The abnormal processing of TDP-43 is not an upstream event of reduced ADAR2 activity in ALS motor neurons.

abstract：:The effects of iontophoretically applied (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), an agonist of metabotropic glutamate receptors, were examined in rat cerebellar Purkinje cells in vivo. Multibarrel electrodes were used for extracellular recordings of spontaneous single unit discharges and iontop...

journal_title：Neuroscience research

authors： Lingenhöhl K,Knöpfel T,Olpe HR

更新日期：1993-12-01 00:00:00

abstract：:Prepulse inhibition (PPI) and habituation of the acoustic startle reflex (ASR) are considered to be candidate endophenotypes of schizophrenia. However, to our knowledge, only one group has investigated these startle measures in Asian patients with schizophrenia. In the present study, we evaluated these startle measure...

journal_title：Neuroscience research

authors： Takahashi H,Iwase M,Ishii R,Ohi K,Fukumoto M,Azechi M,Ikezawa K,Kurimoto R,Canuet L,Nakahachi T,Iike N,Tagami S,Morihara T,Okochi M,Tanaka T,Kazui H,Yoshida T,Tanimukai H,Yasuda Y,Kudo T,Hashimoto R,Takeda M

更新日期：2008-11-01 00:00:00

abstract：:Recent technologies and developments in neuroscience have contributed to remarkable scientific discoveries, and have also raised many new philosophical, ethical, legal, and social issues. Research in "neuroethics" has identified various ethical issues, which will be difficult for current biomedical ethics to resolve f...

journal_title：Neuroscience research

authors： Fukushi T,Sakura O,Koizumi H

更新日期：2007-01-01 00:00:00

abstract：:The effects of substance P (SP) on cholinergic transmission were studied at the neuromuscular junction of frogs by intracellular and voltage-clamp recording methods. Bath application of SP increased the amplitude of end-plate potential (e.p.p.) evoked in either low-Ca2+ -high Mg2+ or curare-containing solution. SP at ...

journal_title：Neuroscience research

authors： Akasu T

更新日期：1986-05-01 00:00:00

abstract：:Disturbed circadian rhythmicity is associated with human diseases such as sleep and mood disorders. However, study of human endogenous circadian rhythm is laborious and time-consuming, which hampers the elucidation of diseases. It has been reported that peripheral tissues exhibit circadian rhythmicity as the suprachia...

journal_title：Neuroscience research

authors： Ebisawa T,Numazawa K,Shimada H,Izutsu H,Sasaki T,Kato N,Tokunaga K,Mori A,Honma K,Honma S,Shibata S

更新日期：2010-02-01 00:00:00

abstract：:In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the...

journal_title：Neuroscience research

authors： Ishida Y,Todaka K,Kuwahara I,Nakane H,Ishizuka Y,Nishimori T,Mitsuyama Y

更新日期：1998-04-01 00:00:00

abstract：:Electrical stimulation could enhance nerve regeneration and functional recovery. The objective of this study was to evaluate the regenerative effects of implanted electrodes with different contacts in resected sciatic nerve. Sciatic nerve resection and microsurgical repair models were established and randomly divided ...

journal_title：Neuroscience research

authors： Yu AP,Shen YJ,Qiu YQ,Li J,Shen YD,Wang XM,Cong M,He QR,Chen QZ,Jiang S

更新日期：2019-08-01 00:00:00

abstract：:How the nervous system controls the sensation and memory of information from the environment is an essential question. The nematode Caenorhabditis elegans is a useful model for elucidating neural information processing that mediates sensation and memory. The entire nervous system of C. elegans consists of only 302 neu...

journal_title：Neuroscience research

authors： Ohta A,Kuhara A

更新日期：2013-07-01 00:00:00

abstract：:Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused on its interaction with polarity-related molecules. In the present study, we identified a PDZ protein, Lin-7B, as a binding p...

journal_title：Neuroscience research

authors： Sudo K,Ito H,Iwamoto I,Morishita R,Asano T,Nagata K

更新日期：2006-12-01 00:00:00

abstract：:Damage to the central nervous system (CNS) leads to the disruption of the axonal network and causes neurological dysfunction. Recovery of neurological functions requires restoration of the axonal network; however, injured axons in the adult mammalian CNS rarely regenerate after injury. Failure of the injured axon to r...

journal_title：Neuroscience research

authors： Muramatsu R,Yamashita T

更新日期：2014-01-01 00:00:00

abstract：:L-glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system and has also been implicated as a potent neurotoxin. To ensure a high signal-to-noise ratio during synaptic transmission and to prevent neuronal damage that might occur as a result of excessive activation of glutamate recept...

journal_title：Neuroscience research

authors： Tanaka K

更新日期：2000-05-01 00:00:00

abstract：:The neurodegenerative process in Parkinson's disease (PD) is accompanied by the presence of a neuroinflammatory response, which has been suggested as one of the principal components involved in PD progression. In this report we assessed the inflammatory potential of alpha-synuclein, a protein central to PD pathogenesi...

journal_title：Neuroscience research

authors： Alvarez-Erviti L,Couch Y,Richardson J,Cooper JM,Wood MJ

更新日期：2011-04-01 00:00:00

abstract：:A glial cell line designated as B2 was generated from primary cultures of oligodendrocytes/astrocytes isolated from an adult BALB/c mouse brain and maintained for over 1 year. Phenotypic characteristics of B2 cells were investigated by immunolabeling with cell type-specific markers for oligodendrocytes (O4 and galacto...

journal_title：Neuroscience research

authors： Satoh J,Tabira T,Kim SU

更新日期：1994-08-01 00:00:00

abstract：:Forebrain heat shock protein 70 (HSP70) immunohistochemical reactivity was investigated in rats subjected to gamma knife irradiation focusing on the right caudate putamen nucleus. The forebrain sections of all experimental animals were processed with anti-HSP70 antiserum and then by avidin-biotin peroxidase complex im...

journal_title：Neuroscience research

authors： Rao ZR,Ge X,Qiou JY,Yang T,Duan L,Ju G

更新日期：2000-10-01 00:00:00

abstract：:Neuronal development is composed of the complex steps which involve many signaling proteins. On the other hand, there are many proteins highly expressed in the differentiated neurons at developmental stages, but of which physiological functions are not precisely known so far. Glycoprotein 6a (GPM6a) currently belongs ...

journal_title：Neuroscience research

authors： Ito Y,Honda A,Igarashi M

更新日期：2018-03-01 00:00:00

abstract：:During development, neurons migrate from their origin to their final destinations where they form neuronal architectures such as layers and nuclei. While the mechanisms for the formation of laminated structures have been studied extensively, little is known about nucleogenesis. Previously, we analyzed nucleogenesis in...

journal_title：Neuroscience research

authors： Watanabe H,Murakami F

更新日期：2009-05-01 00:00:00

abstract：:Neuropsin is a serine protease cloned from the mouse hippocampus. Since neuropsin is a secreted protein which effectively cleaves fibronectin, it may affect cell adhesion or cell migration by modulating the content and/or chemical characteriscs of fibronectin in extracellular matrix (ECM). In adhesion assays, alpha5B2...

journal_title：Neuroscience research

authors： Tani N,Matsumoto K,Ota I,Yoshida S,Takada Y,Shiosaka S,Matsuura N

更新日期：2001-02-01 00:00:00

abstract：:In the present study, the monoclonal antibody Alz-50 has been used to determine and compare the immunohistochemical localization of phosphorylated tau proteins in the developing and normal adult spinal cord. At all stages of fetal life Alz-50 fiber immunoreactivity was observed in the dorsal roots, in the dorsal and d...

journal_title：Neuroscience research

authors： Liberini P,Valerio A,Moretto G,Rizzonelli P,Memo M,Rizzuto N,Spano PF

更新日期：1995-05-01 00:00:00

abstract：:We suggest a time-varying partial correlation as a statistical measure of dynamic functional connectivity (dFC) in the human brain. Traditional statistical models often assume specific distributions on the measured data such as the Gaussian distribution, which prohibits their application to neuroimaging data analysis....

journal_title：Neuroscience research

authors： Lee N,Kim JM

更新日期：2020-07-03 00:00:00

abstract：:Excitatory synaptic transmission from two input systems to hippocampal CA3 pyramidal neurons was investigated by the whole-cell patch-clamp technique for thin slice preparation, with special reference to long-term potentiation (LTP) in these systems. Excitatory postsynaptic currents (EPSCs) evoked by fimbrial stimulat...

journal_title：Neuroscience research

authors： Katsuki H,Kaneko S,Tajima A,Satoh M

更新日期：1991-11-01 00:00:00

abstract：:Many different kinds of voltage-gated ion channels (Na+ channels, K+ channels, Ca2+ channels) exist at neuronal dendrites. Integration of dendritic electric signals (excitatory postsynaptic potentials (EPSPs), inhibitory postsynaptic potentials (IPSPs) and action potentials) and/or non-electric signals (Ca2+ and secon...

journal_title：Neuroscience research

authors： Takagi H

更新日期：2000-07-01 00:00:00

abstract：:Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In volta...

journal_title：Neuroscience research

authors： Koyano K,Funabiki K,Ohmori H

更新日期：1996-09-01 00:00:00

abstract：:We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the ...

journal_title：Neuroscience research

authors： Ye R,Li N,Han J,Kong X,Cao R,Rao Z,Zhao G

更新日期：2009-07-01 00:00:00

abstract：:Dynamic binding of different brain areas is critical for various cognitive functions. The thalamic reticular nucleus (TRN) is a GABAergic nucleus that constrains information flow through thalamocortical loop by providing inhibitory innervation to the thalamus. In this review, I summarize anatomical and single-cell-lev...

journal_title：Neuroscience research

authors： Takata N

更新日期：2020-07-01 00:00:00

abstract：:To elucidate biophysical mechanisms underlying the Zn2+ block on the low-threshold T-type Ca2+ current (I(T)), we examined the Zn(2+)-induced alterations of gating properties of I(T) of a rat thalamic relay neuron and of alpha1G channels expressed in HEK-293 cells, using a whole-cell voltage clamp technique. The effec...

journal_title：Neuroscience research

authors： Noh J,Kim MK,Chung JM

更新日期：2010-04-01 00:00:00

abstract：:We examined effects of carbachol (CCh), muscarinic receptor agonist, on long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) at Schaffer collateral-CA1 synapse of guinea pig hippocampal slices using extracellular recording technique. Application of 0.1 microM CCh to the slices significantly ...

journal_title：Neuroscience research

authors： Shimoshige Y,Maeda T,Kaneko S,Akaike A,Satoh M

更新日期：1997-02-01 00:00:00

abstract：:Efferent neurons to the cochlea in the guinea pig were observed in the superior olivary complex and ventral lateral lemniscal nuclei after injection of WGA-HRP into the cochlea via the round window. Of HRP-labeled nerve cells found in the brainstem, about 60% and 10% were located in the ipsilateral lateral superior ol...

journal_title：Neuroscience research

authors： Tokunaga A

更新日期：1988-10-01 00:00:00

abstract：:The alar plate of the prosencephalon differentiates into a tectum-like structure when transplanted into the mesencephalon around the 10-somite stage. Here, we report on the projection pattern of the retinal ganglion cells to the transplants. Optic nerve fibers were labeled with horseradish peroxidase (HRP) and 3H-prol...

journal_title：Neuroscience research

authors： Nakamura H,Matsui KA,Takagi S,Fujisawa H

更新日期：1991-08-01 00:00:00

abstract：:We newly developed an infrared video-oculographic system for on-line tracking of the eye position in awake and head-fixed mice, with high temporal resolution (240 Hz). The system consists of a commercially available high-speed CCD camera and an image processing software written in LabVIEW run on IBM-PC with a plug-in ...

journal_title：Neuroscience research

authors： Sakatani T,Isa T

更新日期：2004-05-01 00:00:00

abstract：:The distribution of neurofilament proteins and peripherin in the pituitary gland of the rat was studied with a panel of monoclonal and polyclonal antibodies recognizing different neurofilament subunits. In the posterior lobe, a dense plexus of neurofilament- and peripherin-immunoreactive fibers was seen. In the interm...

journal_title：Neuroscience research

authors： Bäck N,Tyynelä M,Portier MM,Virtanen I,Soinila S

更新日期：1995-06-01 00:00:00