Abstract：
:Development of neurofibrillary tangles (NFTs) is a pathological hallmark in various neurodegenerative disorders including Alzheimer's disease (AD). Recently, we identified a granular tau oligomer having a pre-filamentous structure. To determine the role of this oligomer in NFT formation, we quantified the amount of granular tau oligomer in 21 frontal cortex samples, each displaying varying degrees of Braak-staged NFT pathology. Here we report that granular tau oligomer levels in frontal cortex were significantly increased, even in brains displaying Braak-stage I neuropathology, a stage at which clinical symptoms of AD and NFTs in frontal cortex are believed to be absent. This suggests that increases in granular tau oligomer levels occur before NFTs form and before individuals manifest clinical symptoms of AD. Increased granular tau oligomer levels, therefore, may lead to NFT formation in frontal cortex, eventually leading to the development of AD. Thus, increases in granular tau oligomer levels may represent a very early sign of NFT formation and AD.
journal_name
Neurosci Resjournal_title
Neuroscience researchauthors
Maeda S,Sahara N,Saito Y,Murayama S,Ikai A,Takashima Adoi
10.1016/j.neures.2005.11.009subject
Has Abstractpub_date
2006-03-01 00:00:00pages
197-201issue
3eissn
0168-0102issn
1872-8111pii
S0168-0102(05)00311-1journal_volume
54pub_type
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