation (47 degrees C for 30 min). Furthermore...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(99)00107-8

    authors: Yonehara N,Yoshimura M

    更新日期:2000-01-01 00:00:00

  • Quantitative and temporal relationship between local cerebral blood flow and neuronal activation induced by somatosensory stimulation in rats.

    abstract::In many studies on functional neuroimaging, change in local cerebral blood flow induced by sensory stimulation (evoked LCBF) is used as a marker for change in cortical neuronal activity, although a full description of the relationship between the evoked LCBF and neuronal activity has not been given. The purpose of thi...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(01)00236-x

    authors: Matsuura T,Kanno I

    更新日期:2001-07-01 00:00:00

  • Shunting versus inactivation: simulation of GABAergic inhibition in spider mechanoreceptors suggests that either is sufficient.

    abstract::Afferent neurons entering the central nervous systems of vertebrates and invertebrates receive presynaptic inhibition on their axon terminals. This usually involves an increase in membrane conductance (shunting) and depolarization (primary afferent depolarization, PAD). In arachnids and crustaceans the peripherally lo...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2006.03.002

    authors: French AS,Panek I,Torkkeli PH

    更新日期:2006-06-01 00:00:00