Are obsessive-compulsive symptom dimensions familial in nonclinical individuals?

abstract：:We report the case of adolescent male with obsessive-compulsive disorder (OCD) who had an incomplete response to combined cognitive-behavioral therapy (CBT) and sertraline before successful augmentation of CBT with aripiprazole. Standardized assessments indicated significant reductions in OCD symptomatology associated...

journal_title：Depression and anxiety

authors： Storch EA,Lehmkuhl H,Geffken GR,Touchton A,Murphy TK

更新日期：2008-01-01 00:00:00

abstract：:We examined the personality characteristics of depressed patients with and without atypical depression. Of 195 depressed outpatients in a randomized treatment trial of fluoxetine or nortriptyline, 16 met DSM-IV criteria for atypical depression. We compared the personality traits and disorders in those with and without...

journal_title：Depression and anxiety

authors： Joyce PR,Mulder RT,McKenzie JM,Luty SE,Cloninger CR

更新日期：2004-01-01 00:00:00

abstract：:Sleep deprivation for one night has been investigated as a treatment for depression since the first publications describing its antidepressant properties almost 30 years ago [Pflug and Tolle, 1971: Int Pharmacopsychiatry 6:187-196]. It remains a field of active research. It is the only intervention consistently demons...

journal_title：Depression and anxiety

authors： Ringel BL,Szuba MP

更新日期：2001-01-01 00:00:00

abstract：:Data from early studies of selective serotonin reuptake inhibitors have shown that these agents are effective in the treatment of social anxiety disorder (social phobia). This review highlights the outcomes of three large clinical trials of paroxetine in patients with social anxiety disorder. In two of the studies, pa...

journal_title：Depression and anxiety

authors： Lydiard RB,Bobes J

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Increased psychophysiological reactivity is a hallmark intermediate phenotype of posttraumatic stress disorder (PTSD). Individuals with PTSD exhibit greater skin conductance (SC) responses to trauma scripts than trauma survivors without PTSD. However, trauma scripts require time for development and cannot be...

journal_title：Depression and anxiety

authors： Hinrichs R,Michopoulos V,Winters S,Rothbaum AO,Rothbaum BO,Ressler KJ,Jovanovic T

更新日期：2017-06-01 00:00:00

abstract：:This study aimed to assess the effects of anisomycin, a protein synthesis inhibitor, on behavioral responses, brain-derived neurotrophic factor (BDNF) and TrkB mRNA levels, and circulating corticosterone in rats-when administered before or after initial exposure to a predator scent stress stimulus. Magnitude of change...

journal_title：Depression and anxiety

authors： Kozlovsky N,Kaplan Z,Zohar J,Matar MA,Shimon H,Cohen H

更新日期：2008-01-01 00:00:00

abstract：:This study used an open clinical trial to test a cognitive-behavioral treatment for public-speaking anxiety that utilized virtual reality as a tool for exposure therapy. Treatment was completed by participants (n = 10) meeting the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria for social phobi...

journal_title：Depression and anxiety

authors： Anderson PL,Zimand E,Hodges LF,Rothbaum BO

更新日期：2005-01-01 00:00:00

abstract：:The objective of the study is to evaluate the quality of web-based information on social phobia and to investigate particular quality indicators. Two keywords, "Social phobia" and "Social Anxiety Disorder", were entered into five popular World Wide Web search engines. Websites were assessed with a standardized proform...

journal_title：Depression and anxiety

authors： Khazaal Y,Fernandez S,Cochand S,Reboh I,Zullino D

更新日期：2008-01-01 00:00:00

abstract：:Numerous studies have examined the acute antidepressant effects of prefrontal transcranial magnetic stimulation (TMS). However, there is little information on whether TMS can be used as a maintenance treatment to maintain normal mood once subjects have responded. We describe seven adults with bipolar depression who re...

journal_title：Depression and anxiety

authors： Li X,Nahas Z,Anderson B,Kozel FA,George MS

更新日期：2004-01-01 00:00:00

abstract：:The use of a placebo run-in phase, in which placebo responders are withdrawn from a study before random assignment to treatment condition, has been criticized as favoring the active treatment in clinical trials. We compared the effect size of randomized, placebo-controlled clinical trials (in the treatment of depressi...

journal_title：Depression and anxiety

authors： Lee S,Walker JR,Jakul L,Sexton K

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compare...

journal_title：Depression and anxiety

authors： IsHak WW,Mirocha J,Christensen S,Wu F,Kwock R,Behjat J,Pi S,Akopyan A,Peselow ED,Cohen RM,Elashoff D

更新日期：2014-08-01 00:00:00

abstract：:The P1 midlatency auditory evoked potential was studied in female rape victims with Posttraumatic Stress Disorder (PTSD) and compared to an age-matched female control group; and in male combat veterans with PTSD and compared to three groups of age-matched male control subjects. Sensory gating of the P1 potential was d...

journal_title：Depression and anxiety

authors： Skinner RD,Rasco LM,Fitzgerald J,Karson CN,Matthew M,Williams DK,Garcia-Rill E

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To compare the rates of low birth weight, preterm delivery and small for gestational age (SGA), in pregnancy outcomes among women who were exposed and nonexposed to antidepressants during pregnancy. METHODS:At The Motherisk Program, we analyzed pregnancy outcomes of 1,243 women in our database who took vario...

journal_title：Depression and anxiety

authors： Einarson A,Choi J,Einarson TR,Koren G

更新日期：2010-01-01 00:00:00

abstract：:Reports on the severity and reversibility of cognitive disturbances in major depression in the literature diverge due to methodological biases. The present study, using a precise methodology, examined attention and executive functions in 20 relatively young, depressed patients presenting a first or second episode of u...

journal_title：Depression and anxiety

authors： Constant EL,Adam S,Gillain B,Seron X,Bruyer R,Seghers A

更新日期：2005-01-01 00:00:00

abstract：:Dopamine D(2) receptor availability in the striatum has been reported to be low in generalized social anxiety disorder (GSAD) and obsessive-compulsive disorder (OCD), but it has not been studied in persons with comorbid OCD and GSAD (OCD+GSAD). D(2) receptor availability was assessed in 7 subjects with OCD+GSAD, 8 wit...

journal_title：Depression and anxiety

authors： Schneier FR,Martinez D,Abi-Dargham A,Zea-Ponce Y,Simpson HB,Liebowitz MR,Laruelle M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Fear overgeneralization is a central feature of anxiety disorders and can lead to excessive avoidance. As perceptual discrimination is a key component of fear overgeneralization, a perceptual discrimination training task was created aimed at improving perceptual discrimination and reducing fear overgeneraliz...

journal_title：Depression and anxiety

authors： Ginat-Frolich R,Klein Z,Aderka IM,Shechner T

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the rela...

journal_title：Depression and anxiety

authors： Ball TM,Knapp SE,Paulus MP,Stein MB

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Previous studies have indicated a high prevalence of generalized anxiety disorder (GAD) in women with anorexia nervosa (AN). However, the shared genetic and environmental components of these disorders have not been explored. This study seeks to elucidate the shared genetic and environmental components betwee...

journal_title：Depression and anxiety

authors： Dellava JE,Kendler KS,Neale MC

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Comorbid psychiatric disorders, cardiovascular disease, chronic hypertension, diabetes, and musculoskeletal disorders are highly prevalent in depression. However, the extent to which these conditions affect the recurrence of depression-related work disability is unknown. The specific aims of the study were t...

journal_title：Depression and anxiety

authors： Ervasti J,Vahtera J,Pentti J,Oksanen T,Ahola K,Kivekäs T,Kivimäki M,Virtanen M

更新日期：2014-09-01 00:00:00

abstract：:Treatment-resistant depression (TRD) in adolescents is prevalent and impairing. We here review the definition, prevalence, clinical significance, risk factors, and management of TRD in adolescents. Risk factors associated with TRD include characteristics of depression (severity, level of hopelessness, and suicidal ide...

journal_title：Depression and anxiety

authors： Maalouf FT,Atwi M,Brent DA

更新日期：2011-11-01 00:00:00

abstract：:This study explores the psychometric properties of the Portuguese version of Corah's Dental Anxiety Scale (DAS), an instrument designed to assess the manifestations of dental anxiety. The DAS has been translated into several languages, but no adaptation and reliability analysis of the Portuguese version of the scale h...

journal_title：Depression and anxiety

authors： Hu LW,Gorenstein C,Fuentes D

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Recent research suggests that posttraumatic stress disorder (PTSD) is associated with altered amygdala and hippocampal resting-state functional connectivity (rsFC). However, less research has examined whether Prolonged Exposure (PE), a first line exposure-based treatment for PTSD, has the potential to alter ...

journal_title：Depression and anxiety

authors： Zhu X,Suarez-Jimenez B,Lazarov A,Helpman L,Papini S,Lowell A,Durosky A,Lindquist MA,Markowitz JC,Schneier F,Wager TD,Neria Y

更新日期：2018-10-01 00:00:00

abstract：:In spite of substantial advances in the treatment of major depression by pharmacotherapy and other means, a significant number of depressed patients require hospitalization. In the context of the Jerusalem Collaborative Depression Project, possible precipitants of psychiatric hospitalization were sought in a cohort of...

journal_title：Depression and anxiety

authors： Lerer B,Shapira B,Bloch M,Hanin B,Trudart T,Alexander JR,Popper M,Braun D,Segman RH,Ritsner M

更新日期：1999-01-01 00:00:00

abstract：:In this analysis we examined studies of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) to compare efficacy and drop-out rates. Frequency of reported side effects was also studied. Using Medline, we located 36 clinical trials of TCAs and SSRIs in a double-blind comparison. We perfo...

journal_title：Depression and anxiety

authors： Steffens DC,Krishnan KR,Helms MJ

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Socioeconomic deprivation is associated with higher prevalence of mental health problems; however, the influence of socioeconomic status (SES) on psychological therapy outcomes is as yet unclear. AIM:To review published evidence on the association between indicators of SES (income, education, employment, ne...

journal_title：Depression and anxiety

authors： Finegan M,Firth N,Wojnarowski C,Delgadillo J

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Major depressive disorder (MDD) has been associated with changes in mean telomere length and mitochondrial DNA (mtDNA) copy number. This study investigates if clinical features of MDD differentially impact these molecular markers. METHODS:Data from a large, clinically ascertained sample of Han Chinese women...

journal_title：Depression and anxiety

authors： Edwards AC,Aggen SH,Cai N,Bigdeli TB,Peterson RE,Docherty AR,Webb BT,Bacanu SA,Flint J,Kendler KS

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Although several studies have documented a higher prevalence of psychiatric disorders in children of depressed than nondepressed parents, previous research was conducted in predominantly White, middle, or upper-middle class populations. Only limited information is available on psychiatric disorders and psych...

journal_title：Depression and anxiety

authors： Feder A,Alonso A,Tang M,Liriano W,Warner V,Pilowsky D,Barranco E,Wang Y,Verdeli H,Wickramaratne P,Weissman MM

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Synchronized transcranial magnetic stimulation (sTMS) is a new modality to reduce symptoms of major depressive disorder (MDD). sTMS uses rotating neodymium magnets to deliver low-field stimulation matched to the individual alpha frequency (IAF). A previous multisite study showed that sTMS significantly reduc...

journal_title：Depression and anxiety

authors： Philip NS,Leuchter AF,Cook IA,Massaro J,Goethe JW,Carpenter LL

更新日期：2019-03-01 00:00:00

abstract：:Pramipexole, a dopamine D2 receptor agonist, was tested in 174 patients with major depression, with or without melancholia and without psychotic features. Three daily dose levels (0.375 mg, 1.0 mg, and 5.0 mg) were compared to fluoxetine (Prozac) at 20 mg and placebo in a randomized, double-blind, parallel-group study...

journal_title：Depression and anxiety

authors： Corrigan MH,Denahan AQ,Wright CE,Ragual RJ,Evans DL

更新日期：2000-01-01 00:00:00

abstract：:Our objective was to evaluate parental risk factors for pediatric-onset panic disorder/agoraphobia (PD/AG) in offspring at high risk for PD/AG. Comparisons were made between parents with PD who had a child with PD or AG (N = 27) and parents with PD without children with PD or AG (N = 79). Comparisons were also made be...

journal_title：Depression and anxiety

authors： Biederman J,Petty C,Faraone SV,Hirshfeld-Becker DR,Henin A,Dougherty M,Lebel TJ,Pollack M,Rosenbaum JF

更新日期：2005-01-01 00:00:00