Abstract:
:Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26 h, in which a sleep-wake cycle consisting of 10-min sleep EEG recording on a bed and 20-min resting awake on a semi-upright chair were repeated. Saliva melatonin level and core body temperature was measured throughout the experiment. Bright light significantly delayed rhythms of melatonin secretion (01:58 h), core body temperature (01:12 h) and sleep propensity (02:00 h), compared as dim light session. Significant positive correlation was found between bright light-induced phase change in core body temperature and that in sleep propensity rhythm. Light-induced melatonin suppression significantly positively correlated with the phase change in core body temperature and that in sleep propensity rhythm. Assuming that light-induced melatonin suppression represents an acute impact of light on the circadian pacemaker, our results suggest that such an impact may be directly reflected in phase changes of sleep propensity and core body temperature rhythms rather than in melatonin rhythm.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Kubota T,Uchiyama M,Suzuki H,Shibui K,Kim K,Tan X,Tagaya H,Okawa M,Inoue Sdoi
10.1016/s0168-0102(01)00310-8subject
Has Abstractpub_date
2002-02-01 00:00:00pages
115-22issue
2eissn
0168-0102issn
1872-8111pii
S0168010201003108journal_volume
42pub_type
临床试验,杂志文章,随机对照试验abstract::Recent studies have shown that certain aromatic aldehydes are ligands for olfactory receptors expressed in mammalian sperm cells and induce sperm chemotaxis. Using a conditioning paradigm, the olfactory sensitivity of five CD-1 mice for seven aromatic aldehydes was investigated. With all seven stimuli, the mice discri...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2011.08.009
更新日期:2011-12-01 00:00:00
abstract::The synthesis of glial-fibrillary acidic protein (GFAP) or the re-expression of progenitor markers such as Nestin increases in reactive astrocytes after brain ischemia. We investigated the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-bindin...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.12.013
更新日期:2010-04-01 00:00:00
abstract::Recently, we have found novel mammalian tachykinins, neurokinin alpha and beta isolated from porcine spinal cord, whose chemical structures are similar to those of substance P or kassinin. In the present study, we describe a specific assay system for neurokinin alpha and beta by combining HPLC and radioimmunoassay. We...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(84)90009-9
更新日期:1984-12-01 00:00:00
abstract::Huntington's disease (HD) is an autosomal dominant inheritable neurodegenerative disorder currently without effective treatment. It is caused by an expanded polyglutamine (poly Q) tract in the corresponding protein, huntingtin (htt), and therefore suppressing the huntingtin expression in brain neurons is expected to d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.06.021
更新日期:2005-11-01 00:00:00
abstract::This experiment tested the effect of haloperidol on the sympathetic and thermogenic effects induced by orexin A. The firing rates of the sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley r...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00191-8
更新日期:2003-01-01 00:00:00
abstract::We have generated a transgenic mouse model in which astrocytes express an enhanced green fluorescent protein (EGFP) under the control of the mouse glial fibrillary acidic protein (GFAP) promoter. EGFP, which is characteristically found throughout the cell, was expressed in these animals even in astrocytic fine process...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2003.08.008
更新日期:2003-12-01 00:00:00
abstract::In previous studies we provided evidence for changes in prolactin (PRL) receptor levels in the male rat brain after continuously infusing morphine using subcutaneously implanted miniosmotic pumps. In this work we have studied the binding of PRL in the male rat brain following morphine administration by both subcutaneo...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(95)00953-1
更新日期:1995-10-01 00:00:00
abstract::We have been advocating cognitive developmental robotics to obtain new insight into the development of human cognitive functions by utilizing synthetic and constructive approaches. Among the different emotional functions, empathy is difficult to model, but essential for robots to be social agents in our society. In my...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2014.12.002
更新日期:2015-01-01 00:00:00
abstract::Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injur...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2020.05.005
更新日期:2020-05-24 00:00:00
abstract::GABAergic characteristics of transcallosal activity of cat pyramidal tract neurons (PTNs) and non-PTNs (nPTNs) were studied with stressing on GABAB receptors. PTNs and nPTNs were further classified into group 1 (< 10 ms) and group 2 (> 10 ms) based on the latency upon transcallosal stimulation. However, mainly the res...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(96)01112-1
更新日期:1996-12-01 00:00:00
abstract::Exercise appears to improve hippocampal plasticity and cognitive function, leading us to postulate that exercise may activate hippocampal neurons, which in turn increase hippocampal cerebral blood flow (Hip-CBF). Recent studies using laser-Doppler flowmetry (LDF) have shown that Hip-CBF increases with behavior and loc...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.11.005
更新日期:2006-03-01 00:00:00
abstract::The subthalamic nucleus occupies a position in the indirect pathway of basal ganglia circuit, which plays an important role in the movement regulation. Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA(A) receptors containing alpha 1 subunit. Recently, zolpidem has been rep...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.02.002
更新日期:2007-05-01 00:00:00
abstract::Growth hormone (GH) is a pleiotropic hormone that exerts important functions in the control of brain development as well as in the regulation neuronal differentiation and function, together with several behavioral and psychological effects that have been linked to its modulatory actions on brain neurotransmitters. In ...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2013.03.014
更新日期:2013-08-01 00:00:00
abstract::Action potentials, when arriving at presynaptic terminals, elicit Ca(2+) influx through voltage-gated Ca(2+) channels. Intracellular [Ca(2+)] elevation around the channels subsequently triggers synaptic vesicle exocytosis and also induces various protein reactions that regulate vesicle endocytosis and recycling to pro...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2012.02.012
更新日期:2012-05-01 00:00:00
abstract::Recently, we reported a profound depletion of cardiac sympathetic nerve fibers in Parkinson's disease (PD). This cardiac sympathetic denervation is a characteristic hallmark of PD. Cardiac sympathetic dysfunction was also observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice, a model of PD. Al...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2007.11.011
更新日期:2008-03-01 00:00:00
abstract::Recent technological progress has yielded great amounts of information about the molecular constituents of postsynaptic scaffolds in the dendritic spine. Actin filaments are major cytoskeletal elements in the dendritic spine, and they functionally interact with neurotransmitter receptors via regulatory actin-binding p...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/s0168-0102(01)00209-7
更新日期:2001-05-01 00:00:00
abstract::Transforming growth factor beta (TGF-beta) is an extracellular signaling molecule known to mediate programmed cell death (PCD) in the developing retina. In the present study, we investigated the expression profiles and activity levels of TGF-beta ligand and TGF-beta receptors (TbetaR) during the successive physiologic...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.07.002
更新日期:2006-10-01 00:00:00
abstract::Using median nerve injury and immunocytochemical methods, we examined the temporal changes in neuropeptide Y (NPY) expression in the cuneate nucleus (CN) in rats following median nerve transection. Under normal circumstances, neuropeptide Y-immunoreactive (NPY-IR) fibers was not detectable in the CN. A few NPY-IR fibe...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2003.12.003
更新日期:2004-04-01 00:00:00
abstract::Acupuncture of the sacral vertebrae has therapeutic effects in patients with overactive bladders. The mechanism of these effects, however, remains unclear. The present study, using urethane-anesthetized rats, investigated the effects of acupuncture stimulation of the sacral vertebrae on bladder activity and bladder ac...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2011.09.007
更新日期:2012-01-01 00:00:00
abstract::1-methyl-4-phenylpyridinium ion (MPP(+)), an inhibitor of mitochondrial complex I, has been widely used as a neurotoxin because it elicits a severe Parkinson's disease-like syndrome with elevation of intracellular reactive oxygen species (ROS) level and apoptotic death. Salvianic acid A (SA), isolated from the Chinese...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.10.001
更新日期:2005-02-01 00:00:00
abstract::Long-term depression at parallel fiber-Purkinje cell synapses plays a principal role in learning in the cerebellum, which acts as a supervised learning machine. Recent experiments demonstrate various forms of synaptic plasticity at different sites within the cerebellum. In this article, we take into consideration syna...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2019.03.001
更新日期:2019-11-01 00:00:00
abstract::Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.11.002
更新日期:2007-03-01 00:00:00
abstract::Many different kinds of voltage-gated ion channels (Na+ channels, K+ channels, Ca2+ channels) exist at neuronal dendrites. Integration of dendritic electric signals (excitatory postsynaptic potentials (EPSPs), inhibitory postsynaptic potentials (IPSPs) and action potentials) and/or non-electric signals (Ca2+ and secon...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/s0168-0102(00)00120-6
更新日期:2000-07-01 00:00:00
abstract::During development, neurons migrate from their origin to their final destinations where they form neuronal architectures such as layers and nuclei. While the mechanisms for the formation of laminated structures have been studied extensively, little is known about nucleogenesis. Previously, we analyzed nucleogenesis in...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2009.01.007
更新日期:2009-05-01 00:00:00
abstract::The responses of slice-cultured Purkinje cells to trans-DL-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD) were examined by intracellular recording techniques and fura-2 microfluorometry. Bath-application of t-ACPD (100 microM, 30 s), a selective agonist of metabotropic glutamate receptors (mGluRs), to Purkinje cel...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(93)90125-a
更新日期:1993-03-01 00:00:00
abstract::Acute exposure to kainic acid (KA) induces neurochemical changes in dopaminergic systems in the brain and the aim of the present study was to investigate the acute toxicity of KA upon dopamine D2 receptors. Adult rats were injected intraperitoneally with either saline or 16 mg/kg KA. Brains were removed after 4 h. Mem...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00130-2
更新日期:1998-03-01 00:00:00
abstract::To investigate the role mesostriatal dopamine system plays in pain processing, we examined the withdrawal response of rat hindpaws to mechanical stimulus at 1, 4, and 12 weeks after unilateral 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal pathway. In all of the 6-OHDA rats examined, almost no tyrosine hydroxy...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.01.005
更新日期:2005-05-01 00:00:00
abstract::Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarif...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.10.020
更新日期:2007-02-01 00:00:00
abstract::There is an endocrinological concern that environmental endocrine disrupters (EEDs) may influence sexual differentiation. Bisphenol A (BPA), one of EEDs, is released from polycarbonate plastics, and has been detected in the human umbilical cord. In this study, we examined the effect of BPA on the sexual differentiatio...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00251-1
更新日期:2003-03-01 00:00:00
abstract::GABAergic neurons in the hippocampus proper are greatly diverse in their morphological and physiological features. In the present study we examined whether or not they are also diverse regarding the density of GABAergic input on their somata. GABAergic neurons were immunocytochemically identified with antibodies again...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(96)01102-9
更新日期:1996-10-01 00:00:00