DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway.

abstract：:Neurons in the inferior temporal (IT) cortex respond not only to the shape, color or texture of objects, but to the horizontal positional disparity of visual features in the right and left retinal images. IT neurons with similar shape selectivity cluster in columns. In this study, we examined how IT neurons are spatia...

journal_title：Neuroscience research

authors： Yoshiyama K,Uka T,Tanaka H,Fujita I

更新日期：2004-02-01 00:00:00

abstract：:Nine healthy male volunteers (mean age of 24) participated in two experimental sessions of random crossover design: a bright light (5000 lux for 5 h from 00:00 to 05:00 h) session and a dim light (10 lux for 5 h from 00:00 to 05:00 h) session. Subsequently participants entered an ultra-short sleep-wake schedule for 26...

journal_title：Neuroscience research

authors： Kubota T,Uchiyama M,Suzuki H,Shibui K,Kim K,Tan X,Tagaya H,Okawa M,Inoue S

更新日期：2002-02-01 00:00:00

abstract：:Fifteen rabbits were classically conditioned using stimulation of the right pontine nuclei as a conditioned stimulus and a corneal airpuff as an unconditioned stimulus. After conditioning criterion was reached, the stimulation conditioned stimulus was transferred to the left pontine nuclei and the rate of conditioned ...

journal_title：Neuroscience research

authors： Steinmetz JE,Rosen DJ,Woodruff-Pak DS,Lavond DG,Thompson RF

更新日期：1986-09-01 00:00:00

abstract：:The interaction of neurotransmitter receptors with the underlying cytoskeleton via subsynaptic proteins is an important mechanism for the targeting of the receptors to synapses in the central nervous system. We show that delta glutamate receptors (delta receptors), expressed predominantly in the dendritic spines of ce...

journal_title：Neuroscience research

authors： Hirai H,Matsuda S

更新日期：1999-09-01 00:00:00

abstract：:Excitatory synaptic transmission from two input systems to hippocampal CA3 pyramidal neurons was investigated by the whole-cell patch-clamp technique for thin slice preparation, with special reference to long-term potentiation (LTP) in these systems. Excitatory postsynaptic currents (EPSCs) evoked by fimbrial stimulat...

journal_title：Neuroscience research

authors： Katsuki H,Kaneko S,Tajima A,Satoh M

更新日期：1991-11-01 00:00:00

abstract：:Communication in the central nervous system (CNS) occurs through initiation and propagation of action potentials at excitable domains along axons. Action potentials generated at the axon initial segment (AIS) are regenerated at nodes of Ranvier through the process of saltatory conduction. Proper formation and maintena...

journal_title：Neuroscience research

authors： Griggs RB,Yermakov LM,Susuki K

更新日期：2017-03-01 00:00:00

abstract：:It has previously been shown that when a target is moved, cats can change the direction of ongoing target-reaching with brief latency suggesting a tectal relay. Switching of target-reaching has now been investigated after spinal lesions: (1) dorsally in C5 interrupting cortico- (CS) and rubrospinal (RS) fibres to fore...

journal_title：Neuroscience research

authors： Alstermark B,Górska T,Lundberg A,Pettersson LG,Walkowska M

更新日期：1987-10-01 00:00:00

abstract：:Whole-cell recordings were performed to examine the morphological properties of electrophysiologically classified area postrema (AP) neurons in rat brain slices. Using electrophysiological criteria, AP neurons were subdivided into three groups: (1) cells displaying both the hyperpolarization-activated cation current (...

journal_title：Neuroscience research

authors： Funahashi M,Mitoh Y,Akaike T,Matsuo R

更新日期：2006-01-01 00:00:00

abstract：:In the mammalian central nervous system (CNS), transcription factor activator protein 2 (AP-2) is one of the critical regulatory factors for neural gene expression and neural development. As AP-2 has diverged into several subtypes, i.e. AP-2alpha, -2beta, and 2.2, we investigated the distribution of the AP-2 subtypes ...

journal_title：Neuroscience research

authors： Shimada M,Konishi Y,Ohkawa N,Ohtaka-Maruyama C,Hanaoka F,Makino Y,Tamura T

更新日期：1999-04-01 00:00:00

abstract：:Sensitivities of neurons to acetylcholine (ACh), noradrenaline (NA) and dopamine (DA) were investigated at different depths of the dorsolateral prefrontal cortex (PFC) in awake or halothane-anesthetized macaque monkeys, using microiontophoretic techniques with multi-barreled electrodes. The laminar locations of tested...

journal_title：Neuroscience research

authors： Sawaguchi T,Matsumura M

更新日期：1985-04-01 00:00:00

abstract：:Excitatory synaptic connections between rat hippocampal neurons were established in tissue culture. The electrophysiological and pharmacological properties of these synapses were studied with the use of the tight-seal whole-cell recording technique. The excitatory postsynaptic current (EPSC) in a dissociated CA1 neuro...

journal_title：Neuroscience research

authors： Ozawa S,Iino M,Abe M

更新日期：1991-10-01 00:00:00

abstract：:Metabolism of amyloid-beta peptide (Abeta) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Since neprilysin is the only rate-limiting catabolic peptidase proven by reverse genetics to participate in Abeta metabolism in vivo, we performed detailed immunohistochemical analysis of nepri...

journal_title：Neuroscience research

authors： Fukami S,Watanabe K,Iwata N,Haraoka J,Lu B,Gerard NP,Gerard C,Fraser P,Westaway D,St George-Hyslop P,Saido TC

更新日期：2002-05-01 00:00:00

abstract：:Damage to the central nervous system (CNS) leads to disruption of the vascular network, causing vascular dysfunction. Vascular dysfunction is the major event in the pathogenesis of CNS diseases and is closely associated with the severity of neuronal dysfunction. The suppression of vascular dysfunction has been conside...

journal_title：Neuroscience research

authors： Muramatsu R,Yamashita T

更新日期：2014-04-01 00:00:00

abstract：:The effects of substance P (SP) on cholinergic transmission were studied at the neuromuscular junction of frogs by intracellular and voltage-clamp recording methods. Bath application of SP increased the amplitude of end-plate potential (e.p.p.) evoked in either low-Ca2+ -high Mg2+ or curare-containing solution. SP at ...

journal_title：Neuroscience research

authors： Akasu T

更新日期：1986-05-01 00:00:00

abstract：:Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO). Hamster SCO consists of the ependymal and hypendymal cell layers, the latter being arranged as ro...

journal_title：Neuroscience research

authors： Tsai MH,Wu CH,Chen WP,Shieh JY,Wen CY

更新日期：2003-09-01 00:00:00

abstract：:Afferent neurons entering the central nervous systems of vertebrates and invertebrates receive presynaptic inhibition on their axon terminals. This usually involves an increase in membrane conductance (shunting) and depolarization (primary afferent depolarization, PAD). In arachnids and crustaceans the peripherally lo...

journal_title：Neuroscience research

authors： French AS,Panek I,Torkkeli PH

更新日期：2006-06-01 00:00:00

abstract：:Acupuncture of the sacral vertebrae has therapeutic effects in patients with overactive bladders. The mechanism of these effects, however, remains unclear. The present study, using urethane-anesthetized rats, investigated the effects of acupuncture stimulation of the sacral vertebrae on bladder activity and bladder ac...

journal_title：Neuroscience research

authors： Wang H,Tanaka Y,Kawauchi A,Miki T,Kayama Y,Koyama Y

更新日期：2012-01-01 00:00:00

abstract：:Using high resolution spectral methods to uncover neuromarkers of social, cognitive and behavioral function, we have found that hemi-lateralized pairs of oscillations such as left and right occipital alpha or left and right rolandic mu dissociate spectrally. That is, they show a shifted frequency distribution, with on...

journal_title：Neuroscience research

authors： Tognoli E,Kelso JAS

更新日期：2020-07-01 00:00:00

abstract：:The occurrence of multiple proteoglycan species is a characteristic of the brain. The structural features of individually characterized proteoglycans in the brain are first introduced in brief, then some examples are shown that suggest a relationship between multiple proteoglycans and the many distinct cell types and ...

journal_title：Neuroscience research

authors： Oohira A,Katoh-Semba R,Watanabe E,Matsui F

更新日期：1994-09-01 00:00:00

abstract：:Using immunohistochemistry and retrograde transport techniques, this study demonstrates that serotonin (5-HT) cells in the dorsal tegmental gray of the pons at rostrocaudal from P1 to P6 levels are sources of bilateral serotonergic projections to the gigantocellular tegmental field of the medial pontine and medullary ...

journal_title：Neuroscience research

authors： Kobayashi Y,Matsuyama K,Mori S

更新日期：1994-07-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor 2B gene (GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated cont...

journal_title：Neuroscience research

authors： Kim JH,Park M,Yang SY,Jeong BS,Yoo HJ,Kim JW,Chung JH,Kim SA

更新日期：2006-10-01 00:00:00

abstract：:The radioprotective effect of herb epimedium (or yin yang huo) extract (5 g/kg, oral administration daily for 4 weeks) on neurogenesis and cognition after acute radiation exposure with 5.5 Gy was evaluated in Balb/c mice by behavioral tests and immunohistochemical study. The results indicated that epimedium extract co...

journal_title：Neuroscience research

authors： Wang SW,Ren BX,Qian F,Luo XZ,Tang X,Peng XC,Huang JR,Tang FR

更新日期：2019-08-01 00:00:00

abstract：:Chemokines related neuroinflammation and N-methyl-d-aspartate receptor (NMDAR) mediated nociceptive transmission are pivotal determinants in the pathogenesis of opioid-induced hyperalgesia (OIH), but little is known about specific mechanism and treatment. Chemokine CXCL12 with its receptor CXCR4 is implicated in diffe...

journal_title：Neuroscience research

authors： Li T,Wang H,Wang J,Chen Y,Yang C,Zhao M,Wang G,Yang Z

更新日期：2019-07-01 00:00:00

abstract：:Sleep disturbances are common in psychiatric disorders, but the causal relationship between the two and the underlying genetic factors is unclear. The DISC1 gene is strongly linked to mood disorders and schizophrenia in a Scottish pedigree. In an earlier study we found a sleep homeostasis disturbance in a Drosophila m...

journal_title：Neuroscience research

authors： Jaaro-Peled H,Altimus C,LeGates T,Cash-Padgett T,Zoubovsky S,Hikida T,Ishizuka K,Hattar S,Mongrain V,Sawa A

更新日期：2016-11-01 00:00:00

abstract：:In the rat striatum numerous secretagogin (SCGN) positive neurons were scattered. They were heterogeneous in their morphological and chemical properties. We examined the colocalization of SCGN with known four interneuron markers, parvalbumin (PV), calretinin (CR), nitric oxide synthase (NOS) and choline acetyl transfe...

journal_title：Neuroscience research

authors： Kosaka T,Yasuda S,Kosaka K

更新日期：2017-06-01 00:00:00

abstract：:Intrastriatal hemorrhage in rats causes neurodegenaration of the substantia nigra (SN) followed by the appearance of ED1(+) cells (macrophage/microglia). ED1(+) cells were observed for at least 8 weeks after hemorrhage. Phosphorylation of p38 mitogen-activated protein kinase (MAPK) was shown in ED1(+) cells with the e...

journal_title：Neuroscience research

authors： Imamura N,Hida H,Aihara N,Ishida K,Kanda Y,Nishino H,Yamada K

更新日期：2003-07-01 00:00:00

abstract：:Withdrawal may be a natural model to study craving and compulsive drug seeking, since craving can be viewed as a conditioned dysphoric state. It has been suggested that functional connectivity between brain areas may be of major value in explaining excessive craving and compulsive drug seeking by providing essential l...

journal_title：Neuroscience research

authors： Fingelkurts AA,Fingelkurts AA,Kivisaari R,Autti T,Borisov S,Puuskari V,Jokela O,Kähkönen S

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Global field synchronization (GFS) has recently been introduced to measure functional synchronization in frequency-domain EEG data. This study explored GFS values and its clinical significance in patients with Alzheimer's disease (AD). METHOD:EEGs were recorded from 22 AD patients and 23 age-matched healthy...

journal_title：Neuroscience research

authors： Park YM,Che HJ,Im CH,Jung HT,Bae SM,Lee SH

更新日期：2008-10-01 00:00:00

abstract：:In lightly alpha-chloralose anaesthetized cats, activity was recorded simultaneously from 2-4 primary muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles. Increased tension in medial or lateral collateral ligament was found to evoke changes in the responses of the primary spi...

journal_title：Neuroscience research

authors： Sojka P,Sjölander P,Johansson H,Djupsjöbacka M

更新日期：1991-06-01 00:00:00

abstract：:We previously found that ginsenoside Rd (GSRd), one of the main active ingredients in Panax Ginseng, attenuates H(2)O(2)-induced oxidative injury in PC12 cells. Mounting evidence suggests that the oxidative stress is crucially involved in the pathophysiologic process of ischemia. In the present study, we examined the ...

journal_title：Neuroscience research

authors： Ye R,Li N,Han J,Kong X,Cao R,Rao Z,Zhao G

更新日期：2009-07-01 00:00:00