Clinical evaluation of a new type of centrifugal pump.


:The major problems with existing centrifugal pumps are leakage, mechanical trauma, and thrombus formation. In consideration of these problems, a new compact centrifugal pump system was developed. The purpose of this study was to evaluate the new centrifugal pump system clinically. Ten patients underwent open heart surgery with a centrifugal pump or a roller pump. During surgery, hemodynamic and hematological data were obtained. A pulsatile assist device in the pump circuit was used in patients with severe heart disease. There was neither operative death nor hospital mortality, and there was no difference with regard to hemodynamic data between the two groups. The centrifugal pump groups, however, had significantly lower hemolysis, especially during prolonged cardiopulmonary bypass. This centrifugal pump could also create sufficient pulsatile flow with a pulsatile assist device. Postoperative macroscopic and microscopic findings demonstrated the smooth surface of the pump without thrombus formation. This centrifugal pump system might be useful for prolonged cardiopulmonary bypass.


Artif Organs


Artificial organs


Ninomiya J,Shoji T,Tanaka S,Ikeshita M,Ochi M,Yamauchi S,Yajima T,Yamauchi H,Sugimoto T,Aizawa T




Has Abstract


1994-09-01 00:00:00












  • Cadaver fitting study of the DexAide right ventricular assist device.

    abstract::The DexAide right ventricular assist device (RVAD) has been developed to provide an implantable RVAD option to surgeons. The aim of this study was to determine the optimal cannula design and optimal implantation location of the DexAide RVAD in preparation for its clinical use. Separately, a HeartMate XVE left ventricu...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ootaki Y,Ootaki C,Kamohara K,Akiyama M,Cingoz F,Kopcak MW Jr,Dessoffy R,Liu J,Massiello A,Horvath D,Chen JF,Zhou Q,Benefit S,Golding LA,Fukamachi K

    更新日期:2007-08-01 00:00:00

  • Comparison of rapid in situ, regular in situ, and ex vivo flushing on hepatic function.

    abstract::The efficacy of three flushing techniques on subsequent liver function was assessed using the in vivo isolated liver perfusion model (ILPM). Livers from brain-dead mongrel dogs were flushed with cold Euro-Collins as follows: Group I, rapid in situ flushing (10 min); Group II, regular in situ flushing (45 min); Group I...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Castellanos J,Toledo-Pereyra LH,Finkelstein I,Kestenberg W,Chapman M,Choudhury S

    更新日期:1988-06-01 00:00:00

  • The human genome efforts and the cDNA project.

    abstract::Molecular biology has been moving swiftly toward clarifying the entire genome of organisms, including human. The human genome efforts that promote this transaction are characterized by the large-scale, high throughput production of data about the structure of the genome of the molecular level and its computer-assisted...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审


    authors: Matsubara K

    更新日期:1996-08-01 00:00:00

  • Development of high-efficiency molecular adsorbent recirculating system: preliminary report.

    abstract::Molecular Adsorbent Recirculating System (MARS) is a liver support system widely employed in the treatment of liver failure. The method is normally well tolerated. To develop a liver support system combining high efficiency and tolerability, we modified the MARS albumin circuit with the insertion of double adsorption ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Marangoni R,Bellati G,Castelli A,Romagnoli E

    更新日期:2014-10-01 00:00:00

  • Serum hyaluronic acid and interleukin-6 as possible markers of carpal tunnel syndrome in chronic hemodialysis patients.

    abstract::To elucidate the precise mechanism of carpal tunnel syndrome (CTS), serum hyaluronic acid (HA), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were measured in 71 chronic hemodialysis patients with or without CTS and/or shoulder pain. Patients were divided into two gr...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Takasu S,Takatsu S,Kunitomo K,Kokumai Y

    更新日期:1994-06-01 00:00:00

  • Acellular Endocardium as a Novel Biomaterial for the Intima of Tissue-Engineered Small-Caliber Vascular Grafts.

    abstract::We aimed to investigate whether acellular endocardium can be used as a useful biomaterial for the intima of engineered small-caliber vascular grafts. Fresh endocardium was harvested from the swine left atrium and was decellularized by digestion with the decellularization solution of Triton X-100 and SDS containing DNa...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Wang F,Guan X,Wu T,Qiao J,Han Z,Wu J,Yu X,You Q

    更新日期:2016-12-01 00:00:00

  • Differential functional coupling between human saphenous cryoallografts and arteries: importance of the arterial type and the biomechanical parameter evaluated.

    abstract::The aim of this study was to characterize and compare human great saphenous veins (HGSVs), HGSV cryoallografts, expanded polytetrafluoroethylene (ePTFE) segments, and elastic and muscular arteries' biomechanics, so as to identify if the biomechanical coupling and the HGSV advantages with respect to ePTFE depend on the...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Bia D,Zócalo Y,Pessana F,Armentano R,Pérez H,Saldías M,Alvarez I

    更新日期:2007-11-01 00:00:00

  • Biodegradation and biocompatibility of polyorganophosphazene.

    abstract::We investigated biodegradation and biocompatibility of poly(organophosphazenes). We prepared poly(organophosphazenes) having different side chain groups. The blood compatibility of poly(organophosphazenes) containing fluorinated side groups, poly(bis[trifluoroethoxy]phosphazene) (PbFP) and poly([trifluoroethoxy][ethyl...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Kawakami H,Kanezaki S,Sudo M,Kanno M,Nagaoka S,Kubota S

    更新日期:2002-10-01 00:00:00

  • Hemodynamic evaluation of a new left ventricular assist device: an integrated cardioassist catheter as a pulsatile left ventricle-femoral artery bypass.

    abstract::We developed a new left ventricular (LV) assist catheter (transaortic valve from LV to femoral artery) that is implemented percutaneously and exerted as a synchronous pulsatile partial LV flow support with conventional intraaortic balloon pump (IABP) driving system and centrifugal pump system. We investigated whether ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Ide H,Yamaguchi A,Ino T,Matsumoto H,Fujimasa I

    更新日期:1992-06-01 00:00:00

  • Influence of different hemodialysis membranes on red blood cell susceptibility to oxidative stress.

    abstract::Oxidative stress is crucial in red blood cell (RBC) damage induced by activated neutrophils in in vitro experiments. The aim of the study was to evaluate whether the bioincompatibility phenomena occurring during hemodialysis (HD) (where neutrophil activation with increased free radical production is well documented) m...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Lucchi L,Bergamini S,Botti B,Rapanà R,Ciuffreda A,Ruggiero P,Ballestri M,Tomasi A,Albertazzi A

    更新日期:2000-01-01 00:00:00

  • Simple evaluation method of biocompatibility of artificial oxygenator hollow fiber.

    abstract::We made miniature modules filled with artificial oxygenator hollow fibers and conducted a simple experiment to study the effect of different membrane structures on the blood. Three types of modules were made: one filled with polyolefin, one filled with polypropylene, and a blank module. The 3 modules were connected th...

    journal_title:Artificial organs

    pub_type: 临床试验,杂志文章


    authors: Nishida H,Shibuya M,Endo M,Koyanagi H

    更新日期:1996-12-01 00:00:00

  • Clinical use of low porosity woven ultrafine polyester fiber grafts.

    abstract::A woven fabric graft made of ultrafine polyester fibers (UFPF) (Toray Graft, water porosity: 100 ml/min/cm2:120 mm Hg H2O) was clinically applied in 81 cases (28 thoracic aortic aneurysms, 6 thoracoabdominal aortic aneurysms, 42 abdominal aortic aneurysms, and 5 atherosclerotic obstructions of the peripheral arteries)...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Satoh S,Niu S,Kanda K,Hirai J,Nakazima S,Wada Y,Oka T,Noishiki Y

    更新日期:1995-01-01 00:00:00

  • Numerical simulations of blood flow in artificial and natural hearts with fluid-structure interaction.

    abstract::This article describes two ongoing numerical studies of fluid-structure interaction in the cardiovascular system: an idealized pulsatile ventricular assist device (VAD), consisting of two fluid chambers separated by a flexible diaphragm; and blood flow and heart wall motion during passive filling of a canine heart. Si...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Doyle MG,Vergniaud JB,Tavoularis S,Bourgault Y

    更新日期:2008-11-01 00:00:00

  • Dialyzer membranes: effect of surface area and chemical modification of cellulose on complement and platelet activation.

    abstract::Using an ex vivo model, the effects of membrane composition and surface area on both the complement system (as reflected by plasma C3a levels) and platelets [as indicated by plasma concentrations of thromboxane B2 (TXB2) and platelet factor 4 (PF4)] were studied. In this model, polyacrylonitrile (PAN) was associated w...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Mahiout A,Meinhold H,Kessel M,Schulze H,Baurmeister U

    更新日期:1987-04-01 00:00:00

  • Reduction of driveline infections through doubled driveline tunneling of left ventricular assist devices.

    abstract::The durability of ventricular assist device (VAD) therapy improved steadily over the past years. However, driveline infections remain a challenge. To test whether an improved surgical implantation technique may lower the incidence of infections, we analyzed all patients receiving a VAD implantation in the years 2008 a...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Fleissner F,Avsar M,Malehsa D,Strueber M,Haverich A,Schmitto JD

    更新日期:2013-01-01 00:00:00

  • Effect of filtration leukocytapheresis therapy: modulation of white blood cell enzyme activities in patients with rheumatoid arthritis.

    abstract::We treated 12 patients with rheumatoid arthritis by filtration leukocytapheresis (FLCP) and evaluated its effect on leukocyte enzyme activities. We calculated the number of leukocytes removed and assessed the clinical response. We also evaluated the cellular enzyme activities of elastase and dipeptidylpeptidase IV (DP...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Yamasaki S,Ueki Y,Nakamura H,Yano M,Matsumoto K,Miyake S,Tominaga T,Tominaga M,Eguchi K

    更新日期:2002-04-01 00:00:00

  • Extracorporeal Life Support in Out-of-Hospital Refractory Cardiac Arrest.

    abstract::Out-of-Hospital refractory Cardiac Arrest (OHrCA) has a mortality rate between 90 and 95%. Since 2009, French medical academic societies have recommended the use of extracorporeal life support (ECLS) for OHrCA. According to these guidelines, patients were eligible for ECLS support if vital signs were still present dur...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Rousse N,Robin E,Juthier F,Hysi I,Banfi C,Al Ibrahim M,Coadou H,Goldstein P,Wiel E,Vincentelli A

    更新日期:2016-09-01 00:00:00

  • Magnevad status of design improvements human blood results and preliminary sheep trial.

    abstract::Magnevad II is an improved version of Magnevad I and both are fourth-generation axial flow left ventricular assist devices. A major simplification has been implemented and tested. Magnevad I used a magnetically suspended rotor requiring active axial control. Magnevad II is completely passive but otherwise similar. A s...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Goldowsky M,Lafaro R,Reed G

    更新日期:2005-10-01 00:00:00

  • Intermittent stops of shear reduce the mechanical damage of red blood cells.

    abstract::Continuous and intermittent high shear were loaded to red blood cells in a cone and a plate rheoscope. The mechanical damage to red cells was compared for continuous and intermittent shear. The intermittent shear was achieved by alternately starting and stopping shear repeatedly. In the case of intermittent shear load...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Mizunuma H,Sakai S

    更新日期:2007-06-01 00:00:00

  • Development of a Tissue-Engineered Artificial Ligament: Reconstruction of Injured Rabbit Medial Collateral Ligament With Elastin-Collagen and Ligament Cell Composite Artificial Ligament.

    abstract::Ligament reconstruction using a tissue-engineered artificial ligament (TEAL) requires regeneration of the ligament-bone junction such that fixation devices such as screws and end buttons do not have to be used. The objective of this study was to develop a TEAL consisting of elastin-coated polydioxanone (PDS) sutures c...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Hirukawa M,Katayama S,Sato T,Inoue K,Niwa K,Ito N,Hattori T,Hosoi T,Unno H,Suzuki Y,Hasegawa M,Miyamoto K,Horiuchi T

    更新日期:2018-07-01 00:00:00

  • In vivo test of pressure head and flow rate estimation in a continuous-flow artificial heart.

    abstract::To avoid using sensors with low biocompatibility and low durability in implantable total artificial heart (TAH) systems, the authors previously proposed a new method for estimating instantaneous values of flow rate and pressure head on the basis of voltage, current, and rotational speed in a motor driven centrifugal p...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Tanaka A,Yoshizawa M,Abe K,Takeda H,Yambe T,Nitta S

    更新日期:2003-01-01 00:00:00

  • The pivot wash in two impeller modes for the Baylor/Miwatec centrifugal blood pump.

    abstract::A centrifugal blood pump with a double pivot impeller and an eccentric inlet port is being developed as an implantable artificial heart by the Baylor College of Medicine and Miwatec Co. Ltd. Flow visualization measurements were conducted to compare the flow around the pivot for two impeller operational modes: the top ...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Yamane T,Kodama T,Nishida M,Maruyama O,Yamamoto Y,Shinohara T,Motomura T,Nosé Y

    更新日期:2006-01-01 00:00:00

  • Belt worn control system and battery for the percutaneous model of the Jarvik 2000 heart.

    abstract::A belt worn controller and lithium-ion battery pack have been developed for use with the initial clinical trials of the Jarvik 2000 heart. Patient interface considerations, safety, and simplicity were major design inputs for the system. The controller was developed using all analog technology to avoid difficulties wit...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Jarvik R,Scott V,Morrow M,Takecuhi E

    更新日期:1999-06-01 00:00:00

  • Substantial early loss of induced pluripotent stem cells following transplantation in myocardial infarction.

    abstract::The limited success of cardiac stem cell therapy has lately generated discussion regarding its effectiveness. We hypothesized that immediate cell loss after intramyocardial injection significantly obscures the regenerative potential of stem cell therapy. Therefore, our aim was to assess the distribution and quantity o...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Martens A,Rojas SV,Baraki H,Rathert C,Schecker N,Zweigerdt R,Schwanke K,Rojas-Hernandez S,Martin U,Saito S,Schmitto JD,Haverich A,Kutschka I

    更新日期:2014-11-01 00:00:00

  • Renal osteodystrophy in dialysis patients: diagnosis and treatment.

    abstract::This article reviews the clinical, biological, radiological, and pathological procedures and their respective indications for the practical diagnosis of the following various histological patterns of renal osteodystrophy: osteitis fibrosa due to parathyroid hormone (PTH) hypersecretion: osteomalacia or rickets due to ...

    journal_title:Artificial organs

    pub_type: 杂志文章,评审


    authors: Fournier A,Oprisiu R,Hottelart C,Yverneau PH,Ghazali A,Atik A,Hedri H,Said S,Sechet A,Rasolombololona M,Abighanem O,Sarraj A,El Esper N,Moriniere P,Boudailliez B,Westeel PF,Achard JM,Pruna A

    更新日期:1998-07-01 00:00:00

  • Progress in the control system of the undulation pump total artificial heart.

    abstract::The undulation pump total artificial heart (UPTAH) is a small implantable total artificial heart. As the UPTAH generates outflow and inflow at the same time, control of the UPTAH is very difficult. Therefore suitable control methods specifically for the UPTAH should be established. Various motor control, left-right fl...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Saito I,Chinzei T,Abe Y,Ishimaru M,Mochizuki S,Ono T,Isoyama T,Iwasaki K,Kouno A,Baba A,Ozeki T,Takiura K,Tohyama T,Nakagawa H,Imachi K

    更新日期:2003-01-01 00:00:00

  • Technical feasibility of umbilical cannulation in midgestation lambs supported by the EXTra-uterine Environment for Neonatal Development (EXTEND).

    abstract::EXTEND (EXTra-uterine Environment for Neonatal Development) is a novel system for supporting extremely premature infants that replicates in utero conditions by maintaining a sterile fluid environment and providing gas exchange via a pumpless arteriovenous oxygenator circuit connected to the umbilical vessels. Target g...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Hornick MA,Mejaddam AY,McGovern PE,Hwang G,Han J,Peranteau WH,Partridge EA,Davey MG,Flake AW

    更新日期:2019-12-01 00:00:00

  • Assessment of skeletal muscle ventricle tissue blood flow using positron emission tomography.

    abstract::In this pilot study, we assessed the feasibility of using positron emission tomography (PET) imaging for in vivo measurement of skeletal muscle ventricle (SMV) tissue blood flow. In 4 dogs, with SMVs prepared from their latissimus dorsi muscle, we quantified SMV tissue blood flow by PET and related it to the tissue fl...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Singh TP,Greer K,Muzik O,Hammond RL,Stephenson LW,Di Carli MF

    更新日期:2001-04-01 00:00:00

  • Use of hemoperfusion in experimental intoxication with nerve agents.

    abstract::The aim of this study was to evaluate the efficiency of hemoperfusion (HP) through coated resin adsorbent Synachrom E-5 in animal intoxications with organophosphate inhibitors of cholinesterases type of nerve agents. Five anesthetized dogs were intoxicated with 2 to 6 LD50 of VX substance and another 4 with 2 to 3 LD5...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Monhart V,Fusek J,Brndiar M,Tlustakova M

    更新日期:1994-10-01 00:00:00

  • Double filtration plasmapheresis for the treatment of rheumatoid arthritis: a study of 21 cases.

    abstract::The treatment of rheumatoid arthritis remains difficult and often controversial. Plasma exchange has been advocated in some cases. In the present study 71 sessions of double filtration plasmapheresis (DFPP) were performed in 21 patients with rheumatoid arthritis in an average of 3.7 +/- 1.1 sessions per patient within...

    journal_title:Artificial organs

    pub_type: 杂志文章


    authors: Liu JD,Zhang C,Li WS,Lun LD

    更新日期:1997-02-01 00:00:00