Abstract:
BACKGROUND:Physical activity is increasingly recognized as an important modifiable factor for depression. However, the extent to which individuals with stable risk factors for depression, such as high genetic vulnerability, can benefit from the protective effects of physical activity, remains unknown. Using a longitudinal biobank cohort integrating genomic data from 7,968 individuals of European ancestry with high-dimensional electronic health records and lifestyle survey responses, we examined whether physical activity was prospectively associated with reduced risk for incident depression in the context of genetic vulnerability. METHODS:We identified individuals with incident episodes of depression, based on two or more diagnostic billing codes for a depressive disorder within 2 years following their lifestyle survey, and no such codes in the year prior. Polygenic risk scores were derived based on large-scale genome-wide association results for major depression. We tested main effects of physical activity and polygenic risk scores on incident depression, and effects of physical activity within stratified groups of polygenic risk. RESULTS:Polygenic risk was associated with increased odds of incident depression, and physical activity showed a protective effect of similar but opposite magnitude, even after adjusting for BMI, employment status, educational attainment, and prior depression. Higher levels of physical activity were associated with reduced odds of incident depression across all levels of genetic vulnerability, even among individuals at highest polygenic risk. CONCLUSIONS:Real-world data from a large healthcare system suggest that individuals with high genetic vulnerability are more likely to avoid incident episodes of depression if they are physically active.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Choi KW,Zheutlin AB,Karlson RA,Wang MJ,Dunn EC,Stein MB,Karlson EW,Smoller JWdoi
10.1002/da.22967subject
Has Abstractpub_date
2020-02-01 00:00:00pages
106-114issue
2eissn
1091-4269issn
1520-6394journal_volume
37pub_type
杂志文章abstract::This study was designed to investigate the efficacy of the antidepressant fluvoxamine in the treatment of combat-related post-traumatic stress disorder (PTSD). Fifteen veterans with combat-related PTSD and no other psychiatric diagnosis except depression were recruited to participate in a 14-week open-label study of f...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
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更新日期:2002-01-01 00:00:00
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journal_title:Depression and anxiety
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abstract:BACKGROUND:Whether psychological resilience correlates with neurocognitive performance is largely unknown. Therefore, we assessed association between neurocognitive performance and resilience in individuals with a history of childhood abuse or trauma exposure. METHODS:In this cross-sectional study of 226 highly trauma...
journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20580
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the prospective relationship between a history of attention-deficit/hyperactivity disorder (ADHD) assessed in mid-adolescence and the onset of major depressive disorder (MDD) through early adulthood in a large school-based sample. A secondary aim was to examine whether th...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22082
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journal_title:Depression and anxiety
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doi:10.1002/da.20715
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22331
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.1066
更新日期:2001-01-01 00:00:00
abstract::This study provides a focused review of issues that are relevant to the nosology of the tic disorders and presents preliminary recommendations to be considered for DSM-V. The recommended changes are designed to clarify and simplify the diagnostic criteria, reduce the use of the residual category, tic disorder not othe...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20711
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22932
更新日期:2019-09-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20303
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is a heterogeneous condition, which can be expressed as various potentially overlapping symptom dimensions. In clinical samples, some of these dimensions are associated with increased familial risk for OCD and appear to be familial (intercorrelated within pairs of affected...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20606
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) has been associated with changes in mean telomere length and mitochondrial DNA (mtDNA) copy number. This study investigates if clinical features of MDD differentially impact these molecular markers. METHODS:Data from a large, clinically ascertained sample of Han Chinese women...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22517
更新日期:2016-11-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/da.22273
更新日期:2014-05-01 00:00:00
abstract::Participants with generalized social phobia (GSP) with (n=36) and without (n=19) avoidant personality disorder (AVPD) were compared via contrasts of group means and classification analysis on purported core features of AVPD. GSP-AVPD participants proved to be more severely impaired or distressed on some group contrast...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20266
更新日期:2008-01-01 00:00:00
abstract::Despite emotion regulation being altered in patients with obsessive-compulsive disorder (OCD), no studies have investigated its relation to multimodal amygdala connectivity. We compared corticolimbic functional and structural connectivity between OCD patients and healthy controls (HCs), and correlated this with the di...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22845
更新日期:2019-02-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20001
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The Generalized Anxiety Disorder Severity Scale (GADSS) is an interview rating scale designed specifically for assessing symptom severity of generalized anxiety disorder (GAD), which has demonstrated positive psychometric data in a sample of adult primary care patients with GAD and panic disorder. However, t...
journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.20520
更新日期:2009-01-01 00:00:00
abstract::In this analysis we examined studies of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) to compare efficacy and drop-out rates. Frequency of reported side effects was also studied. Using Medline, we located 36 clinical trials of TCAs and SSRIs in a double-blind comparison. We perfo...
journal_title:Depression and anxiety
pub_type: 杂志文章,meta分析
doi:10.1002/(sici)1520-6394(1997)6:1<10::aid-da2>3.0.c
更新日期:1997-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.1044
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journal_title:Depression and anxiety
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更新日期:2016-10-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.22224
更新日期:2014-04-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20636
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Acute stress disorder (ASD) predicts the development of posttraumatic stress disorder (PTSD), which in some sufferers can persist for years and lead to significant disability. We carried out a review of randomized controlled trials to give an update on which psychological treatments are empirically supported...
journal_title:Depression and anxiety
pub_type: 杂志文章,评审
doi:10.1002/da.20635
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20423
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20366
更新日期:2008-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22481
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:The role of the neuropeptide oxytocin (OT) in Borderline Personality Disorder (BPD) is poorly understood. It is particularly unknown how early experiences with caregivers moderate the action of OT in BPD. Here, we examined the association of plasma OT levels in BPD patients with the experience of c...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22683
更新日期:2018-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22394
更新日期:2015-10-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22633
更新日期:2017-07-01 00:00:00