Navigation ability dependent neural activation in the human brain: an fMRI study.

Abstract:

:Visual-spatial navigation in familiar and unfamiliar environments is an essential requirement of daily life. Animal studies indicated the importance of the hippocampus for navigation. Neuroimaging studies demonstrated gender difference or strategies dependent difference of neural substrates for navigation. Using functional magnetic resonance imaging, we measured brain activity related to navigation in four groups of normal volunteers: good navigators (males and females) and poor navigators (males and females). In a whole group analysis, task related activity was noted in the hippocampus, parahippocampal gyrus, posterior cingulate cortex, precuneus, parietal association areas, and the visual association areas. In group comparisons, good navigators showed a stronger activation in the medial temporal area and precuneus than poor navigators. There was neither sex effect nor interaction effect between sex and navigation ability. The activity in the left medial temporal areas was positively correlated with task performance, whereas activity in the right parietal area was negatively correlated with task performance. Furthermore, the activity in the bilateral medial temporal areas was positively correlated with scores reflecting preferred navigation strategies, whereas activity in the bilateral superior parietal lobules was negatively correlated with them. Our data suggest that different brain activities related to navigation should reflect navigation skill and strategies.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Ohnishi T,Matsuda H,Hirakata M,Ugawa Y

doi

10.1016/j.neures.2006.04.009

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

361-9

issue

4

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(06)00093-9

journal_volume

55

pub_type

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