Abstract：
:We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the protective role of GSRd to attenuate ischemic neuronal injury in vitro. Cultured hippocampal neurons were exposed to oxygen-glucose deprivation (OGD) for 2h followed by a 24-h reoxygenation. GSRd exhibited remarkable neuroprotection when presented during OGD and reoxygenation, which may be ascribed to its antioxidative properties by reducing the intracellular reactive oxygen species and malondialdehyde production; increasing glutathione content; and enhancing the antioxidant enzymatic activities of catalase, superoxide dismutase and glutathione peroxidase. Additionally, GSRd could stabilize the mitochondrial membrane potential and attenuate apoptotic death of hippocampal neurons after OGD exposure. These findings suggested that GSRd may be a potential neuroprotective agent for cerebral ischemic injury and should encourage further in vivo studies on stroke to explore the potential neuroprotective efficacy of GSRd.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Ye R,Li N,Han J,Kong X,Cao R,Rao Z,Zhao Gdoi
10.1016/j.neures.2009.03.016subject
Has Abstractpub_date
2009-07-01 00:00:00pages
306-10issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(09)00095-9journal_volume
64pub_type
杂志文章abstract：:The disposition of the facial vibrissae of the mouse is represented as a matrix-like array of cell aggregates in rows and columns at every station of the whisker-to-barrel pathway. In order to evaluate the role of each station in this pathway, lesions were made in the facial vibrissae of the mystacial group on P0-P3, ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00969-Z
更新日期：1995-11-01 00:00:00
abstract：:Increased levels of proinflammatory cytokines have been implicated in schizophrenia; however, their pathophysiological roles in abnormal brain dysfunctions remain unclear. We evaluated the effect of proinflammatory cytokines on a high-fat diet (HFD)-induced prepulse inhibition (PPI) deficits in the acoustic startle re...
journal_title：Neuroscience research
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pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00065-8
更新日期：2003-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00184-6
更新日期：2003-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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journal_title：Neuroscience research
pub_type： 杂志文章,评审
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journal_title：Neuroscience research
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journal_title：Neuroscience research
pub_type： 杂志文章
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journal_title：Neuroscience research
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