Immunohistochemical demonstration of ganglioside GD3 in the central nervous system.


:Immunohistochemical staining for GD3 in adult rat brain was carried out using mouse IgM anti-GD3 monoclonal antibody (DSG-1). Neuronal cells in the cerebral cortex, striatum, hippocampus and various nuclei of the thalamus were immunoreactive. In the cerebellum, Purkinje cells, granule cells and also basket cells were immunoreactive. However, astrocytes and oligodendrocytes in the cerebrum and cerebellum were not immunoreactive. The GD3 immunoreactivity was located in the cytoplasm. These findings are of considerable interest, being the first reported demonstration of GD3 in the adult rat brain. The implications and possible significance of the presence of GD3 are discussed.


Neurosci Res


Neuroscience research


Kawai K,Mori M,Watarai S,Yasuda T




Has Abstract


1994-03-01 00:00:00














  • Clustering and anchoring mechanisms of molecular constituents of postsynaptic scaffolds in dendritic spines.

    abstract::Recent technological progress has yielded great amounts of information about the molecular constituents of postsynaptic scaffolds in the dendritic spine. Actin filaments are major cytoskeletal elements in the dendritic spine, and they functionally interact with neurotransmitter receptors via regulatory actin-binding p...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Shirao T,Sekino Y

    更新日期:2001-05-01 00:00:00

  • Substance P immunoreactivity in the vagal nerve of mice.

    abstract::After horseradish peroxidase was applied to the main trunk of the mouse vagal nerve, anterogradely labeled cells in the vagal ganglia and fibers in the solitary complex, and retrogradely labeled cells in the dorsal motor nucleus and the ambiguous nucleus were observed. Most of the cells in the nodose ganglion were lab...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Funakoshi K,Kusakabe T,Kadota T,Goris RC,Kishida R

    更新日期:1989-12-01 00:00:00

  • Nerve growth factor-like activity in the rat pituitary intermediate lobe.

    abstract::Nerve growth factor (NGF)-like immunoreactivity was demonstrated in the rat pituitary intermediate lobe by indirect immunofluorescence method using antisera specific to beta-NGF isolated from adult male mouse submaxillary salivary gland. Co-culture of frozen or fresh intermediate lobes with newborn rat superior cervic...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Soinila S,Lakshmanan J,Lahtinen T

    更新日期:1988-12-01 00:00:00

  • Tetrodotoxin-resistant conductivity and spinal effects of cutaneous C-fibre afferents in the rat.

    abstract::The effect of the sodium channel blocking agent tetrodotoxin (TTX) on signal processing in afferent fibres of dorsal roots was tested in Sprague-Dawley rats. TTX applied to the dorsal roots L4-L6 blocked the fast afferent volleys from the sural nerve, which was stimulated electrically with supramaximal strength for A-...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Steffens H,Hoheisel U,Eek B,Mense S

    更新日期:2001-04-01 00:00:00

  • Confocal and multiphoton calcium imaging of the enteric nervous system in anesthetized mice.

    abstract::Most imaging studies of the enteric nervous system (ENS) that regulates the function of the gastrointestinal tract are so far performed using preparations isolated from animals, thus hindering the understanding of the ENS function in vivo. Here we report a method for imaging the ENS cellular network activity in living...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Motegi Y,Sato M,Horiguchi K,Ohkura M,Gengyo-Ando K,Ikegaya Y,Fusamae Y,Hongo Y,Suzuki M,Ogawa K,Takaki M,Nakai J

    更新日期:2020-02-01 00:00:00

  • Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic substrates.

    abstract::Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 a...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Bernstein DL,Nayak SU,Oliver CF,Rawls SM,Rom S

    更新日期:2020-06-01 00:00:00

  • Functional segregation of the inferior frontal gyrus for syntactic processes: a functional magnetic-resonance imaging study.

    abstract::We used functional magnetic resonance imaging in 18 normal volunteers to determine whether there is separate representation of syntactic, semantic, and verbal working memory processing in the left inferior frontal gyrus (GFi). We compared a sentence comprehension task with a short-term memory maintenance task to ident...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Uchiyama Y,Toyoda H,Honda M,Yoshida H,Kochiyama T,Ebe K,Sadato N

    更新日期:2008-07-01 00:00:00

  • Dynamic properties, interactions and adaptive modifications of vestibulo-ocular reflex and optokinetic response in mice.

    abstract::Dynamic properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic response (OKR) were studied in mice. The VOR was examined in the dark (VORD), in the light (VORL) and in the condition in which most of the visual field moves synchronously with the head motion (VORF). A mouse and/or a surrounding screen wi...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Iwashita M,Kanai R,Funabiki K,Matsuda K,Hirano T

    更新日期:2001-03-01 00:00:00

  • DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway.

    abstract::Disrupted-in-Schizophrenia 1 (DISC1) is a susceptibility gene for major mental illnesses, including bipolar disorder and schizophrenia. Although the roles of DISC1 in nervous system development and functions are increasingly recognized, pathophysiological mechanisms underlying a range of neuropsychiatric symptoms caus...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Flores R 3rd,Hirota Y,Armstrong B,Sawa A,Tomoda T

    更新日期:2011-09-01 00:00:00

  • Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice.

    abstract::Fatty acid-binding protein 3 (Fabp3) is an intracellular lipid trafficking protein that mediates energy metabolism and long-chain fatty acid-related signaling. Fabp3 is expressed in the spiral ganglion neurons and supporting cells of the organ of Corti. However, it is unclear what role Fabp3 plays in the cochlea. Here...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Suzuki J,Oshima T,Yoshida N,Kimura R,Takata Y,Owada Y,Kobayashi T,Katori Y,Osumi N

    更新日期:2014-04-01 00:00:00

  • Thalamic reticular nucleus in the thalamocortical loop.

    abstract::Dynamic binding of different brain areas is critical for various cognitive functions. The thalamic reticular nucleus (TRN) is a GABAergic nucleus that constrains information flow through thalamocortical loop by providing inhibitory innervation to the thalamus. In this review, I summarize anatomical and single-cell-lev...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Takata N

    更新日期:2020-07-01 00:00:00

  • Chloride homeodynamics underlying modal shifts in cellular and network oscillations.

    abstract::γ-Aminobutyric acid (GABA) generally induces hyperpolarization and inhibition in the adult brain, but causes depolarization (and can be excitatory) in the immature brain. Depolarizing GABA actions are necessary for neurogenesis, differentiation, migration, and synaptogenesis. Additionally, the conversion of GABA respo...

    journal_title:Neuroscience research

    pub_type: 杂志文章,评审


    authors: Fukuda A

    更新日期:2020-07-01 00:00:00

  • Mifepristone reduces hypothalamo-pituitary-adrenal axis activation and restores weight loss in rats subjected to dietary restriction and methylphenidate administration.

    abstract::This study evaluates the efficacy of mifepristone on weight restoration in rats subjected to dietary restriction and methylphenidate administration. 25 female rats aged between 9 and 12 months were divided into 2 groups: 5 controls (exposed only to dietary restriction) and 20 rats that were administered 5 mg/kg/d of m...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Bou Khalil R,Smayra V,Saliba Y,Hajal J,Bakhos JJ,Souaiby L,Richa S,Tamraz J,Farès N

    更新日期:2018-10-01 00:00:00

  • Unmasking of silent "task-related" neuronal activity in the monkey prefrontal cortex by a GABA(A) antagonist.

    abstract::To examine the role of GABA on prefrontal neuronal activity in the control of behavior, a GABA(A) receptor antagonist, bicuculline methiodite (BMI), was iontophoretically applied to prefrontal neurons while monkeys performed a visual reaction time task. Iontophoretic application of BMI uncovered "task-related" activit...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Sawaguchi T

    更新日期:2001-01-01 00:00:00

  • Effect of isolation on classical conditioned histamine release in guinea pigs.

    abstract::To investigate the effect of abrupt or non-abrupt isolation stress on the classical conditioned histamine release, socially isolated or paired guinea pigs underwent conditioning procedures in which ovalbumin (OA) as an unconditioned stimulus (US) and dimethylsulfide (sulfur smelling) as a conditioned stimulus (CS) wer...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Irie M,Nagata S,Endo Y

    更新日期:2002-09-01 00:00:00

  • Hydrogen sulfide regulates intracellular pH in rat primary cultured glia cells.

    abstract::Intracellular pH (pH(i)) plays an important role in the regulation of central nervous system function. In the present study, we examined whether hydrogen sulfide (H(2)S), a recently recognized neuromodulator, regulates pH(i) in rat primary cultured glia cells. pH(i) was measured with a fluorescent sensitive dye, BCECF...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Lu M,Choo CH,Hu LF,Tan BH,Hu G,Bian JS

    更新日期:2010-01-01 00:00:00

  • Multiphasic responses of cerebellar Purkinje cells to 1S,3R-ACPD: an in vivo study.

    abstract::The effects of iontophoretically applied (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), an agonist of metabotropic glutamate receptors, were examined in rat cerebellar Purkinje cells in vivo. Multibarrel electrodes were used for extracellular recordings of spontaneous single unit discharges and iontop...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Lingenhöhl K,Knöpfel T,Olpe HR

    更新日期:1993-12-01 00:00:00

  • Spectral dissociation of lateralized brain rhythms.

    abstract::Using high resolution spectral methods to uncover neuromarkers of social, cognitive and behavioral function, we have found that hemi-lateralized pairs of oscillations such as left and right occipital alpha or left and right rolandic mu dissociate spectrally. That is, they show a shifted frequency distribution, with on...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Tognoli E,Kelso JAS

    更新日期:2020-07-01 00:00:00

  • My thoughts through a robot's eyes: an augmented reality-brain-machine interface.

    abstract::A brain-machine interface (BMI) uses neurophysiological signals from the brain to control external devices, such as robot arms or computer cursors. Combining augmented reality with a BMI, we show that the user's brain signals successfully controlled an agent robot and operated devices in the robot's environment. The u...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Kansaku K,Hata N,Takano K

    更新日期:2010-02-01 00:00:00

  • Inhibition of TGF-beta1 promotes functional recovery after spinal cord injury.

    abstract::Trauma to the spinal cord initiates a series of cellular and biochemical processes that damage both neurons and glia. TGF-beta and its receptors are expressed around the injury site following a spinal cord injury. Here, we report that the intrathecal administration of a neutralizing antibody to TGF-beta1 in rats with ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Kohta M,Kohmura E,Yamashita T

    更新日期:2009-12-01 00:00:00

  • Acupuncture of the sacral vertebrae suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center.

    abstract::Acupuncture of the sacral vertebrae has therapeutic effects in patients with overactive bladders. The mechanism of these effects, however, remains unclear. The present study, using urethane-anesthetized rats, investigated the effects of acupuncture stimulation of the sacral vertebrae on bladder activity and bladder ac...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Wang H,Tanaka Y,Kawauchi A,Miki T,Kayama Y,Koyama Y

    更新日期:2012-01-01 00:00:00

  • Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus.

    abstract::The actin cytoskeleton plays a critical role in the cellular morphological changes. Its organization is essential for neurite extension and synaptogenesis under the processes of neuronal development. Recently, neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE) have bee...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Tsuchiya D,Kitamura Y,Takata K,Sugisaki T,Taniguchi T,Uemura K,Miki H,Takenawa T,Shimohama S

    更新日期:2006-12-01 00:00:00

  • The cat cervical dorsal root ganglia: general cell-size characteristics and comparative study of neck muscle, neck cutaneous and phrenic afferents.

    abstract::Sizes of neuronal somata in the cat cervical dorsal root ganglia were determined at different levels (C1-C8). The average value and class distribution of mean cell diameter were analyzed. The ganglia from C1 to C5 could be clearly distinguished from those at levels of brachial plexus afferents (C6-C8) with respect to ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Rose D,Larnicol N,Duron B

    更新日期:1990-02-01 00:00:00

  • Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity.

    abstract::Changes in levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) in various regions of the rat brain following kainic acid-induced seizure activity were investigated. BDNF protein, as measured by a two-site enzyme immunoassay, increased transiently 12-24 h after the in...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Katoh-Semba R,Takeuchi IK,Inaguma Y,Ito H,Kato K

    更新日期:1999-10-01 00:00:00

  • Different perceptual sensitivities for Chernoff's face between children and adults.

    abstract::The aim of this study was to investigate the differences between children and adults in recognizing facial expressions of simple line drawings of "Chernoff's face". First, the angles of the eyebrows and mouth of Chernoff's face were changed in a stepwise way with a personal computer, and the emotional response of the ...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Tsurusawa R,Goto Y,Mitsudome A,Nakashima T,Tobimatsu S

    更新日期:2008-02-01 00:00:00

  • Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia.

    abstract::The synthesis of glial-fibrillary acidic protein (GFAP) or the re-expression of progenitor markers such as Nestin increases in reactive astrocytes after brain ischemia. We investigated the dynamics of reactive astrocytes after transient focal brain ischemia by examining the expression of Musashi1 (Msi1), an RNA-bindin...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Oki K,Kaneko N,Kanki H,Imai T,Suzuki N,Sawamoto K,Okano H

    更新日期:2010-04-01 00:00:00

  • Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus.

    abstract::We investigated the distribution and colocalization pattern of the two corticosteroid receptors, mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), in the hippocampus and hypothalamus, the main target regions of corticosterone in the rat brain, using double immunofluorescence histochemistry in conjuncti...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Han F,Ozawa H,Matsuda K,Nishi M,Kawata M

    更新日期:2005-04-01 00:00:00

  • Area dependent expression of ZNF312 in human fetal cerebral cortex.

    abstract::The human cerebral neocortex is divided into six layers consisting of specific neuronal cell types and connections. To determine the distribution of cortical neurons during early development, we examined the expressions of layer-specific markers in human midterm fetal brains. Layer V marker ZNF312 is expressed in most...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Zhu H,Yang Y,Gao J,Tao H,Qu C,Qu J,Chen J

    更新日期:2010-09-01 00:00:00

  • Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive degeneration of motoneurons. We have demonstrated that hepatocyte growth factor (HGF) attenuates loss of both spinal and brainstem motoneurons of ALS model mice expressing mutated human SOD1(G93A) (G93A). This study was designed to ass...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Kadoyama K,Funakoshi H,Ohya-Shimada W,Nakamura T,Matsumoto K,Matsuyama S,Nakamura T

    更新日期:2009-10-01 00:00:00

  • Excitatory synapse in the rat hippocampus in tissue culture and effects of aniracetam.

    abstract::Excitatory synaptic connections between rat hippocampal neurons were established in tissue culture. The electrophysiological and pharmacological properties of these synapses were studied with the use of the tight-seal whole-cell recording technique. The excitatory postsynaptic current (EPSC) in a dissociated CA1 neuro...

    journal_title:Neuroscience research

    pub_type: 杂志文章


    authors: Ozawa S,Iino M,Abe M

    更新日期:1991-10-01 00:00:00