Transdiagnostic versus diagnosis-specific cbt for anxiety disorders: a preliminary randomized controlled noninferiority trial.


BACKGROUND:Transdiagnostic cognitive-behavioral treatments for anxiety disorders have been gaining increased attention and empirical study in recent years. Despite this, research on transdiagnostic anxiety treatments has, to date, relied on open trials, or comparisons to waitlist conditions, published benchmarks, or relaxation-based interventions. METHODS:The current study was a randomized clinical trial examining the efficacy of a 12-week transdiagnostic cognitive-behavioral group treatment in comparison to 12-week diagnosis-specific group Cognitive-Behavioral Therapy (CBT) protocols for panic disorder, social anxiety disorder, and generalized anxiety disorder. RESULTS:Results from 46 treatment initiators suggested significant improvement during treatment, strong evidence for treatment equivalence across transdiagnostic and diagnosis-specific CBT conditions, and no differences in treatment credibility. CONCLUSIONS:This study provides evidence supporting the efficacy of transdiagnostic CBT by comparison to current gold-standard diagnosis-specific CBT for social anxiety disorder, generalized anxiety disorder, and panic disorder. Transdiagnostic group CBT has the benefit of potentially easing dissemination and increasing access to evidence-based treatments for anxiety without sacrificing efficacy.


Depress Anxiety


Depression and anxiety


Norton PJ,Barrera TL




Has Abstract


2012-10-01 00:00:00












  • Elevated costly avoidance in anxiety disorders: Patients show little downregulation of acquired avoidance in face of competing rewards for approach.

    abstract:BACKGROUND:Pathological avoidance is a transdiagnostic characteristic of anxiety disorders. Avoidance conditioning re-emerged as a translational model to examine mechanisms and treatment of avoidance. However, its validity for anxiety disorders remains unclear. METHODS:This study tested for altered avoidance in patien...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Pittig A,Boschet JM,Glück VM,Schneider K

    更新日期:2020-12-01 00:00:00

  • The effects of latent variables in the development of comorbidity among common mental disorders.

    abstract:BACKGROUND:Although numerous studies have examined the role of latent predispositions to internalizing and externalizing disorders in the structure of comorbidity among common mental disorders, none examined latent predispositions in predicting development of comorbidity. METHODS:A novel method was used to study the r...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Kessler RC,Cox BJ,Green JG,Ormel J,McLaughlin KA,Merikangas KR,Petukhova M,Pine DS,Russo LJ,Swendsen J,Wittchen HU,Zaslavsky AM

    更新日期:2011-01-01 00:00:00

  • Anxiolytic-like effect of group housing on stress-induced behavior in rats.

    abstract::Social support is proposed to attenuate behavioral consequences of exposure to uncontrollable stressors. To test this possibility, we compared the effects of two post-stress housing conditions, in pairs or in groups of 10-12 animals per cage, on the behavior of rats tested in the elevated plus-maze (EPM) 24 hr after s...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Andrade CS,Guimarães FS

    更新日期:2003-01-01 00:00:00

  • Computational model of obsessive-compulsive disorder: examination of etiologic hypothesis and treatment strategies.

    abstract::Research has shown that obsessive compulsive disorder (OCD) is related to structural and functional abnormalities in the brain, and several authors have organized these findings into theories of OCD neuropsychiatric dysfunction. In this paper, these theories were used to develop a neural network model of OCD. OCD symp...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Ownby RL

    更新日期:1998-01-01 00:00:00

  • Social anxiety (phobia) and east Asian culture.

    abstract::Since the introduction of the concept of social anxiety (or phobia) to the American nosological system in DSM-III (1980), it has become increasingly apparent that the condition is also prevalent in other cultures. In Japan, for example, the condition, called taijinkyofusho (usually abbreviated as TKS in English), is w...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审


    authors: Chang SC

    更新日期:1997-01-01 00:00:00

  • Genetics of anxiety disorders: the complex road from DSM to DNA.

    abstract::Anxiety disorders are among the most common psychiatric disorders, affecting one in four individuals over a lifetime. Although our understanding of the etiology of these disorders is incomplete, familial and genetic factors are established risk factors. However, identifying the specific casual genes has been difficult...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审


    authors: Smoller JW,Block SR,Young MM

    更新日期:2009-01-01 00:00:00

  • Predictors of post-traumatic stress disorder following severe injury.

    abstract::The chronicity and morbidity of established post-traumatic stress disorder (PTSD) has stimulated interest in recognizing and understanding the early development of the disorder. Acute stress disorder, a new diagnosis intended to facilitate early case detection, rests on the occurrence of dissociative reactions. It rem...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Mellman TA,David D,Bustamante V,Fins AI,Esposito K

    更新日期:2001-01-01 00:00:00


    abstract:BACKGROUND:Internet-delivered cognitive behavioral therapy (iCBT) is a relatively novel treatment method that may improve the accessibility of mental health care for individuals with posttraumatic stress disorder (PTSD). The aim of this meta-analysis was to evaluate the effectiveness of iCBT compared to inactive (waitl...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,meta分析,评审


    authors: Sijbrandij M,Kunovski I,Cuijpers P

    更新日期:2016-09-01 00:00:00

  • Treatment of severe depression with the selective serotonin reuptake inhibitors.

    abstract::The selective serotonin reuptake inhibitors (SSRIs) are recognized as effective as and better tolerated than older antidepressant therapies and have become the drugs of choice in the treatment of mild to moderate depression. However, there is a clinical impression that the SSRIs are less effective than older therapies...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审


    authors: Schatzberg AF

    更新日期:1996-01-01 00:00:00

  • Cytokine targets in the brain: impact on neurotransmitters and neurocircuits.

    abstract::Increasing attention has been paid to the role of inflammation in a host of illnesses including neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory response leads to release of inflammatory cytokines and mobilization of immune cells both of which have been shown to access the brai...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审


    authors: Miller AH,Haroon E,Raison CL,Felger JC

    更新日期:2013-04-01 00:00:00

  • Extended release quetiapine fumarate in major depressive disorder: analysis in patients with anxious depression.

    abstract:BACKGROUND:A pooled analysis was performed on data from two studies evaluating the efficacy of once-daily extended-release quetiapine fumarate (quetiapine XR) monotherapy for patients with major depressive disorder. Through these analyses (based on Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Thase ME,Demyttenaere K,Earley WR,Gustafsson U,Udd M,Eriksson H

    更新日期:2012-07-01 00:00:00

  • Difficult-to-treat pediatric obsessive-compulsive disorder: feasibility and preliminary results of a randomized pilot trial of D-cycloserine-augmented behavior therapy.

    abstract:BACKGROUND:This study examined the feasibility and preliminary effectiveness of d-cycloserine (DCS)-augmented cognitive behavioral therapy (CBT) for children and adolescents with difficult-to-treat Obsessive Compulsive Disorder, in a double-blind randomized controlled pilot trial (RCT). METHODS:Seventeen children and ...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Farrell LJ,Waters AM,Boschen MJ,Hattingh L,McConnell H,Milliner EL,Collings N,Zimmer-Gembeck M,Shelton D,Ollendick TH,Testa C,Storch EA

    更新日期:2013-08-01 00:00:00

  • Evidence-based psychotherapy trends among posttraumatic stress disorder patients in a national healthcare system, 2001-2014.

    abstract:BACKGROUND:Although evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD) were implemented starting in 2005 in the veterans health administration (VHA), the largest national healthcare system in the U.S., the rate of initiation (uptake) and prevalence of these treatments in each calendar year h...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Maguen S,Holder N,Madden E,Li Y,Seal KH,Neylan TC,Lujan C,Patterson OV,DuVall SL,Shiner B

    更新日期:2020-04-01 00:00:00

  • How willing are you? Willingness as a predictor of change during treatment of adults with obsessive-compulsive disorder.

    abstract:OBJECTIVE:Exposure and response prevention (ERP) is an effective treatment for individuals with obsessive-compulsive disorder (OCD), yet a substantial number of individuals with OCD do not fully respond to this intervention. Based on emerging experimental and clinical research on acceptance, this study sought to explor...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Reid AM,Garner LE,Van Kirk N,Gironda C,Krompinger JW,Brennan BP,Mathes BM,Monaghan SC,Tifft ED,André MC,Cattie J,Crosby JM,Elias JA

    更新日期:2017-11-01 00:00:00

  • Megestrol attenuates the hormonal response to CCK-4-induced panic attacks.

    abstract::Progestational hormones may have anxiolytic properties. CCK-4 (cholecystokinin tetrapeptide) can be used pharmacologically to induce panic attacks both in normal controls and patients suffering from panic disorder. In this study we compared the effects of pretreatment with the progestational hormone megestrol and plac...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Raedler TJ,Jahn H,Goedeken B,Gescher DM,Kellner M,Wiedemann K

    更新日期:2006-01-01 00:00:00

  • Parenting mediates the impact of maternal depression on child internalizing symptoms.

    abstract:BACKGROUND:To examine the potential mediating role of parenting behaviors in the longitudinal, bidirectional relationships between maternal depression and child internalizing symptoms (i.e. depression and anxiety). METHODS:We analyzed data from 4,581 mother-child dyads from the Fragile Families and Child Wellbeing Stu...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Kuckertz JM,Mitchell C,Wiggins JL

    更新日期:2018-01-01 00:00:00

  • The utility of the Generalized Anxiety Disorder Severity Scale (GADSS) with older adults in primary care.

    abstract:BACKGROUND:The Generalized Anxiety Disorder Severity Scale (GADSS) is an interview rating scale designed specifically for assessing symptom severity of generalized anxiety disorder (GAD), which has demonstrated positive psychometric data in a sample of adult primary care patients with GAD and panic disorder. However, t...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Weiss BJ,Calleo J,Rhoades HM,Novy DM,Kunik ME,Lenze EJ,Stanley MA

    更新日期:2009-01-01 00:00:00

  • The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis.

    abstract::Sensitization of stress-responsive neurobiological systems as a possible consequence of early adverse experience has been implicated in the pathophysiology of mood and anxiety disorders. In addition to early adversities, adulthood stressors are also known to precipitate the manifestation of these disorders. The presen...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Heim C,Newport DJ,Wagner D,Wilcox MM,Miller AH,Nemeroff CB

    更新日期:2002-01-01 00:00:00

  • Amygdala-Cortical Connectivity: Associations with Anxiety, Development, and Threat.

    abstract:BACKGROUND:Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, tr...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Gold AL,Shechner T,Farber MJ,Spiro CN,Leibenluft E,Pine DS,Britton JC

    更新日期:2016-10-01 00:00:00

  • Depression and Parkinson's disease: a new look at an old problem.

    abstract::A National Institutes of Health (National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging) working group meeting focused on the non-motor aspects of Parkinson's disease (PD). Below is the summary of the meeting presentations and recommendations for a res...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Edwards E,Kitt C,Oliver E,Finkelstein J,Wagster M,McDonald WM

    更新日期:2002-01-01 00:00:00

  • Sleep, circadian rhythm, and physical activity patterns in depressive and anxiety disorders: A 2-week ambulatory assessment study.

    abstract:BACKGROUND:Actigraphy may provide a more valid assessment of sleep, circadian rhythm (CR), and physical activity (PA) than self-reported questionnaires, but has not been used widely to study the association with depression/anxiety and their clinical characteristics. METHODS:Fourteen-day actigraphy data of 359 particip...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Difrancesco S,Lamers F,Riese H,Merikangas KR,Beekman ATF,van Hemert AM,Schoevers RA,Penninx BWJH

    更新日期:2019-10-01 00:00:00

  • Empirically supported psychological treatments for adult acute stress disorder and posttraumatic stress disorder: a review.

    abstract:BACKGROUND:Acute stress disorder (ASD) predicts the development of posttraumatic stress disorder (PTSD), which in some sufferers can persist for years and lead to significant disability. We carried out a review of randomized controlled trials to give an update on which psychological treatments are empirically supported...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,评审


    authors: Ponniah K,Hollon SD

    更新日期:2009-01-01 00:00:00

  • Cognitive-behavioral group therapy versus group psychotherapy for social anxiety disorder among college students: a randomized controlled trial.

    abstract:OBJECTIVE:In this randomized controlled trial, cognitive-behavioral group therapy (CBGT) for social anxiety disorder (SAD) was compared to group psychotherapy (GPT), a credible, structurally equivalent control condition that included only nonspecific factors of group treatment (such as group dynamics). METHODS:Partici...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Bjornsson AS,Bidwell LC,Brosse AL,Carey G,Hauser M,Mackiewicz Seghete KL,Schulz-Heik RJ,Weatherley D,Erwin BA,Craighead WE

    更新日期:2011-11-01 00:00:00

  • Psychological resilience in older U.S. veterans: results from the national health and resilience in veterans study.

    abstract:BACKGROUND:Although a large body of empirical research has examined negative psychological outcomes in older veterans, relatively little is known about the prevalence and determinants of psychological resilience in this population. METHODS:A nationally representative sample of 2,025 U.S. veterans aged 60 and older (me...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Pietrzak RH,Cook JM

    更新日期:2013-05-01 00:00:00

  • Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication?

    abstract::Participants with generalized social phobia (GSP) with (n=36) and without (n=19) avoidant personality disorder (AVPD) were compared via contrasts of group means and classification analysis on purported core features of AVPD. GSP-AVPD participants proved to be more severely impaired or distressed on some group contrast...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Chambless DL,Fydrich T,Rodebaugh TL

    更新日期:2008-01-01 00:00:00

  • Associations between socioeconomic status and psychological therapy outcomes: A systematic review and meta-analysis.

    abstract:BACKGROUND:Socioeconomic deprivation is associated with higher prevalence of mental health problems; however, the influence of socioeconomic status (SES) on psychological therapy outcomes is as yet unclear. AIM:To review published evidence on the association between indicators of SES (income, education, employment, ne...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,meta分析,评审


    authors: Finegan M,Firth N,Wojnarowski C,Delgadillo J

    更新日期:2018-06-01 00:00:00

  • The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial.

    abstract:OBJECTIVES:To explore the anxiolytic effects of a 4-month randomized, placebo-controlled trial of exercise and antidepressant medication in patients with major depressive disorder (MDD), and to examine the potential modifying effects of anxiety in treating depressive symptoms. MATERIALS AND METHODS:In this secondary a...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Blumenthal JA,Babyak MA,Craighead WE,Davidson J,Hinderliter A,Hoffman B,Doraiswamy PM,Sherwood A

    更新日期:2020-08-12 00:00:00

  • Pharmacological treatment of social anxiety disorder: a meta-analysis.

    abstract::Placebo-controlled trials have evaluated the efficacy of several medications in the treatment of social anxiety disorder but information regarding their relative efficacy is lacking. We compared the efficacy of medications systematically studied for the treatment of social anxiety disorder using meta-analytic techniqu...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,meta分析


    authors: Blanco C,Schneier FR,Schmidt A,Blanco-Jerez CR,Marshall RD,Sánchez-Lacay A,Liebowitz MR

    更新日期:2003-01-01 00:00:00

  • Complicated grief associated with hurricane Katrina.

    abstract:BACKGROUND:Although losses are important consequences of disasters, few epidemiological studies of disasters have assessed complicated grief (CG) and none assessed CG associated with losses other than death of loved one. METHODS:Data come from the baseline survey of the Hurricane Katrina Community Advisory Group, a re...

    journal_title:Depression and anxiety

    pub_type: 杂志文章


    authors: Shear MK,McLaughlin KA,Ghesquiere A,Gruber MJ,Sampson NA,Kessler RC

    更新日期:2011-08-01 00:00:00

  • Unguided Internet-based cognitive-behavioral therapy for obsessive-compulsive disorder: A randomized controlled trial.

    abstract:BACKGROUND:Many individuals with obsessive-compulsive disorder (OCD) do not receive professional treatment due to various idiosyncratic barriers. Internet-based cognitive-behavioral therapy (iCBT) is increasingly used to narrow treatment gaps, but the efficacy of such interventions without guidance of therapists has no...

    journal_title:Depression and anxiety

    pub_type: 杂志文章,随机对照试验


    authors: Schröder J,Werkle N,Cludius B,Jelinek L,Moritz S,Westermann S

    更新日期:2020-12-01 00:00:00