Abstract:
:To identify the roles of VGCC subtypes in damages/impairs of inhibitory transmission during epileptogenesis, we investigated temporal- and spatial-specific alterations in voltage-gated Ca(2+) channel (VGCC) immunoreactivities within parvalbumin (PV, a Ca(2+) binding protein) positive neurons in the rat hippocampus following status epilepticus (SE). Compared to controls, only P/Q-type (alpha1A) VGCC immunoreactivity was enhanced in PV positive neurons at the early point following SE. The alteration in P/Q-type (alpha1A) VGCC immunoreactivity showed an inverse proportionality to that in PV immunoreactivity in the dentate gyrus and the CA1 region. These findings suggest that SE may induce prolonged up-regulation in P/Q-type VGCC expression within PV positive neurons.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Kim JE,Kwak SE,Kim DS,Won MH,Choi HC,Song HK,Kim YI,Kang TCdoi
10.1016/j.neures.2006.11.007subject
Has Abstractpub_date
2007-03-01 00:00:00pages
379-86issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(06)00312-9journal_volume
57pub_type
杂志文章abstract::Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2017.02.004
更新日期:2017-07-01 00:00:00
abstract::We carried out voltage-sensitive dye imaging of the guinea pig auditory cortex to determine whether the ongoing and spontaneous activities of the cortex exhibit spatial coherence reflecting the tonotopic organization of the cortex. We used independent component analysis and a signal-plus-noise model to extract ongoing...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.01.007
更新日期:2008-05-01 00:00:00
abstract::In lightly alpha-chloralose anaesthetized cats, activity was recorded simultaneously from 2-4 primary muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles. Increased tension in medial or lateral collateral ligament was found to evoke changes in the responses of the primary spi...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90066-8
更新日期:1991-06-01 00:00:00
abstract::The lateral olfactory tract (LOT) is a central olfactory pathway, and efferent projections from the olfactory bulb are conveyed to the olfactory-related cortical structures via the LOT. The purpose of the present study is to determine the exact site of the LOT causing functional impairment in animals. After ablation o...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2012.02.006
更新日期:2012-05-01 00:00:00
abstract::Microglial activation and proliferation occur in nearly all forms of brain injury. The aim of this study was to investigate the influence of glial cell-line derived neurotrophic factor (GDNF) on proliferation and/or survival in a GMIR1 rat microglial cell line, which proliferates in response to granulocyte-macrophage-...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00036-6
更新日期:2002-07-01 00:00:00
abstract::Swelling of brain cells is one of the physiological responses associated with neuronal activation. To investigate underlying mechanisms, we analyzed interactions between changes in cell volume and synaptic responses in the hippocampal slices from rodents. Swelling within the CA1 area was detected as increases in trans...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(02)00153-0
更新日期:2002-11-01 00:00:00
abstract::In anesthetized and immobilized Japanese monkeys (Macaca fuscata), intraretinal conduction velocities of the ganglion cell axons were measured. The field potentials elicited by optic chiasm shocks consisted of fast and slow components with estimated conduction velocities of 1.19 and 0.72 m/s in recordings from the opt...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(88)90006-5
更新日期:1988-10-01 00:00:00
abstract::Diazepam binding inhibitor (DBI), a putative endogenous polypeptide ligand for benzodiazepine (BZD) receptors, has been shown to act as an inverse BZD receptor agonist in the brain. We previously suggested that the social isolation stress-induced decrease in pentobarbital sleeping time in mice was partly due to an inc...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(99)00010-3
更新日期:1999-03-01 00:00:00
abstract::In the guinea-pig two subcortical structures have been shown to contain representations of auditory space, the deep layers of the superior colliculus (SC) and the external nucleus of the inferior colliculus (ICX). The following investigation was undertaken to determine if the ICX influences the development of the SC a...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(96)01060-7
更新日期:1996-07-01 00:00:00
abstract::It has previously been shown that when a target is moved, cats can change the direction of ongoing target-reaching with brief latency suggesting a tectal relay. Switching of target-reaching has now been investigated after spinal lesions: (1) dorsally in C5 interrupting cortico- (CS) and rubrospinal (RS) fibres to fore...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(87)90023-x
更新日期:1987-10-01 00:00:00
abstract::The neural and molecular mechanisms underlying food preference have been poorly understood. We previously showed that Bifidobacterium infantis (B. infantis), a well-known probiotic bacterium, extends the lifespan of Caenorhabditis elegans (C. elegans) compared with a standard food, Escherichia coli (E. coli) OP50. In ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2019.01.011
更新日期:2020-01-01 00:00:00
abstract::NMDA receptors play an important functional role in the neuron excitability and plasticity. The conditions and consequences of their activation are of interest for many neuroscientists. This investigation was designed to explore an activation of the NMDA receptors of frog tectal neurons in vivo by a burst of spikes of...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.12.014
更新日期:2006-04-01 00:00:00
abstract::Mature rat spinal cord cDNA libraries constructed in lambda gt10 and lambda ZAPII were screened with an oligonucleotide probe (39 mer), and 4 clones that possess DNA-inserts encoding a glycine receptor subunit were obtained. The cloned cDNAs were used to reconstruct the nucleotide sequence of the full-length open read...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(91)90064-6
更新日期:1991-06-01 00:00:00
abstract::Whole-cell recordings were performed to examine the morphological properties of electrophysiologically classified area postrema (AP) neurons in rat brain slices. Using electrophysiological criteria, AP neurons were subdivided into three groups: (1) cells displaying both the hyperpolarization-activated cation current (...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2005.10.005
更新日期:2006-01-01 00:00:00
abstract::Dopamine is a major neurotransmitter in the carotid body of several animal species and its functional role at the level of peripheral arterial chemoreflex pathway is attributed to the presence of the dopamine D2-receptors. We present evidence that the dopamine D1-receptor mRNA is also expressed in the carotid body of ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(98)00033-9
更新日期:1998-06-01 00:00:00
abstract::The pattern of distribution of cholinergic fibers was examined immunohistochemically in the cat superior colliculus by using a monoclonal antibody against choline acetyltransferase (ChAT). In the superficial layers, an obvious immunoreactive zone was found in the rostral two-thirds of the outer portion of the superfic...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(89)90004-7
更新日期:1989-06-01 00:00:00
abstract::Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the e...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00065-8
更新日期:2003-07-01 00:00:00
abstract::Amphibian metamorphosis is characterized by rapid tissue remodeling and drastic changes in the body structure and function. Like other organs, olfactory system also undergoes a dramatic rearrangement as the animal experiences transition from aquatic to terrestrial habitat. Reactive oxygen species (ROS) are known to pl...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2011.11.005
更新日期:2012-02-01 00:00:00
abstract::Amyloid-beta (Aβ) peptides, Aβ 1-42 (Aβ42) and Aβ43 in particular, cause neurotoxicity and cell death in the brain of Alzheimer's disease (AD) at higher concentrations. Carnosic acid (CA), a phenolic diterpene compound in the labiate herbs rosemary and sage, serves as an activator for neuroprotective and neurotrophic ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2014.12.003
更新日期:2015-05-01 00:00:00
abstract::Dopaminergic neurons of the substantia nigra pars compacta play a major role in goal-directed behavior and reinforcement learning. The study of their local interactions has revealed that they are connected by electrical synapses. Connexins, the molecular substrate of electrical synapses, constitute a multigenic family...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.08.013
更新日期:2006-12-01 00:00:00
abstract::Considerable evidence suggests that an N-methyl-D-aspartate (NMDA) receptor plays a crucial role in memory and cognitive function. To identify the role of this receptor in higher functions of the brain, we delivered antisense oligonucleotides against an NMDA-NR1 subunit (NR1) to the hippocampus in rats using the HVJ-l...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(03)00012-9
更新日期:2003-04-01 00:00:00
abstract::Recently the authors showed that a computational model of visual saliency could account for changes in gaze behavior of monkeys with damage in the primary visual cortex. Here we propose a neural prosthesis to restore eye gaze behavior by electrically stimulating the superior colliculus to drive visual attention. The s...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2013.07.007
更新日期:2014-01-01 00:00:00
abstract::We studied the patterns of membrane potential changes in vocal cord tensor motoneurons, i.e. cricothyroid muscle motoneurons (CTMs), during fictive breathing, vocalization, coughing, and swallowing in decerebrate paralyzed cats to determine the nature of central drives to CTMs during these behaviors. CTMs were identif...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.03.009
更新日期:2004-07-01 00:00:00
abstract::We examined the effects of the odors from mother's milk, other mother's milk and formula milk on pain responses in newborns undergoing routine heelsticks. Forty-eight healthy infants were assigned to four groups, an own mother's breast milk odor group (Own MM), another mother's breast milk odor group (Other MM), a for...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2008.10.007
更新日期:2009-01-01 00:00:00
abstract::The present study was performed to determine whether the voltage gated Cl- channel (CLC) expression is altered in the hippocampus of seizure sensitive (SS) gerbils, and to identify the strong fast paired-pulse inhibition in the dentate gyrus of SS gerbils is associated with altered CLC expression. In the hippocampal p...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2004.09.010
更新日期:2005-01-01 00:00:00
abstract::Cats were trained to reach to an illuminated tube placed horizontally at shoulder level and retrieve food with the forepaw. The trajectory of an infrared light emitting diode, taped to the wrist dorsum, was recorded with a SELSPOT-like recording system. Movement paths and velocity profiles were compared before and aft...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00093-x
更新日期:1997-11-01 00:00:00
abstract::Different tracer substances were injected into the superior colliculus (CoS) in order to study its afferents and efferents with the meso-rhombencephalic tegmentum, the precerebellar nuclei and the cerebellum in the Madagascan hedgehog tenrec. The overall pattern of tectal connectivity in tenrec was similar to that in ...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/s0168-0102(97)00034-5
更新日期:1997-06-01 00:00:00
abstract::The older neurocentric view of the central nervous system (CNS) has changed radically with the growing understanding of the many essential functions of astrocytes. Advances in our understanding of astrocytes include new observations about their structure, organization, function and supportive actions to other cells. A...
journal_title:Neuroscience research
pub_type: 杂志文章,评审
doi:10.1016/j.neures.2011.06.004
更新日期:2011-10-01 00:00:00
abstract::We studied the ascending and descending axonal trajectories of excitatory vestibular neurons related to the anterior semicircular canal, by means of local stimulation and spike-triggered signal averaging techniques in anesthetized cats. More than 200 vestibular neurons related to the ampullary nerve of the anterior se...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/0168-0102(84)90036-1
更新日期:1984-10-01 00:00:00
abstract::A disynaptic projection from the spinal cord to the striatum was observed in the rat light and electron microscopically. An anterograde tracer, wheat germ agglutinin conjugated to horseradish peroxidase was injected into the ventral gray matter of the upper cervical spinal cord, and a retrograde tracer, biotinylated d...
journal_title:Neuroscience research
pub_type: 杂志文章
doi:10.1016/j.neures.2006.05.009
更新日期:2006-09-01 00:00:00