Transdiagnostic versus diagnosis-specific cbt for anxiety disorders: a preliminary randomized controlled noninferiority trial.

Abstract:

BACKGROUND:Transdiagnostic cognitive-behavioral treatments for anxiety disorders have been gaining increased attention and empirical study in recent years. Despite this, research on transdiagnostic anxiety treatments has, to date, relied on open trials, or comparisons to waitlist conditions, published benchmarks, or relaxation-based interventions. METHODS:The current study was a randomized clinical trial examining the efficacy of a 12-week transdiagnostic cognitive-behavioral group treatment in comparison to 12-week diagnosis-specific group Cognitive-Behavioral Therapy (CBT) protocols for panic disorder, social anxiety disorder, and generalized anxiety disorder. RESULTS:Results from 46 treatment initiators suggested significant improvement during treatment, strong evidence for treatment equivalence across transdiagnostic and diagnosis-specific CBT conditions, and no differences in treatment credibility. CONCLUSIONS:This study provides evidence supporting the efficacy of transdiagnostic CBT by comparison to current gold-standard diagnosis-specific CBT for social anxiety disorder, generalized anxiety disorder, and panic disorder. Transdiagnostic group CBT has the benefit of potentially easing dissemination and increasing access to evidence-based treatments for anxiety without sacrificing efficacy.

journal_name

Depress Anxiety

journal_title

Depression and anxiety

authors

Norton PJ,Barrera TL

doi

10.1002/da.21974

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

874-82

issue

10

eissn

1091-4269

issn

1520-6394

journal_volume

29

pub_type

杂志文章,随机对照试验
  • Comparison of pramipexole, fluoxetine, and placebo in patients with major depression.

    abstract::Pramipexole, a dopamine D2 receptor agonist, was tested in 174 patients with major depression, with or without melancholia and without psychotic features. Three daily dose levels (0.375 mg, 1.0 mg, and 5.0 mg) were compared to fluoxetine (Prozac) at 20 mg and placebo in a randomized, double-blind, parallel-group study...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1520-6394(2000)11:2<58::aid-da2>3.0.

    authors: Corrigan MH,Denahan AQ,Wright CE,Ragual RJ,Evans DL

    更新日期:2000-01-01 00:00:00

  • Stability of chronotype over a 7-year follow-up period and its association with severity of depressive and anxiety symptoms.

    abstract:BACKGROUND:Chronotype is an individual's preferred timing of sleep and activity, and is often referred to as a later chronotype (or evening-type) or an earlier chronotype (or morning-type). Having an evening chronotype is associated with more severe depressive and anxiety symptoms. Based on these findings it is has bee...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22995

    authors: Druiven SJM,Hovenkamp-Hermelink JHM,Knapen SE,Kamphuis J,Haarman BCM,Penninx BWJH,Antypa N,Meesters Y,Schoevers RA,Riese H

    更新日期:2020-05-01 00:00:00

  • The interaction of 5-HTT variation, recent stress, and resilience on current anxiety levels in adolescents and young adults from the general population.

    abstract:BACKGROUND:Previous work on gene-environment (GxE) interplay concerning anxiety has focused on the interaction of 5-HTTLPR with childhood adversities or traumatic events whereas the impact of recent stressors is understudied, as is the integration of resilience. The current study aimed to investigate the interactive ef...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.23101

    authors: Ollmann TM,Voss C,Venz J,Seidl E,Hoyer J,Kische H,Pieper L,Schiele MA,Domschke K,Beesdo-Baum K

    更新日期:2020-10-14 00:00:00

  • Convergent, discriminant, and criterion-related validity of the Social Phobia and Anxiety Inventory.

    abstract::The psychometric properties of the Social Phobia Anxiety Inventory (SPAI) were assessed in a sample of participants who either had a primary diagnosis of social phobia or were normal volunteers. Positive evidence was obtained on the SPAI's concurrent and predictive convergent validity: it was significantly correlated ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:

    authors: Rodebaugh TL,Chambless DL,Terrill DR,Floyd M,Uhde T

    更新日期:2000-01-01 00:00:00

  • Investigation of telomere length and psychological stress in rape victims.

    abstract:BACKGROUND:Women are at an increased risk of depression and other mental health problems following rape. Various etiological factors for depression, including predisposing genetic factors, have been identified. Telomeres are repetitive nucleoprotein structures located at chromosomal ends that protect them from prematur...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20903

    authors: Malan S,Hemmings S,Kidd M,Martin L,Seedat S

    更新日期:2011-12-21 00:00:00

  • Physical activity offsets genetic risk for incident depression assessed via electronic health records in a biobank cohort study.

    abstract:BACKGROUND:Physical activity is increasingly recognized as an important modifiable factor for depression. However, the extent to which individuals with stable risk factors for depression, such as high genetic vulnerability, can benefit from the protective effects of physical activity, remains unknown. Using a longitudi...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22967

    authors: Choi KW,Zheutlin AB,Karlson RA,Wang MJ,Dunn EC,Stein MB,Karlson EW,Smoller JW

    更新日期:2020-02-01 00:00:00

  • Where does obsessive-compulsive disorder belong in DSM-V?

    abstract::A reclassification of obsessive-compulsive disorder (OCD) into a new diagnostic category spectrum of "obsessive-compulsive spectrum disorders" (OCSDs) has recently been proposed, with considerable debate, for the forthcoming Diagnostic and Statistical Manual-Fifth Edition (DSM-V). This paper provides a critical analys...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20488

    authors: Storch EA,Abramowitz J,Goodman WK

    更新日期:2008-01-01 00:00:00

  • Obsessive-compulsive disorder in youth with and without a chronic tic disorder.

    abstract::The goal of this study was to discriminate subtypes of pediatric obsessive-compulsive disorder (OCD) among youth with and without a comorbid tic disorder. Seventy-four youth (M(age)=9.7+/-2.3 years) with a principal diagnosis of OCD, with (n=46) or without (n=28) a comorbid tic disorder, were assessed with a semi-stru...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20304

    authors: Storch EA,Stigge-Kaufman D,Marien WE,Sajid M,Jacob ML,Geffken GR,Goodman WK,Murphy TK

    更新日期:2008-01-01 00:00:00

  • Validity of a simpler definition of major depressive disorder.

    abstract:BACKGROUND:In previous reports from the Rhode Island Methods to Improve Diagnostic Assessment and Services project, we developed a briefer definition of major depressive disorder (MDD), and found high levels of agreement between the simplified and DSM-IV definitions of MDD. The goal of the present study was to examine ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20710

    authors: Zimmerman M,Galione JN,Chelminski I,Young D,Dalrymple K,Witt CF

    更新日期:2010-10-01 00:00:00

  • Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein.

    abstract::Serotonergic (5-hydroxytryptamine; 5-HT) mechanisms have been implicated in a number of physiological and pathophysiological processes including mood, anxiety, and cognitive functioning. Among the many 5-HT receptor subtypes, the 5-HT2A receptors (5-HT2A-R) seem to be of particular importance in mediating these effect...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20087

    authors: Cohen H

    更新日期:2005-01-01 00:00:00

  • Patient-reported outcomes of quality of life, functioning, and depressive symptom severity in major depressive disorder comorbid with panic disorder before and after SSRI treatment in the star*d trial.

    abstract:BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compare...

    journal_title:Depression and anxiety

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/da.22152

    authors: IsHak WW,Mirocha J,Christensen S,Wu F,Kwock R,Behjat J,Pi S,Akopyan A,Peselow ED,Cohen RM,Elashoff D

    更新日期:2014-08-01 00:00:00

  • Periloss dissociation, symptom severity, and treatment response in complicated grief.

    abstract:BACKGROUND:Complicated grief (CG) is a bereavement-specific syndrome characterized by traumatic and separation distress lasting over 6 months. Little is known about the role of dissociation experienced during or immediately after the loss of a loved one (i.e., periloss dissociation [PLD]) in CG. The present study aimed...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22029

    authors: Bui E,Simon NM,Robinaugh DJ,Leblanc NJ,Wang Y,Skritskaya NA,Mauro C,Shear MK

    更新日期:2013-02-01 00:00:00

  • Freezing reaction in panic disorder patients associated with anticipatory anxiety.

    abstract:BACKGROUND:Anticipatory anxiety can be described as a conditioned response with a defensive posture of freezing and autonomic activation. The purpose of this study was to assess the postural control analysis and autonomic activation in panic disorder (PD) patients presented with visual stimuli. METHODS:PD patients (n=...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20593

    authors: Lopes FL,Azevedo TM,Imbiriba LA,Freire RC,Valença AM,Caldirola D,Perna G,Volchan E,Nardi AE

    更新日期:2009-01-01 00:00:00

  • Posttraumatic stress disorder symptom severity is associated with reduced default mode network connectivity in individuals with elevated genetic risk for psychopathology.

    abstract:BACKGROUND:Accumulating evidence suggests that posttraumatic stress disorder (PTSD) is associated with disrupted default mode network (DMN) connectivity, but findings across studies have not been uniform. Individual differences in relevant genes may account for some of the reported variability in the relationship betwe...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22633

    authors: Miller DR,Logue MW,Wolf EJ,Maniates H,Robinson ME,Hayes JP,Stone A,Schichman S,McGlinchey RE,Milberg WP,Miller MW

    更新日期:2017-07-01 00:00:00

  • PTSD REMISSION AFTER PROLONGED EXPOSURE TREATMENT IS ASSOCIATED WITH ANTERIOR CINGULATE CORTEX THINNING AND VOLUME REDUCTION.

    abstract:BACKGROUND:Brain structures underlying posttraumatic stress disorder (PTSD) have been a focus of imaging studies, but associations between treatment outcome and alterations in brain structures remain largely unexamined. We longitudinally examined the relation of structural changes in the rostral anterior cingulate cort...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22471

    authors: Helpman L,Papini S,Chhetry BT,Shvil E,Rubin M,Sullivan GM,Markowitz JC,Mann JJ,Neria Y

    更新日期:2016-05-01 00:00:00

  • The role of values-consistent behavior in generalized anxiety disorder.

    abstract:BACKGROUND:Theory and research suggest that generalized anxiety disorder (GAD) is associated with diminished quality of life and restriction in valued action. The purpose of this study was to examine the relevance of values-consistent behavior (valued action) in understanding the impairment in quality of life in GAD. ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20793

    authors: Michelson SE,Lee JK,Orsillo SM,Roemer L

    更新日期:2011-05-01 00:00:00

  • Sex differences in the use of coping strategies: predictors of anxiety and depressive symptoms.

    abstract::This study examined sex differences in the use of coping strategies and their relationship to depression and anxiety-related psychopathology. Responses on measures of coping strategies, depression, and anxiety were obtained from a carefully screened nonclinical sample (N = 107). The results demonstrated that women who...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20341

    authors: Kelly MM,Tyrka AR,Price LH,Carpenter LL

    更新日期:2008-01-01 00:00:00

  • The bidirectional relationship between anxiety disorders and circulating levels of inflammatory markers: Results from a large longitudinal population-based study.

    abstract:BACKGROUND:Although there has been abundant research on chronic low-grade inflammation as a potential mechanism underlying the link between mood disorders and cardiovascular risk, less is known about the role of inflammatory factors and anxiety disorders. The aim of this paper is to evaluate the bi-directional associat...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22710

    authors: Glaus J,von Känel R,Lasserre AM,Strippoli MF,Vandeleur CL,Castelao E,Gholam-Rezaee M,Marangoni C,Wagner EN,Marques-Vidal P,Waeber G,Vollenweider P,Preisig M,Merikangas KR

    更新日期:2018-04-01 00:00:00

  • Empirically supported psychological treatments for adult acute stress disorder and posttraumatic stress disorder: a review.

    abstract:BACKGROUND:Acute stress disorder (ASD) predicts the development of posttraumatic stress disorder (PTSD), which in some sufferers can persist for years and lead to significant disability. We carried out a review of randomized controlled trials to give an update on which psychological treatments are empirically supported...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20635

    authors: Ponniah K,Hollon SD

    更新日期:2009-01-01 00:00:00

  • Children of low-income depressed mothers: psychiatric disorders and social adjustment.

    abstract:BACKGROUND:Although several studies have documented a higher prevalence of psychiatric disorders in children of depressed than nondepressed parents, previous research was conducted in predominantly White, middle, or upper-middle class populations. Only limited information is available on psychiatric disorders and psych...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20522

    authors: Feder A,Alonso A,Tang M,Liriano W,Warner V,Pilowsky D,Barranco E,Wang Y,Verdeli H,Wickramaratne P,Weissman MM

    更新日期:2009-01-01 00:00:00

  • Symptoms of anxiety in depression: assessment of item performance of the Hamilton Anxiety Rating Scale in patients with depression.

    abstract:BACKGROUND:Although diagnostically dissociable, anxiety is strongly co-morbid with depression. To examine further the clinical symptoms of anxiety in major depressive disorder (MDD), a non-parametric item response analysis on "blinded" data from four pharmaceutical company clinical trials was performed on the Hamilton ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20435

    authors: Vaccarino AL,Evans KR,Sills TL,Kalali AH

    更新日期:2008-01-01 00:00:00

  • Nonverbal memory dysfunction in obsessive-compulsive disorder patients with checking compulsions.

    abstract::Obsessive-compulsive disorder (OCD) is a clinically heterogeneous disorder; nonetheless, most of the previous neuropsychological studies for assessing the involvement of memory dysfunction grouped together patients with different symptoms, thereby potentially accounting for the inconsistencies of results. The goals of...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.20377

    authors: Cha KR,Koo MS,Kim CH,Kim JW,Oh WJ,Suh HS,Lee HS

    更新日期:2008-01-01 00:00:00

  • APPROXIMATING A DSM-5 DIAGNOSIS OF PTSD USING DSM-IV CRITERIA.

    abstract:BACKGROUND:Diagnostic criteria for DSM-5 posttraumatic stress disorder (PTSD) are in many ways similar to DSM-IV criteria, raising the possibility that it might be possible to closely approximate DSM-5 diagnoses using DSM-IV symptoms. If so, the resulting transformation rules could be used to pool research data based o...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22364

    authors: Rosellini AJ,Stein MB,Colpe LJ,Heeringa SG,Petukhova MV,Sampson NA,Schoenbaum M,Ursano RJ,Kessler RC,Army STARRS Collaborators.

    更新日期:2015-07-01 00:00:00

  • Anxiolytic-like effect of group housing on stress-induced behavior in rats.

    abstract::Social support is proposed to attenuate behavioral consequences of exposure to uncontrollable stressors. To test this possibility, we compared the effects of two post-stress housing conditions, in pairs or in groups of 10-12 animals per cage, on the behavior of rats tested in the elevated plus-maze (EPM) 24 hr after s...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.10124

    authors: Andrade CS,Guimarães FS

    更新日期:2003-01-01 00:00:00

  • Classification of trauma and stressor-related disorders in DSM-5.

    abstract::This review examines the question of whether there should be a cluster of disorders, including the adjustment disorders (ADs), acute stress disorder (ASD), posttraumatic stress disorder (PTSD), and the dissociative disorders (DDs), in a section devoted to abnormal responses to stress and trauma in the DSM-5. Environme...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审

    doi:10.1002/da.20845

    authors: Friedman MJ,Resick PA,Bryant RA,Strain J,Horowitz M,Spiegel D

    更新日期:2011-09-01 00:00:00

  • How willing are you? Willingness as a predictor of change during treatment of adults with obsessive-compulsive disorder.

    abstract:OBJECTIVE:Exposure and response prevention (ERP) is an effective treatment for individuals with obsessive-compulsive disorder (OCD), yet a substantial number of individuals with OCD do not fully respond to this intervention. Based on emerging experimental and clinical research on acceptance, this study sought to explor...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22672

    authors: Reid AM,Garner LE,Van Kirk N,Gironda C,Krompinger JW,Brennan BP,Mathes BM,Monaghan SC,Tifft ED,André MC,Cattie J,Crosby JM,Elias JA

    更新日期:2017-11-01 00:00:00

  • Exposure-based therapy changes amygdala and hippocampus resting-state functional connectivity in patients with posttraumatic stress disorder.

    abstract:BACKGROUND:Recent research suggests that posttraumatic stress disorder (PTSD) is associated with altered amygdala and hippocampal resting-state functional connectivity (rsFC). However, less research has examined whether Prolonged Exposure (PE), a first line exposure-based treatment for PTSD, has the potential to alter ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.22816

    authors: Zhu X,Suarez-Jimenez B,Lazarov A,Helpman L,Papini S,Lowell A,Durosky A,Lindquist MA,Markowitz JC,Schneier F,Wager TD,Neria Y

    更新日期:2018-10-01 00:00:00

  • Duration of last depressive episode may influence serum BDNF levels in remitted patients with major depression.

    abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) may have an important role in the pathophysiology of depression. Previous studies indicate that serum BDNF levels were lower in patients with depression and increased after treatment with antidepressants. However, results of studies on serum BDNF levels in remitted pa...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.21933

    authors: Takebayashi N,Maeshima H,Baba H,Nakano Y,Satomura E,Kita Y,Namekawa Y,Nomoto H,Suzuki T,Arai H

    更新日期:2012-09-01 00:00:00

  • Differential neural predictors of treatment response for fear and dysphoric features of posttraumatic stress disorder.

    abstract:BACKGROUND:Although trauma-focused cognitive behavioral therapy (TF-CBT) is the frontline treatment for posttraumatic stress disorder (PTSD), at least one-third of patients are treatment nonresponders. This study aimed to identify neural markers of treatment response, specifically the prediction of remission of specifi...

    journal_title:Depression and anxiety

    pub_type: 杂志文章

    doi:10.1002/da.23061

    authors: Bryant RA,Erlinger M,Felmingham K,Malhi GS,O'Donnell ML,Williams LM,Korgaonkar MS

    更新日期:2020-10-01 00:00:00

  • Difficult-to-treat pediatric obsessive-compulsive disorder: feasibility and preliminary results of a randomized pilot trial of D-cycloserine-augmented behavior therapy.

    abstract:BACKGROUND:This study examined the feasibility and preliminary effectiveness of d-cycloserine (DCS)-augmented cognitive behavioral therapy (CBT) for children and adolescents with difficult-to-treat Obsessive Compulsive Disorder, in a double-blind randomized controlled pilot trial (RCT). METHODS:Seventeen children and ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/da.22132

    authors: Farrell LJ,Waters AM,Boschen MJ,Hattingh L,McConnell H,Milliner EL,Collings N,Zimmer-Gembeck M,Shelton D,Ollendick TH,Testa C,Storch EA

    更新日期:2013-08-01 00:00:00