Abstract：
:In order to investigate the role of the dorsal raphe nucleus and the serotonergic system in the regulation of ovulation, the number of ova and plasma luteinizing hormone (LH) concentrations were measured in female rats after making lesions in this nucleus (DRL) and/or treatment with 5-hydroxytryptamine (5-HT) receptor agonists or antagonists. DRL or sham lesion was made on the afternoon of proestrous (12:00-14:00 h) under ether anesthesia and the number of ova in the oviduct was counted on the next estrous and diestrous morning. In some animals, blood samples were taken via the atrial cannula during the proestrous evening for the radioimmunoassay of LH. All intact control and sham-operated females ovulated and plasma LH increased between 19:00 and 21:00 h. In contrast, ovulation was seen in only 36% of DRL rats. LH surge did not occur in this group. However, 80% of DRL rats ovulated after treatment with (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride [(+/-)-DOI; a 5-HT 2A/2C receptor agonist] at 15:00 h on proestrous day. LH surge was also observed in the DRL rats with (+/-)-DOI. On the other hand, only 8% of DRL rats ovulated after treatment with buspirone (5-HT 1A receptor agonist). Furthermore, when mianserin (5-HT 2A/2C receptor antagonist) was administered at 16:00 h on proestrous day, ovulation was not seen in all rats without DRL. These results suggest that the dorsal raphe nucleus plays an important role in induction of LH surge and ovulation and the 5-HT 2A/2C receptor system is involved in this mechanism.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Maekawa F,Tsukahara S,Tsukamura H,Maeda KI,Yamanouchi Kdoi
10.1016/s0168-0102(99)00090-5subject
Has Abstractpub_date
1999-12-30 00:00:00pages
291-8issue
4eissn
0168-0102issn
1872-8111pii
S0168010299000905journal_volume
35pub_type
杂志文章abstract：:This work was aimed to assess whether voluntary exercise rescued behavioral and hippocampal alterations in mice lacking the lysophosphatidic acid LPA1 receptor (LPA1-null mice), studying the potential relationship between the amount of exercise performed and its effects. Normal and LPA1-null mice underwent 23 days of ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2013.09.004
更新日期：2013-11-01 00:00:00
abstract：:In identified B6 neurons of Aplysia buccal ganglia under voltage-clamp, application of quisqualic acid (QA) induces a unique slow K(+)-current response independent of G-protein. The response was augmented by raising the temperature in a similar fashion to the Phe-Met-Arg-Phe-NH(2)-induced K(+)-current response mediate...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.09.007
更新日期：2008-01-01 00:00:00
abstract：:Using standard intracellular recording techniques 38 nonpyramidal cells or interneurons have been sampled in hippocampal slices of the rat. Among 38 physiologically identified interneurons, all 27 cells labeled with biocytin were morphologically demonstrated to be nonpyramidal and nongranule cells. The vast majority o...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90013-2
更新日期：1994-02-01 00:00:00
abstract：:DJ-1 is a multifunctional protein linked to recessively inherited Parkinson's disease (PD) due to loss of function mutations. Among its activities is anti-oxidant property leading to cytoprotection under oxidative stress conditions. A key effector of oxidant-induced cell death is the MAP3 kinase apoptosis signal-regul...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.04.002
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abstract：:Using a mouse Thy-1 allelic system (an AKR strain of Thy-1.1 was used as the host and a BALB/c strain of Thy-1.2 as the graft), characteristics of transplant-to-host axon projection and synapse formation of the olfactory bulb (OB) were studied in the hippocampal formation by immunohistochemical and ultrastructural exa...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(95)00979-5
更新日期：1995-12-01 00:00:00
abstract：:Motor imagery (MI) is a mental practice that reproduces the visual- and/or kinesthetic-modality brain activations accompanying movement. It is a useful rehabilitation technique as the affected motor cortex can be stimulated in patients with stroke and hemiplegia. However, most patients with stroke have difficulty with...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.10.002
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2010.12.005
更新日期：2011-03-01 00:00:00
abstract：:In rat models of Parkinson's disease, injections of 6-hydroxydopamine (6-OHDA) into different areas of the basal ganglia result in dopaminergic neurodegeneration in the substantia nigra. The extent and time course of the dopaminergic lesions varies between the models. While the effects on neurons have been extensively...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2008.09.001
更新日期：2008-12-01 00:00:00
abstract：:NAP-22, a neuronal tissue-enriched acidic membrane protein, is a Ca(2+)-dependent calmodulin binding protein and has similar biochemical characteristics to GAP-43 (neuromodulin). Recent biochemical studies have demonstrated that NAP-22 localizes in the membrane raft domain with a cholesterol-dependent manner. Since th...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(00)00132-2
更新日期：2000-08-01 00:00:00
abstract：:Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseas...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/j.neures.2017.02.004
更新日期：2017-07-01 00:00:00
abstract：:Alzheimer's disease (AD) patients tend to have increased plasma levels of homocysteine. However, it is unclear whether abnormality in homocysteine levels is a primary cause of Alzheimer's disease or a disease marker. In order to investigate the relative impact of Alzheimer's disease on plasma homocysteine levels, tota...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2005.09.001
更新日期：2005-12-01 00:00:00
abstract：:Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the e...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00065-8
更新日期：2003-07-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2006.08.004
更新日期：2006-12-01 00:00:00
abstract：:Both amyloid-β peptide (Aβ) deposition and neuroinflammation are considered to be early events that play pivotal roles in Alzheimer's disease (AD) pathogenesis and its associated cognitive impairment. Prophylactic anti-Aβ active immunotherapy is a promising therapeutic strategy for AD, if the Aβ-specific autoimmune re...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2017.01.003
更新日期：2017-06-01 00:00:00
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journal_title：Neuroscience research
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.neures.2006.09.004
更新日期：2007-01-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90092-5
更新日期：1993-07-01 00:00:00
abstract：:Repetitive transcranial magnetic stimulation (rTMS), which could improve learning and memory, is widely used in psychiatry and neurology as a therapeutic approach. There are few studies reporting effective countermeasures to cognition decline in astronauts during space flight. Accordingly, we examined whether rTMS was...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2019.04.002
更新日期：2020-04-01 00:00:00
abstract：:Ethanol's actions in brain have been suggested to be partially mediated by a mechanism involving the ethanol-induced activation of the endogenous opioid system. Opioid systems, which are closely linked with dopamine transmission, are thought to be affected by ethanol through alterations in the processing, release, and...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(03)00188-3
更新日期：2003-10-01 00:00:00
abstract：:Amyloid-beta (Aβ) peptides, Aβ 1-42 (Aβ42) and Aβ43 in particular, cause neurotoxicity and cell death in the brain of Alzheimer's disease (AD) at higher concentrations. Carnosic acid (CA), a phenolic diterpene compound in the labiate herbs rosemary and sage, serves as an activator for neuroprotective and neurotrophic ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2014.12.003
更新日期：2015-05-01 00:00:00
abstract：:Catecholamine neurotransmitters--dopamine, noradrenaline (norepinephrine), adrenaline (epinephrine)--are synthesized in catecholaminergic neurons from tyrosine, via dopa, dopamine and noradrenaline, to adrenaline. Four enzymes are involved in the biosynthesis of adrenaline: (1) tyrosine 3-mono-oxygenase (tyrosine hydr...
journal_title：Neuroscience research
pub_type： 杂志文章,评审
doi：10.1016/0168-0102(91)90001-f
更新日期：1991-10-01 00:00:00
abstract：:To elucidate the interaction between nitric oxide (NO) and substance P (SP) in neurogenic inflammatory responses, we measured the change in the degree of Evans blue leakage and NO levels in perfusate from the subcutaneous space in the rat instep following noxious heat stimulation (47 degrees C for 30 min). Furthermore...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(99)00107-8
更新日期：2000-01-01 00:00:00
abstract：:Medial preoptic area (MPA), supraoptic nucleus (SON), magnocellular (MaPVN) and parvocellular (PaPVN) paraventricular hypothalamic nuclei, and mesencephalic lateral tegmentum (MLT) are involved in maternal behavior, parturition and lactation. This study investigated the FosB and Fos immunoreactivity in these regions o...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(98)00100-x
更新日期：1998-12-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(93)90105-y
更新日期：1993-10-01 00:00:00
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journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(94)90073-6
更新日期：1994-11-01 00:00:00
abstract：:Expressions of Cry1 and Cry2 mRNA in the rat pineal gland were examined by Northern blot. The levels of Cry1 and Cry2 transcript had a marked circadian rhythm with peaks at circadian time (CT) 20 in constant darkness. But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm. Furthermore, a signific...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/s0168-0102(01)00255-3
更新日期：2001-09-01 00:00:00
abstract：:A brain-machine interface (BMI) uses neurophysiological signals from the brain to control external devices, such as robot arms or computer cursors. Combining augmented reality with a BMI, we show that the user's brain signals successfully controlled an agent robot and operated devices in the robot's environment. The u...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2009.10.006
更新日期：2010-02-01 00:00:00
abstract：:The alar plate of the prosencephalon differentiates into a tectum-like structure when transplanted into the mesencephalon around the 10-somite stage. Here, we report on the projection pattern of the retinal ganglion cells to the transplants. Optic nerve fibers were labeled with horseradish peroxidase (HRP) and 3H-prol...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(91)90042-w
更新日期：1991-08-01 00:00:00
abstract：:Changes in the expression of estrogen-related substances in monkeys' brains at the menopausal transition, when estrogen deficit starts to occur, have not yet been examined thoroughly. In the present study, we immunohistochemically investigated the expression levels of estrogen receptor beta (ERβ) and aromatase (local ...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2011.10.007
更新日期：2012-02-01 00:00:00
abstract：:Speech prosody is considered to be one of the most important sources of information for infants in acquiring their native language. Using multi-channel near-infrared spectroscopy in 10-month-old infants, we examined cortical activation when normal and flattened speech sounds were presented to the infants. The flattene...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/j.neures.2007.05.005
更新日期：2007-09-01 00:00:00
abstract：:Projection fields in the striatum and claustrum from eye movement-evoking cerebral cortices (EMECs) in the cat were investigated using the WGA-HRP tracing method under electrophysiological guidance to place WGA-HRP in the appropriate sites. The EMECs in the frontal cortex, which are located in the medial wall under th...
journal_title：Neuroscience research
pub_type： 杂志文章
doi：10.1016/0168-0102(90)90033-b
更新日期：1990-08-01 00:00:00
