Neuronal nitric oxide has a role as a perfusion regulator and a synaptic modulator in cerebellum but not in neocortex during somatosensory stimulation--an animal PET study.

Abstract:

:To clarify a role of neuronal nitric oxide in neurovascular coupling, we performed cerebral blood flow (CBF) and cerebral metabolic rate of glucose (CMR(glc)) measurements with positron emission tomography in somatosensory-stimulated cats using a specific neuronal nitric oxide synthase inhibitor, 7-nitroindazole (7-NI). The effect on flow-metabolism coupling were tested by global and regional-specific changes on CBF and CMR(glc), and the regional-specific effect was estimated both by regions of interest (ROI) and voxel-based (VB) analysis using globally-normalized CBF and CMR(glc) changes. The electrical somatosensory stimulation in the unilateral forepaw elicited coupled increase in CBF and CMR(glc) in the contralateral somatosensory cortex (7%) and the ipsilateral cerebellum (8%). 7-NI induced 20% decrease in global CBF both during rest and activation, but not in global CMR(glc) at simulation. Both ROI and VB analysis showed that 7-NI induced an increase in CMR(glc) (13%) in the ipsilateral cerebellum compared to control under vehicle alone, but it was accompanied by only 8% increase in CBF, suggesting uncoupling of flow-metabolism while it induced any perturbations in the contralateral somatosensory cortex. These observations suggest that neuronal nitric oxide has an important role for a mediator of regional neurovascular coupling as well as synaptic modulator in the cerebellum, but less so in the neocortex.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Hayashi T,Katsumi Y,Mukai T,Inoue M,Nagahama Y,Oyanagi C,Yamauchi H,Shibasaki H,Fukuyama H

doi

10.1016/s0168-0102(02)00122-0

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

155-65

issue

2

eissn

0168-0102

issn

1872-8111

pii

S0168010202001220

journal_volume

44

pub_type

杂志文章
  • Identification of Bombyx mori 14-3-3 orthologs and the interactor Hsp60.

    abstract::The 14-3-3 protein family consists of evolutionarily conserved, acidic 30 kDa proteins composed of seven isoforms named beta, gamma, epsilon, zeta, eta, theta, and sigma in mammalian cells. The dimeric complex of 14-3-3 isoforms, acting as a molecular adaptor, plays a central role in regulation of neuronal function. S...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2008.03.007

    authors: Tabunoki H,Shimada T,Banno Y,Sato R,Kajiwara H,Mita K,Satoh J

    更新日期:2008-07-01 00:00:00

  • Sensorial organisation favouring higher visual contribution is a risk factor of falls in an occupational setting.

    abstract::The contribution of intrinsic balance control factors to fall mechanisms has received little investigation in studies on occupational accidents. The aim of this study was to assess whether postural regulation in falling workers might have specificities in terms of sensorimotor strategies and neuromuscular responses to...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2003.11.001

    authors: Vouriot A,Gauchard GC,Chau N,Benamghar L,Lepori ML,Mur JM,Perrin PP

    更新日期:2004-03-01 00:00:00

  • Concept and molecular basis of axonal regeneration after central nervous system injury.

    abstract::Damage to the central nervous system (CNS) leads to the disruption of the axonal network and causes neurological dysfunction. Recovery of neurological functions requires restoration of the axonal network; however, injured axons in the adult mammalian CNS rarely regenerate after injury. Failure of the injured axon to r...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2013.07.002

    authors: Muramatsu R,Yamashita T

    更新日期:2014-01-01 00:00:00

  • Dense GABAergic input on somata of parvalbumin-immunoreactive GABAergic neurons in the hippocampus of the mouse.

    abstract::GABAergic neurons in the hippocampus proper are greatly diverse in their morphological and physiological features. In the present study we examined whether or not they are also diverse regarding the density of GABAergic input on their somata. GABAergic neurons were immunocytochemically identified with antibodies again...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(96)01102-9

    authors: Fukuda T,Aika Y,Heizmann CW,Kosaka T

    更新日期:1996-10-01 00:00:00

  • Voltage-gated ionic currents and their roles in timing coding in auditory neurons of the nucleus magnocellularis of the chick.

    abstract::Avian cochlear neurons of the nucleus magnocellularis (NMC) are known to encode temporal information of sound. The neuron generated only a single action potential at a stable timing even though suprathreshold currents of long duration (> 100 ms) was injected. The threshold for the action potential was -42 mV. In volta...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(96)01071-1

    authors: Koyano K,Funabiki K,Ohmori H

    更新日期:1996-09-01 00:00:00

  • Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells.

    abstract::The interaction of neurotransmitter receptors with the underlying cytoskeleton via subsynaptic proteins is an important mechanism for the targeting of the receptors to synapses in the central nervous system. We show that delta glutamate receptors (delta receptors), expressed predominantly in the dendritic spines of ce...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(99)00061-9

    authors: Hirai H,Matsuda S

    更新日期:1999-09-01 00:00:00

  • Two groups of secondary vestibular neurons mediating horizontal canal signals, probably to the ipsilateral medial rectus muscle, under inhibitory influences from the cerebellar flocculus in rabbits.

    abstract::Vestibular nuclear neurons that mediate horizontal canal signals to the ipsilateral medial rectus motoneurons were explored in anesthetized and decerebrate rabbits. These neurons were identified by four criteria: (1) they were activated monosynaptically by ipsilateral vestibular nerve stimulation and (2) antidromicall...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(85)90016-1

    authors: Kawaguchi Y

    更新日期:1985-08-01 00:00:00

  • Interaction between nitric oxide and substance P on heat-induced inflammation in rat paw.

    abstract::To elucidate the interaction between nitric oxide (NO) and substance P (SP) in neurogenic inflammatory responses, we measured the change in the degree of Evans blue leakage and NO levels in perfusate from the subcutaneous space in the rat instep following noxious heat stimulation (47 degrees C for 30 min). Furthermore...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(99)00107-8

    authors: Yonehara N,Yoshimura M

    更新日期:2000-01-01 00:00:00

  • Mifepristone reduces hypothalamo-pituitary-adrenal axis activation and restores weight loss in rats subjected to dietary restriction and methylphenidate administration.

    abstract::This study evaluates the efficacy of mifepristone on weight restoration in rats subjected to dietary restriction and methylphenidate administration. 25 female rats aged between 9 and 12 months were divided into 2 groups: 5 controls (exposed only to dietary restriction) and 20 rats that were administered 5 mg/kg/d of m...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2017.12.008

    authors: Bou Khalil R,Smayra V,Saliba Y,Hajal J,Bakhos JJ,Souaiby L,Richa S,Tamraz J,Farès N

    更新日期:2018-10-01 00:00:00

  • Effects of fibronectin cleaved by neuropsin on cell adhesion and migration.

    abstract::Neuropsin is a serine protease cloned from the mouse hippocampus. Since neuropsin is a secreted protein which effectively cleaves fibronectin, it may affect cell adhesion or cell migration by modulating the content and/or chemical characteriscs of fibronectin in extracellular matrix (ECM). In adhesion assays, alpha5B2...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(00)00213-3

    authors: Tani N,Matsumoto K,Ota I,Yoshida S,Takada Y,Shiosaka S,Matsuura N

    更新日期:2001-02-01 00:00:00

  • The magnitude of long-term potentiation of field potentials induced monosynaptically in region CA3 of guinea pig hippocampus.

    abstract::The magnitude of long-term potentiation (LTP) was re-examined for monosynaptic transmission between mossy fibers and CA3 neurons in thin sections of the hippocampus of the guinea pig. Although an initial negative deflection in the field potential showed apparent short-term potentiation, this deflection was concluded t...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(86)90060-x

    authors: Higashima M,Yamamoto C

    更新日期:1986-09-01 00:00:00

  • Proline repeats, in cis- and trans-positions, confer protection against the toxicity of misfolded proteins in a mammalian cellular model.

    abstract::A broad range of neurodegenerative disorders result from the cytotoxicity conferred by aberrantly folded mutant proteins. Intriguingly, the cytotoxicity and aggregation property of a few mutant proteins are known to be modulated by the flanking sequences. One of such modulators is the proline repeat tract. Using a mam...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2011.05.001

    authors: Siwach P,Sengupta S,Parihar R,Ganesh S

    更新日期:2011-08-01 00:00:00

  • Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity.

    abstract::The current study evidenced hypothesis that mitochondrial dysfunction-oxidative stress-dependent apoptotic pathways play a critical role in degeneration of dopaminergic neurons in Parkinson's disease. Model of rotenone-induced parkinsonism in rats produced decrease in striatal complex I activity and reduced glutathion...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2011.08.008

    authors: Abdin AA,Sarhan NI

    更新日期:2011-12-01 00:00:00

  • [3H]glutamate binding sites in the rat pituitary.

    abstract::A significant activity of [3H]glutamate binding was detected in homogenate particulate preparations obtained from the rat pituitary, in addition to central structures including the cerebral cortex. In contrast to the cerebral binding, the pituitary binding was significantly inhibited by Na+ ions. It was also found tha...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(86)90034-9

    authors: Yoneda Y,Ogita K

    更新日期:1986-07-01 00:00:00

  • Dynamic control of neural stem cells by bHLH factors.

    abstract::During brain development, neural stem cells change their competency to give sequential rise to neurons and glial cells. Expression of the basic helix-loop-helix (bHLH)-type cell-fate determination factors Ascl1, Olig2, and Hes1 is oscillatory in neural stem cells. Conversely, sustained expression of these factors medi...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1016/j.neures.2018.09.005

    authors: Kageyama R,Shimojo H,Ohtsuka T

    更新日期:2019-01-01 00:00:00

  • Face representation in the human primary somatosensory cortex.

    abstract::To investigate the representation of facial skin areas in the primary somatosensory cortex (SI), we recorded magnetic fields evoked by air pressure-induced tactile stimulation applied to six points on the face, lower lip and thumb. The thumb area in the SI was located more medial and superior to the lip area, which wa...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2004.07.004

    authors: Nguyen BT,Tran TD,Hoshiyama M,Inui K,Kakigi R

    更新日期:2004-10-01 00:00:00

  • Augmentation of GABA-induced chloride current in frog sensory neurons by diazepam.

    abstract::The effect of diazepam (DZP) on the GABA-induced macroscopic and microscopic Cl- current was investigated in isolated frog sensory neurons using both 'concentration-clamp' and patch-clamp techniques. At concentration range between 10(-9) and 10(-4) M, DZP itself evoked no response but potentiated time- and dose-depend...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(89)90023-0

    authors: Yakushiji T,Tokutomi N,Akaike N

    更新日期:1989-04-01 00:00:00

  • Effect of spinal cord lesions on forelimb target-reaching and on visually guided switching of target-reaching in the cat.

    abstract::Cats were trained to reach to an illuminated tube placed horizontally at shoulder level and retrieve food with the forepaw. The trajectory of an infrared light emitting diode, taped to the wrist dorsum, was recorded with a SELSPOT-like recording system. Movement paths and velocity profiles were compared before and aft...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)00093-x

    authors: Pettersson LG,Lundberg A,Alstermark B,Isa T,Tantisira B

    更新日期:1997-11-01 00:00:00

  • DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway.

    abstract::Disrupted-in-Schizophrenia 1 (DISC1) is a susceptibility gene for major mental illnesses, including bipolar disorder and schizophrenia. Although the roles of DISC1 in nervous system development and functions are increasingly recognized, pathophysiological mechanisms underlying a range of neuropsychiatric symptoms caus...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2011.05.014

    authors: Flores R 3rd,Hirota Y,Armstrong B,Sawa A,Tomoda T

    更新日期:2011-09-01 00:00:00

  • Projection of the retinal ganglion cells to the tectum differentiated from the prosencephalon.

    abstract::The alar plate of the prosencephalon differentiates into a tectum-like structure when transplanted into the mesencephalon around the 10-somite stage. Here, we report on the projection pattern of the retinal ganglion cells to the transplants. Optic nerve fibers were labeled with horseradish peroxidase (HRP) and 3H-prol...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(91)90042-w

    authors: Nakamura H,Matsui KA,Takagi S,Fujisawa H

    更新日期:1991-08-01 00:00:00

  • The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.

    abstract::Mutations in the dynamin family GTPase OPA1 are reportedly the cause of autosomal dominant optic atrophy, the most frequently occurring form of hereditary optic neuropathy. But although the involvement of structural abnormalities of the enzyme in this neurodegenerative disease is clear, little is known about the cell ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2006.02.010

    authors: Misaka T,Murate M,Fujimoto K,Kubo Y

    更新日期:2006-06-01 00:00:00

  • Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers.

    abstract::In rats with a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion in the nigrostriatal fibers, methamphetamine (3 mg/kg, i.p.) induced Fos-like immunoreactivity (FLI), which was inhibited by pretreatment with N-methyl-D-aspartate antagonist MK-801 (1 mg/kg, i.p.), not only in the medial striatum contralateral to the...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(98)00015-7

    authors: Ishida Y,Todaka K,Kuwahara I,Nakane H,Ishizuka Y,Nishimori T,Mitsuyama Y

    更新日期:1998-04-01 00:00:00

  • Nandrolone improve synaptic plasticity at the hippocampus CA1 area and spatial localization in the Morris water maze of male adolescent rats.

    abstract::Nandrolone is the most popular compound that are mainly abused. Experimental studies have reported that administration of nandrolone affects cognitive performance. So, the aim of this study is to evaluate the effect of nandrolone on spatial localization and synaptic plasticity of male adolescent rats. Experimantal gro...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2019.09.001

    authors: Salimi Z,Khajehpour L,Moradpour F,Moazedi AA,Pourmotabbed A,Zarei F

    更新日期:2020-09-01 00:00:00

  • Neuroanatomical and neurochemical organization of projections from the central amygdaloid nucleus to the nucleus retroambiguus via the periaqueductal gray in the rat.

    abstract::The periaqueductal gray (PAG)-nucleus retroambiguus (NRA) pathway has been known to be involved in the control of vocalization and sexual behavior. To know how the amygdaloid complex influences the PAG-NRA pathway, here we first examined the synaptic organization between the central amygdaloid nucleus (CeA) fibers and...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2008.10.004

    authors: Oka T,Tsumori T,Yokota S,Yasui Y

    更新日期:2008-12-01 00:00:00

  • Ca2+ -activated K+ current at presynaptic terminals of goldfish retinal bipolar cells.

    abstract::Properties of the Ca2+ -activated K+ current (I[K(Ca)]) were investigated in bipolar cells isolated from the goldfish retina. Pharmacological experiments and single channel current recordings demonstrated that I[K(Ca)] represented currents through BK channels, which were confined mostly to the presynaptic terminal. Th...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(97)01155-3

    authors: Sakaba T,Ishikane H,Tachibana M

    更新日期:1997-03-01 00:00:00

  • Phasic nicotinic potentiation of frog retinotectal transmission enhances intrinsic activity of tectum column.

    abstract::It is well established that cholinergic modulation of functioning of neuronal networks is common in the central nervous system at all scales from neuronal columns to large nuclei. It is involved in various attentional, cognitive and behavioral performances. We have recently demonstrated that a frog retinotectal transm...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/j.neures.2012.07.002

    authors: Baginskas A,Kuraite V,Kuras A

    更新日期:2012-09-01 00:00:00

  • Anisotropic functional connections between the auditory cortex and area 18a in rat cerebral slices.

    abstract::We developed a new method to visualize the myeloarchitecture in fresh slices, and investigated the properties of the functional neural connections around the boundary between the primary auditory cortex (area 41) and area 18a in rat cerebral slices. A fresh slice illuminated by near-vertical light was observed with a ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(03)00059-2

    authors: Hishida R,Hoshino K,Kudoh M,Norita M,Shibuki K

    更新日期:2003-06-01 00:00:00

  • Nitric oxide, 2-amino-4-phosphonobutyric acid and light/dark adaptation modulate short-wavelength-sensitive synaptic transmission to retinal horizontal cells.

    abstract::Light-induced changes in the input resistance (Rin) of external, luminosity (i.e. H1) type horizontal cell (HC) perikarya were studied by the bridge-balance method in light-adapted and dark-adapted retinae of carp. Changes in input resistance (delta Rin) induced by short-(460 nm) and long-wavelength (674 nm) flashes, ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(96)01133-9

    authors: Furukawa T,Yamada M,Petruv R,Djamgoz MB,Yasui S

    更新日期:1997-01-01 00:00:00

  • NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cells.

    abstract::POZ/BTB proteins influence cellular development and in some examples act as oncoproteins. However, several POZ/BTB transcription factors have been found in terminally differentiated neurons, where their functions remain unknown. One example is NAC1, a constitutively-expressed protein that can regulate behaviors associ...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/s0168-0102(03)00024-5

    authors: Korutla L,Neustadter JH,Fournier KM,Mackler SA

    更新日期:2003-05-01 00:00:00

  • Inhibitory influence via 5-HT3 receptors on the induction of LTP in mossy fiber-CA3 system of guinea-pig hippocampal slices.

    abstract::The effects of 5-HT3-receptor-related agents on long-term potentiation (LTP) in the mossy fiber-CA3 system were studied in guinea pig hippocampal slices. 5-HT3 receptor agonists, 1-(m-chlorophenyl)-biguanide (mCPBG) and 2-methyl serotonin (2-Me-5-HT) significantly attenuated the magnitude of LTP of the population spik...

    journal_title:Neuroscience research

    pub_type: 杂志文章

    doi:10.1016/0168-0102(94)90163-5

    authors: Maeda T,Kaneko S,Satoh M

    更新日期:1994-01-01 00:00:00