Up-regulation of P/Q-type voltage-gated Ca2+ channel immunoreactivity within parvalbumin positive neurons in the rat hippocampus following status epilepticus.


:To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus following status epilepticus (SE). Compared to controls, only P/Q-type (alpha1A) VGCC immunoreactivity was enhanced in PV positive neurons at the early point following SE. The alteration in P/Q-type (alpha1A) VGCC immunoreactivity showed an inverse proportionality to that in PV immunoreactivity in the dentate gyrus and the CA1 region. These findings suggest that SE may induce prolonged up-regulation in P/Q-type VGCC expression within PV positive neurons.


Neurosci Res


Neuroscience research


Kim JE,Kwak SE,Kim DS,Won MH,Choi HC,Song HK,Kim YI,Kang TC




Has Abstract


2007-03-01 00:00:00














  • Neuronal nitric oxide has a role as a perfusion regulator and a synaptic modulator in cerebellum but not in neocortex during somatosensory stimulation--an animal PET study.

    abstract::To clarify a role of neuronal nitric oxide in neurovascular coupling, we performed cerebral blood flow (CBF) and cerebral metabolic rate of glucose (CMR(glc)) measurements with positron emission tomography in somatosensory-stimulated cats using a specific neuronal nitric oxide synthase inhibitor, 7-nitroindazole (7-NI...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hayashi T,Katsumi Y,Mukai T,Inoue M,Nagahama Y,Oyanagi C,Yamauchi H,Shibasaki H,Fukuyama H

    更新日期:2002-10-01 00:00:00

  • Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines.

    abstract::Recent technological progress has yielded great amounts of information about the molecular constituents of postsynaptic scaffolds in the dendritic spine. Actin filaments are major cytoskeletal elements in the dendritic spine, and they functionally interact with neurotransmitter receptors via regulatory actin-binding p...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Shirao T,Sekino Y

    更新日期:2001-05-01 00:00:00

  • Glutamatergic neurons in the lateral periaqueductal gray innervate neurokinin-1 receptor-expressing neurons in the ventrolateral medulla of the rat.

    abstract::The neural pathways underlying the respiratory responses elicited by electrical or chemical stimulation of the lateral part of the periaqueductal gray (lPAG) remain unsettled. In the present study, we examined the lPAG projection to neurokinin-1 receptor (NK1R)-immunoreactive (ir) neurons in the ventrolateral medulla ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Oka T,Yokota S,Tsumori T,Niu JG,Yasui Y

    更新日期:2012-10-01 00:00:00

  • Acute ethanol administration transiently decreases [3H]-DAMGO binding to mu opioid receptors in the rat substantia nigra pars reticulata but not in the caudate-putamen.

    abstract::Ethanol's actions in brain have been suggested to be partially mediated by a mechanism involving the ethanol-induced activation of the endogenous opioid system. Opioid systems, which are closely linked with dopamine transmission, are thought to be affected by ethanol through alterations in the processing, release, and...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Méndez M,Leriche M,Carlos Calva J

    更新日期:2003-10-01 00:00:00

  • Sagittal organization of the olivocerebellonuclear pathway in the rat. II. Connections with the nucleus interpositus.

    abstract::The organization of the sagittal Zone C of the cerebellar cortex of the rat was studied with respect to its efferent projections and to its inferior olive (IO) afferent connections. Wheat-germ agglutinin conjugated to horseradish peroxidase was used as a tracer. Zone C has been defined as the cortical region projectin...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Buisseret-Delmas C

    更新日期:1988-08-01 00:00:00

  • Sensorial organisation favouring higher visual contribution is a risk factor of falls in an occupational setting.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Vouriot A,Gauchard GC,Chau N,Benamghar L,Lepori ML,Mur JM,Perrin PP

    更新日期:2004-03-01 00:00:00

  • DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complex.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Im JY,Lee KW,Junn E,Mouradian MM

    更新日期:2010-07-01 00:00:00

  • Impairment of active avoidance produced after destruction of pedunculopontine nucleus areas in the rat.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Fujimoto K,Yoshida M,Ikeguchi K,Niijima K

    更新日期:1989-04-01 00:00:00

  • Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic substrates.

    abstract::Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Bernstein DL,Nayak SU,Oliver CF,Rawls SM,Rom S

    更新日期:2020-06-01 00:00:00

  • Serotonin-induced nitric oxide production in the ventral nerve cord of the earthworm, Eisenia fetida.

    abstract::Effect of serotonin on nitric oxide (NO) production in the ventral nerve cord (VNC) of the earthworm Eisenia fetida was investigated by a bio-imaging and an electrochemical technique. In the bio-imaging, the spatial pattern of NO production in VNC was visualized using an NO-specific fluorescent dye, diaminofluorescein...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Kitamura Y,Naganoma Y,Horita H,Ogawa H,Oka K

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  • Carnosine: effect on aging-induced increase in brain regional monoamine oxidase-A activity.

    abstract::Aging is a natural biological process associated with several neurological disorders along with the biochemical changes in brain. Aim of the present investigation is to study the effect of carnosine (0.5-2.5μg/kg/day, i.t. for 21 consecutive days) on aging-induced changes in brain regional (cerebral cortex, hippocampu...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Banerjee S,Poddar MK

    更新日期:2015-03-01 00:00:00

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    abstract::Using immunohistochemistry and retrograde transport techniques, this study demonstrates that serotonin (5-HT) cells in the dorsal tegmental gray of the pons at rostrocaudal from P1 to P6 levels are sources of bilateral serotonergic projections to the gigantocellular tegmental field of the medial pontine and medullary ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Kobayashi Y,Matsuyama K,Mori S

    更新日期:1994-07-01 00:00:00

  • Development of artificial empathy.

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    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Asada M

    更新日期:2015-01-01 00:00:00

  • The membrane protein A5, a putative neuronal recognition molecule, promotes neurite outgrowth.

    abstract::The A5 is an unique membrane protein that is expressed in the neurons of the visual system and general somatic sensory system of Xenopus laevis. We cultured retinal explants or trigeminal ganglion neurons on the monolayers of A5-expressing line cells obtained by transfection with the cDNA, and found that the A5-expres...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Hirata T,Takagi S,Fujisawa H

    更新日期:1993-07-01 00:00:00

  • Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2).

    abstract::Huntington's disease (HD) is caused due to expansion of CAG repeats in the gene huntingtin (Htt). Adaptor protein Grb2, involved in Ras-MAP kinase pathway, is a known interactor of Htt. Mutant Htt-Grb2 interaction reduces Ras-MAPK signaling in HD models. In normal cells Grb2 forms Grb2-Sos1-Gab1 complex through its N-...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Baksi S,Basu S,Mukhopadhyay D

    更新日期:2014-10-01 00:00:00

  • Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.

    abstract::While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synth...

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    pub_type: 临床试验,杂志文章


    authors: Watanabe A,Kato N,Kato T

    更新日期:2002-04-01 00:00:00

  • Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers.

    abstract::In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the...

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  • Coevolution of cytokine receptor families in the immune and nervous systems.

    abstract::Close relationships between the nervous system and immune systems at molecular levels have now become evident. Receptors for CDF/LIF and CNTF, i.e., factors which play important roles in the nervous system, share a close structural similarity to those for IL-6, which is a molecule acting in the immune system. Receptor...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


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    abstract::In this review, we describe recent experimental observations and model simulations in the research subject of brain-machine interface (BMI). Studies of BMIs have applied decoding models to extract functional characteristics of the recorded neurons, and some of these have more focused on adaptation based on neural oper...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Ito H,Fujiki S,Mori Y,Kansaku K

    更新日期:2020-07-01 00:00:00

  • Migration and differentiation of neural cell lines transplanted into mouse brains.

    abstract::In the past few years, the plasticity of the regional specification of the CNS has been widely debated on the results from in utero transplantation. Two different results are reported with this transplantation method. One is that the distribution of transplanted cells is dependent on the donor origin, and the other is...

    journal_title:Neuroscience research

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  • Nerve growth factor-like activity in the rat pituitary intermediate lobe.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Soinila S,Lakshmanan J,Lahtinen T

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  • Influence of tooth-loss and concomitant masticatory alterations on cholinergic neurons in rats: immunohistochemical and biochemical studies.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Terasawa H,Hirai T,Ninomiya T,Ikeda Y,Ishijima T,Yajima T,Hamaue N,Nagase Y,Kang Y,Minami M

    更新日期:2002-08-01 00:00:00

  • Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1.

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    authors: Jaaro-Peled H,Altimus C,LeGates T,Cash-Padgett T,Zoubovsky S,Hikida T,Ishizuka K,Hattar S,Mongrain V,Sawa A

    更新日期:2016-11-01 00:00:00

  • Shank3 contributes to neuropathic pain by facilitating the SNI-dependent increase of HCN2 and the expression of PSD95.

    abstract::Neuropathic pain is a very complex chronic pain state, the detailed molecular mechanisms of which remain unclear. In the present study, Shank3 was found to play an important role in neuropathic pain in rats following spared nerve injury (SNI). Shank3 was upregulated in the spinal dorsal horn of rats subjected to SNI, ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Zhang X,Li X,Wang H,Xie X,Li Y,Xu X,Su S,Zhao H,Li J,Ke C,Liu J

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Wang XJ,Xu JX

    更新日期:2005-02-01 00:00:00

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Meng P,Yoshida H,Tanji K,Matsumiya T,Xing F,Hayakari R,Wang L,Tsuruga K,Tanaka H,Mimura J,Kosaka K,Itoh K,Takahashi I,Kawaguchi S,Imaizumi T

    更新日期:2015-05-01 00:00:00

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Süer C,Dolu N,Artis AS,Sahin L,Yilmaz A,Cetin A

    更新日期:2011-05-01 00:00:00

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Steffens H,Hoheisel U,Eek B,Mense S

    更新日期:2001-04-01 00:00:00

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Singh S,Kumar P

    更新日期:2018-08-01 00:00:00

  • Involvement of Gq/11 in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation.

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    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Morishita R,Ueda H,Ito H,Takasaki J,Nagata K,Asano T

    更新日期:2007-10-01 00:00:00