Abstract：
:Carbon monoxide (CO) is a gas that can permeate biological membranes and it has been suggested that the gas plays a signaling role in the brain by activating soluble guanylyl cyclase (sGC). CO is generated by heme oxygenase during the conversion of heme to biliverdin. In this study, we raised an antiserum against the chemically synthesized amino-terminal fragment of heme oxygenase-2 (HO-2) and studied the distribution of this enzyme in the rat cerebellum by an immunocytochemical method. Immunoreactivity specific for HO-2 was observed only in neurons. In the Purkinje cells and the basket cells of the cerebellum, immunoreactivity was detected in the dendrites and the somata but not in the axon terminals, suggesting that CO might be liberated primarily from the dendrites and somata rather than from the axons in this region of the rat brain.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Yamanaka M,Yamabe K,Saitoh Y,Katoh-Semba R,Semba Rdoi
10.1016/0168-0102(96)01018-8subject
Has Abstractpub_date
1996-03-01 00:00:00pages
403-7issue
4eissn
0168-0102issn
1872-8111pii
0168010296010188journal_volume
24pub_type
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