The role of PI3K/Akt signaling pathway in non-physiological shear stress-induced platelet activation.

abstract：:A 68-year-old woman with fulminant hepatic failure of unknown etiology was treated with a bioartificial liver assist device. Prior to treatment, she had a number of clinical and laboratory features that suggested a hopeless outcome. Treatment was associated with a dramatic change in her mental status, and her clinical...

journal_title：Artificial organs

authors： Sussman NL,Kelly JH

更新日期：1993-01-01 00:00:00

abstract：:A compact three-dimensional (3D) module is needed for hepatocyte culture in order to develop an effective hybrid artificial liver system that can retain hepatocellular structure and differentiated functions. We treated the 3D module with collagen gel to entrap rat hepatocytes. This method yielded a high hepatocellular...

journal_title：Artificial organs

authors： Takeshita K,Ishibashi H,Suzuki M,Yamamoto T,Akaike T,Kodama M

更新日期：1995-02-01 00:00:00

abstract：:Nonpulsatile blood pumps are mainly used in extracorporeal life support systems. Although pulsating blood flow is known to be physiological, a pulsatile pump is not commonly applied in a circuit with a membrane oxygenator because of damage to the blood cells. The hypothesis that the placement of a pressure-relieving c...

journal_title：Artificial organs

authors： Kim TS,Sun K,Lee KB,Lee HW,Baek KJ,Park SY,Son HS,Kim KT,Kim HM

更新日期：2004-12-01 00:00:00

abstract：:A dynamic flow type testing to study calcification was self-designed to investigate calcification in bioprosthetic heart valves. The apparatus consists of a container into which leaflets from a porcine aortic valve are placed, a chamber that contains calcium solution, and a peristaltic pump that provides a continuous ...

journal_title：Artificial organs

authors： Park JC,Hwang YS,Han DW,Suh H

更新日期：2000-02-01 00:00:00

abstract：:Porous polyurethane (nonwoven) was used for the development of tracheal prosthesis, which--in a special testing design--was adapted to shape and biomechanic properties of the natural organ. This prosthesis was implanted into 19 beagle dogs using inverted, everted, and end-to-end anastomosis. Insufficiency of the anast...

journal_title：Artificial organs

authors： Schauwecker HH,Gerlach J,Planck H,Bücherl ES

更新日期：1989-06-01 00:00:00

abstract：:To date, single-needle (SN) hemodialysis (HD) requires a dialysis machine equipped with two blood pumps-one controlling arterial blood flow (Qb) and one controlling venous Qb. B. Braun has developed an innovative single-pump SN HD system. Therefore, usability is improved by reducing complexity. The aim of this study w...

journal_title：Artificial organs

authors： Bieser W,Welsch M,Jakob M,Meibaum J,Rodriguez DA,Wolff H,Marcelli D,Barth C

更新日期：2018-08-01 00:00:00

abstract：:Pharmacologic agents and other non-protein-bound compounds smaller than 5,000 daltons have the potential to be removed by continuous arteriovenous hemofiltration (CAVH). A proposed method for estimating drug clearance by CAVH (ClCAVH) equates ultrafiltrate clearance to the product of the sieving coefficient and the av...

journal_title：Artificial organs

authors： Horton MW,Godley PJ,Moore ES,Fineg J,Gillespie WR

更新日期：1990-12-01 00:00:00

abstract：:This study compares the effects of polyethylene glycol (PEG) modified bovine hemoglobin on vascular half-life and renal function in rabbits to those of unmodified bovine hemoglobin. Renal function was assessed by the measurement of the glomerular filtration rate, urinalysis, blood chemistries, hemoglobin (Hb) excretio...

journal_title：Artificial organs

authors： Conover CD,Gilbert CW,Shum KL,Shorr RG

更新日期：1997-08-01 00:00:00

abstract：:In vitro cardiovascular device performance evaluation in a mock circulation loop (MCL) is a necessary step prior to in vivo testing. A MCL that accurately represents the physiology of the cardiovascular system accelerates the assessment of the device's ability to treat pathological conditions. To serve this purpose, a...

journal_title：Artificial organs

authors： Timms DL,Gregory SD,Greatrex NA,Pearcy MJ,Fraser JF,Steinseifer U

更新日期：2011-04-01 00:00:00

abstract：:Albumin-coated Amberlite XAD-7 has been previously shown to be blood compatible in in vitro hemoperfusion experiments whith human blood. In this study, the preliminary results are reported on single hemoperfusions with albumin-coated XAD-7 resin in four patients with acute liver failure. The mean platelet count was 11...

journal_title：Artificial organs

authors： Hughes R,Ton HY,Langley P,Davies M,Hanid MA,Mellon P,Silk DB,Williams R

更新日期：1979-02-01 00:00:00

abstract：:Our aim was to study the feasibility of implanting the Infant Jarvik 2015 in patients weighing less than 8 kg. The Infant Jarvik 2015 left ventricular assist device (LVAD) was tested in a hybrid simulator of the cardiovascular system reproducing specific patients' hemodynamics for different patient weights (2-7 kg). F...

journal_title：Artificial organs

authors： Di Molfetta A,Zielinski K,Ferrari G,Kozarski M,Okrzeja P,Iacobelli R,Filippelli S,Perri G,Darowski M,Massetti M,Jarvik R,Amodeo A

更新日期：2019-01-01 00:00:00

abstract：:Different from the existing tissue engineering strategies, rapid prototyping (RP) techniques aim to automatically produce complex organs directly from computer-aided design freeform models with high resolution and sophistication. Analogous to building a nuclear power plant, cell biology (especially, renewable stem cel...

journal_title：Artificial organs

authors： Wang X

更新日期：2012-11-01 00:00:00

abstract：:To evaluate the potential clinical usefulness of a modified hemoglobin, pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), the hindlimb vascular bed was perfused with PHP solution while monitoring tissue oxygen tension (PtO2) in anesthetized dogs. The hindlimb region was perfused through the external iliac arte...

journal_title：Artificial organs

authors： Kida Y,Yamakawa T,Iwasaki S,Furusho N,Kadowaki Y,Iwata S,Iwashita Y,Nishi K

更新日期：1995-06-01 00:00:00

abstract：:Controlled and repeatable in vitro evaluation of cardiovascular devices using a mock circulation loop (MCL) is essential prior to in vivo or clinical trials. MCLs often consist of only a systemic circulation with no autoregulatory responses and limited validation. This study aimed to develop, and validate against huma...

journal_title：Artificial organs

authors： Gregory SD,Pauls JP,Wu EL,Stephens A,Steinseifer U,Tansley G,Fraser JF

更新日期：2020-06-01 00:00:00

abstract：:The polymer poly(ε-caprolactone) (PCL) has been used in the biomaterial field for its relatively inexpensive price and suitability for modification. Also, its chemical and biological properties are desirable for biomedical applications. The electrospinning process has been used for producing polymer fibers of PCL due ...

journal_title：Artificial organs

authors： Capellato P,Silva G,Popat K,Simon-Walker R,Alves Claro AP,Zavaglia C

更新日期：2020-08-01 00:00:00

abstract：:The power-law based models for predicting shear-induced hemolysis are widely used in the optimization design of blood-contacting devices. However, this category of models has fallen short of accuracy when compared with the results of the in vitro experiments. The aim of this study is to develop an alternative model fr...

journal_title：Artificial organs

authors： Li H,Ruan X,Qian W,Fu X

更新日期：2014-12-01 00:00:00

abstract：:The treatment of rheumatoid arthritis remains difficult and often controversial. Plasma exchange has been advocated in some cases. In the present study 71 sessions of double filtration plasmapheresis (DFPP) were performed in 21 patients with rheumatoid arthritis in an average of 3.7 +/- 1.1 sessions per patient within...

journal_title：Artificial organs

authors： Liu JD,Zhang C,Li WS,Lun LD

更新日期：1997-02-01 00:00:00

abstract：:To develop an effective hybrid bioartificial liver (BAL) device, the material of the scaffold is very important to support hepatocytes that have both growth ability and hepatic differentiated functions. In this study we used paper (Kimwipe, Kimberly-Clark Corp., Roswell, GA, U.S.A.) as a scaffold. Primary hepatocytes ...

journal_title：Artificial organs

authors： Mizuguchi T,Mitaka T,Sato F,Mochizuki Y,Hirata K

更新日期：2000-04-01 00:00:00

abstract：:Tissue responses to various percutaneous materials with different surface properties and structures were investigated. Dense hydroxyapatite (HA), tricalcium phosphate (TCP), glassy carbon (GC), and 2 types of porous HA were used. Cutaneous and subcutaneous tissues were tightly attached to the surface of the penetratin...

journal_title：Artificial organs

authors： Shin Y,Akao M

更新日期：1997-09-01 00:00:00

abstract：:Secondary flow in the centrifugal blood pump helps to enhance the washout effect and to minimize thrombus formation. On the other hand, it has an adverse effect on pump efficiency. Excessive secondary flow may induce hemolytic effects. Understanding the secondary flow is thus important to the design of a compact, effi...

journal_title：Artificial organs

authors： Watanabe N,Masuda T,Iida T,Kataoka H,Fujimoto T,Takatani S

更新日期：2005-01-01 00:00:00

abstract：:Spiral/helical forms of blood flow have been observed in large arteries of the cardiovascular system, but their benefits remain underappreciated. Spiral flow has been postulated to improve near-wall washout, promoting anti-atherothrombotic conditions. This research aims to study the washout characteristics of spiral f...

journal_title：Artificial organs

authors： Huang Zhang P,Tkatch C,Newman R,Grimme W,Vainchtein D,Kresh JY

更新日期：2019-12-01 00:00:00

abstract：:The aim of this study was to verify if dialysis solution volumes used in patients on continuous ambulatory peritoneal dialysis (CAPD) interfere with pulmonary function and if the pulmonary volumes interfere with the lymphatic absorption of the peritoneal cavity. We submitted 10 CAPD patients with a mean age of 48 +/- ...

journal_title：Artificial organs

authors： Marmanillo CG,Pecoits-Filho RF,Romão JE Jr,Kakehashi ET,Sabbaga E,Marcondes M,Abensur H

更新日期：2001-11-01 00:00:00

abstract：:Thirteen percent of 99 patients undergoing maintenance hemodialysis showed an increased predialysis peripheral blood eosinophil count (mean value of 828 cells/mm3, range 410-2,710). Patients with eosinophilia were predominantly male and evidenced more frequent elevation of total plasma IgE levels. Otherwise, no differ...

journal_title：Artificial organs

authors： Friedberg M,Joffe P,Nielsen B,Nielsen LP

更新日期：1987-04-01 00:00:00

abstract：:The aim of this study was to characterize and compare human great saphenous veins (HGSVs), HGSV cryoallografts, expanded polytetrafluoroethylene (ePTFE) segments, and elastic and muscular arteries' biomechanics, so as to identify if the biomechanical coupling and the HGSV advantages with respect to ePTFE depend on the...

journal_title：Artificial organs

authors： Bia D,Zócalo Y,Pessana F,Armentano R,Pérez H,Saldías M,Alvarez I

更新日期：2007-11-01 00:00:00

abstract：:An increasing amount of evidence points to cerebral embolization during cardiopulmonary bypass (CPB) as the principal etiologic factor of neurologic complications. In this study, the capability of capturing and classification of gaseous emboli and pressure drop of three different membrane oxygenators (Sorin Apex, Teru...

journal_title：Artificial organs

authors： Guan Y,Palanzo D,Kunselman A,Undar A

更新日期：2009-11-01 00:00:00

abstract：:Methods to predict and control cardiac output (CO) accurately in total artificial heart (TAH) recipients have varied significantly in the last few decades. Early models exhibited minimal control mechanisms and involved fixed pumping parameters. Elaborate electromechanical systems that have recently evolved require int...

journal_title：Artificial organs

authors： White RK,Olsen DB

更新日期：1991-10-01 00:00:00

abstract：:Left ventricular assist devices (LVADs) are increasingly being used as life-saving therapy in patients with end-stage heart failure. The changes in spirometry following LVAD implantation and subsequent unloading of the left ventricle and pulmonary circulation are unknown. In this study, we explored long-term changes i...

journal_title：Artificial organs

authors： Mohamedali B,Bhat G,Yost G,Tatooles A

更新日期：2015-12-01 00:00:00

abstract：:Patients receiving mechanical circulatory support often present with heightened inflammation and free radical production associated with pre-existing conditions in addition to that which is due to blood interactions with nonbiological surfaces. The aim of this experimental laboratory study was to assess the deformabil...

journal_title：Artificial organs

authors： McNamee AP,Horobin JT,Tansley GD,Simmonds MJ

更新日期：2018-02-01 00:00:00

abstract：:Fibroblast cell culture was performed to evaluate cell adhesion and cell morphology on novel hydrolyzable copolymers composed of poly(D,L-lactic acid) (PDLA) macromonomer, 2-methacryloyloxyethyl phosphorylcholine (MPC), and n-butyl methacrylate. The copolymers were used as cell culture materials for regulating the int...

journal_title：Artificial organs

authors： Watanabe J,Ishihara K

更新日期：2003-03-01 00:00:00

abstract：:Recently, there has been an increase in the use of rat models of cardiopulmonary bypass (CPB) for research purposes. Much of this work has focused on cerebral injury associated with CPB. Many of these studies employ a peripheral cannulation approach, often utilizing the caudal artery and internal or external jugular v...

journal_title：Artificial organs

authors： Gourlay T,Modine T

更新日期：2010-06-01 00:00:00