Abstract：
:Clinical data from 120 adult patients with genetically undifferentiated polycystic kidney disease who had been followed up for more than 3 months (range 3-172) were reviewed in order to try to identify clinical indicators that might predict deterioration in renal function. They were split into two groups dependent on whether annualized fall in estimated glomerular filtration rate (ΔeGFR mL/min/1.73 m(2) /year) was statistically significant or not. Only 26 patients (22%) had a statistically significantly decreasing ΔeGFR with a median decrease of -2.6 mL/min/1.73 m(2) /year (range -6.2 to -0.7). There was no difference in initial age, gender, or racial distributions between the groups or in initial eGFR. Follow-up was longer (median 86, range 23-172 months vs. 46, range 3-161 months; P = 0.002) and initial blood pressure values tended to be lower (with mean systolic values of 128 vs. 148 mm Hg; P = 0.02) in the group with statistically significant fall in ΔeGFR, but this trend failed to achieve an a priori level of statistical significance. However, the proportion of patients with initial systolic blood pressure ≤ 144 developing a statistically significant fall in ΔeGFR was 0.26 (95% confidence interval = 0.13 to 0.45). No differences were found in initial hemoglobin or cholesterol concentrations. Overall, the annualized rate of decrease in eGFR tended to be greater in those with the higher initial eGFR (P = 0.04), but correlation was poor (rho(2) = 0.04) and failed to achieve an a priori level of statistical significance. No statistically significant correlation was found between ΔeGFR and any other variable. Only those patients with polycystic kidney disease with a statistically significant annualized decrease in eGFR may need to be referred for hospital follow-up in the renal clinic. This simple selection would reduce referrals by 78%.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Griveas I,Bishop K,World Mdoi
10.1111/j.1525-1594.2012.01441.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
594-9issue
7eissn
0160-564Xissn
1525-1594journal_volume
36pub_type
杂志文章abstract：:Renal Solutions Allient Sorbent Hemodialysis System utilizes a two-chambered pneumatic pump (Pulsar Blood Pump, Renal Solutions, Inc., Warrendale, PA, USA) to avoid limitations associated with peristaltic pumping systems. Single-needle access is enabled by counter-pulsing the two pump chambers, thereby obviating compl...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00724.x
更新日期：2009-04-01 00:00:00
abstract：:Different methods are used, clinically and experimentally, to assist severely impaired heart function by means of skeletal muscle. The efficiency of these methods is restricted by skeletal muscle losing strength after transpositioning and during conditioning and not being sufficiently resistant to fatigue. This is mai...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1999.06258.x
更新日期：1999-04-01 00:00:00
abstract：:The rotary blood pump will be an implantable left ventricular assist device (LVAD) in the near future. However, the best control method and the interrelationship between the rotary blood pump and native heart functions are unclear. An estimation was made of the native heart cardiac output from the change of an LVAD's ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1998.06127.x
更新日期：1998-05-01 00:00:00
abstract：:Tissue-engineered heart valves constructed from a xenogeneic or allogeneic decellularized matrix might overcome the disadvantages of current heart valve substitutes. One major necessity besides effective decellularization is to preserve the biomechanical properties of the valve. Native and decellularized porcine pulmo...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2007.00452.x
更新日期：2008-01-01 00:00:00
abstract：:The determination of when to stop extracorporeal membrane oxygenation (ECMO) rests upon demonstration of the return of adequate cardiac function to support vital organs and permit subsequent recovery. In general, patients with myocardial stun will recover function within several days. Factors that limit recovery inclu...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1999.06445.x
更新日期：1999-11-01 00:00:00
abstract：:Patients with kidney failure can only survive with some form of kidney replacement (transplant or dialysis). Unfortunately, innovations in kidney replacement therapy lag behind many other medical fields. This study compiles expert opinions on candidate technologies for future kidney replacement therapies. A worldwide ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13784
更新日期：2020-07-22 00:00:00
abstract：:In a typical open-heart surgery, the blood flow through the aortic cannula is a critical element of the cardiopulmonary bypass (CPB) procedure. Especially for the neonatal and pediatric CPB flow conditions, the need for small hydraulic diameter and large blood flow results confined turbulent jet flow regimes that exac...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13462
更新日期：2019-10-01 00:00:00
abstract：:The major problems with existing centrifugal pumps are leakage, mechanical trauma, and thrombus formation. In consideration of these problems, a new compact centrifugal pump system was developed. The purpose of this study was to evaluate the new centrifugal pump system clinically. Ten patients underwent open heart sur...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1994.tb03403.x
更新日期：1994-09-01 00:00:00
abstract：:We developed a novel miniaturized extracorporeal centrifugal pump "BIOFLOAT NCVC (Nipro Corporation Osaka, Japan) as a ventricular assist device (VAD) and performed a preclinical study that is part of the process for its approval as a bridge to decision by the pharmaceutical and medical device agencies. The aim of thi...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13459
更新日期：2019-09-01 00:00:00
abstract：:The PI3K/Akt signaling pathway has been implicated in playing an important role in platelet activation during hemostasis and thrombosis involving platelet-matrix interaction and platelet aggregation. Its role in non-physiological shear stress (NPSS)-induced platelet activation relevant to high-shear blood contacting m...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.13465
更新日期：2019-09-01 00:00:00
abstract：:Albumin-coated Amberlite XAD-7 has been previously shown to be blood compatible in in vitro hemoperfusion experiments whith human blood. In this study, the preliminary results are reported on single hemoperfusions with albumin-coated XAD-7 resin in four patients with acute liver failure. The mean platelet count was 11...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1979.tb03800.x
更新日期：1979-02-01 00:00:00
abstract：:To analyze the autonomic nervous system during left heart bypass with a vibrating flow pump (VFP), fluctuations in hemodynamic derivatives were evaluated by the spectral analysis method using fast fourier transform methodology. After the left pleural cavity was opened through the fourth intercostal space under general...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:Experiments have been successfully performed culminating in functional, vascularized, three-dimensional cardiac muscle tissue. Past experience in tissue engineering has led us to the understanding that cell seeding density plays a critical role in the formation and function of both in vitro and in vivo engineered tiss...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2008.00591.x
更新日期：2008-09-01 00:00:00
abstract：:As a preliminary investigation to establish a cryopreservation method suited for bioartificial livers (BALs), three-dimensional (3-D) cryopreservation experiments with fibroblasts were performed, in which the cells were firstly seeded into a porous scaffold, and the scaffold containing the cells was then cryopreserved...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2009.00933.x
更新日期：2010-07-01 00:00:00
abstract：:Excessive left ventricular (LV) volume unloading can affect right ventricular (RV) function by causing a leftward shift of the interventricular septum in patients with mitral regurgitation (MR) receiving left ventricular assist device (LVAD) support. Optimal settings for the LVAD should be chosen to appropriately cont...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12702
更新日期：2016-11-01 00:00:00
abstract：:Early in 1956, the first model of a biological artificial liver, using a live dog's liver incorporated in a cross-hemodialyzer, was placed in an experimental animal with portocaval encephalopathy. This "biological artificial liver," a hybrid artificial liver in the present terminology, was the first in the world. In O...
journal_title：Artificial organs
pub_type： 历史文章,杂志文章
doi：10.1111/j.1525-1594.1986.tb02548.x
更新日期：1986-06-01 00:00:00
abstract：:A galactosamine-induced fulminant hepatic failure (FHF) rat model was used to study the effects of homologous cross-circulation and in situ liver perfusion. Cross-circulation with homologous donors did not significantly improve the survival time or recovery rate of grade II hepatic coma rats. Homologous in situ liver ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1980.tb03929.x
更新日期：1980-08-01 00:00:00
abstract：:This study assessed the efficacy of multiarterial bypass in coronary artery bypass grafting (CABG) in dialysis patients. Eighty dialysis patients who underwent CABG were divided into 2 groups. Group A consisted of 38 patients in whom the left internal thoracic artery and additional saphenous vein graft (SVG) had been ...
journal_title：Artificial organs
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:Widespread use of heart transplantation is limited by the scarcity of donor organs. Total artificial heart (TAH) development has been pursued to address this shortage, especially to treat patients who require biventricular support. We have developed a novel TAH that utilizes a continuously spinning rotor that shuttles...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/aor.12959
更新日期：2017-10-01 00:00:00
abstract：:The sensitivity of liver allografts to even minimal periods of ischemia currently limits the duration of hepatic preservation prior to liver transplantation. This study evaluates the role of activated carbon hemoperfusion (ACH) for assisting the recovery of canine livers ischemically damaged by a 20-min occlusion of t...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1985.tb04386.x
更新日期：1985-08-01 00:00:00
abstract：:To study the microvessels in bulbar conjunctiva, we conducted an experiment in goat with a pneumatically driven left heart bypass pump, which was replaced with an undulation pump-left ventricle assist device for 9 days. Three flow patterns were tested: complete pulsatile, continuous, and percentage of pulsatile. We st...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.2006.00244.x
更新日期：2006-06-01 00:00:00
abstract：:The objective of this study was to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of two pediatric oxygenators in a simulated pediatric cardiopulmonary bypass (CPB) model and the importance of adding an arterial filter in the circuit. The circuit consisted of a Braile Infant oxygen...
journal_title：Artificial organs
pub_type： 杂志文章,多中心研究
doi：10.1111/aor.12912
更新日期：2017-09-01 00:00:00
abstract：:Four hundred and forty-two serum ferritin determinations were performed in 144 patients on chronic intermittent hemodialysis treatment with intravenous iron substitution and/or oral iron substitution. Iron substitution should be done individually according to regular serum ferritin determinations. Intravenous iron sub...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1981.tb03980.x
更新日期：1981-05-01 00:00:00
abstract：:Individualized short hemodialysis treatment schedules, approximately three 3-h treatments per week, were introduced in a nephrology unit in 1976. In May 1985, 259 patients had been treated, which corresponds to approximately 60 new patients per million inhabitants per year. Ages at start of therapy ranged between 17 a...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1986.tb02541.x
更新日期：1986-06-01 00:00:00
abstract：:The clearance characteristics of two sizes of hemodialyzers (0.9 m2 and 1.5 m2) from the same range of products have been studied over the dialysate flow range of 500-3,000 ml/min to establish the device's overall mass transfer resistance characteristics. The results obtained demonstrate a difference in the overall ma...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1111/j.1525-1594.1995.tb02279.x
更新日期：1995-11-01 00:00:00
abstract：:A rise in intracellular calcium concentration in erythrocytes has multiple effects on these cells. The purpose of this study was to determine the changes of calcium content in red blood cells (RBCs) and of echinocyte percentages in uremic patients during hemodialysis sessions. In 30 uremic patients under hemodialysis,...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2001.025006486.x
更新日期：2001-06-01 00:00:00
abstract：:We tried to verify the hypothesis that increases in pump flow during diastole are matched by decreases in left ventricular (LV) output during systole. A calf (80 kg) was implanted with an implantable centrifugal blood pump (EVAHEART, SunMedical Technology Research Corp., Nagano, Japan) with left ventricle to aorta (LV...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.2001.06864.x
更新日期：2001-09-01 00:00:00
abstract：:In this study, a detection algorithm for suction and regurgitation of the centrifugal pump during left heart bypass without relying on external flow or pressure sensors was developed and evaluated in acute studies using adult goats. The detection scheme relies on power spectral density (PSD) analysis of the motor curr...
journal_title：Artificial organs
pub_type： 杂志文章
doi：10.1046/j.1525-1594.1999.06397.x
更新日期：1999-06-01 00:00:00
abstract：:In total, 30 patients suffering from familial hypercholesterolemia, resistant to diet and lipid-lowering drugs, were treated for up to 6 years (3.6 + or - 1.6; range, 0.2-6.8 years) with low-density lipoprotein (LDL) apheresis. Three different systems were used; the dextran sulfate adsorption system (Kaneka) for 27 of...
journal_title：Artificial organs
pub_type： 临床试验,杂志文章
doi：10.1111/j.1525-1594.1996.tb04455.x
更新日期：1996-04-01 00:00:00
abstract：:Technological innovations in pediatric extracorporeal life support circuits can reduce system-related complications and may improve patients' outcome. The Deltastream DP3 (Medos Medizintechnik AG, Stolberg, Germany) is a novel rotational pump with a diagonally streamed impeller that can be used over a broad range of f...
journal_title：Artificial organs
pub_type： 杂志文章,多中心研究
doi：10.1111/aor.13016
更新日期：2018-04-01 00:00:00
