Radioprotective effect of epimedium on neurogenesis and cognition after acute radiation exposure.

Abstract:

:The radioprotective effect of herb epimedium (or yin yang huo) extract (5 g/kg, oral administration daily for 4 weeks) on neurogenesis and cognition after acute radiation exposure with 5.5 Gy was evaluated in Balb/c mice by behavioral tests and immunohistochemical study. The results indicated that epimedium extract could improve animal weight loss, locomotor activity and spatial learning and memory which are similar to pre-irradiation intraperitoneal injection (100 mg/kg) of amifostine phosphate, a well- known radioprotective drug. Immunohistochemical study showed that epimedium extract prevented the loss of proliferation cells, newly generated neurons, and interneurons in the hilus, in particular, the subgranular zone of the dentate gyrus. It suggests that herb epimedium may be a promising radio-neuro-protective drug to prevent radiation-induced neuropsychological disorders.

journal_name

Neurosci Res

journal_title

Neuroscience research

authors

Wang SW,Ren BX,Qian F,Luo XZ,Tang X,Peng XC,Huang JR,Tang FR

doi

10.1016/j.neures.2018.08.011

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

46-53

eissn

0168-0102

issn

1872-8111

pii

S0168-0102(18)30380-8

journal_volume

145

pub_type

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