Abstract:
:The objective of this study was to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of two pediatric oxygenators in a simulated pediatric cardiopulmonary bypass (CPB) model and the importance of adding an arterial filter in the circuit. The circuit consisted of a Braile Infant oxygenator or a Maquet Quadrox-I Pediatric oxygenator without integrated arterial filter (parallel arrangement), 1/4 in. ID tubing A-V loop, and a 12-Fr arterial cannula, primed with lactated Ringer's solution and packed red blood cells. Trials were conducted at flow rates ranging from 500 to 2000 mL/min (500 mL/min increment) at 35°C and 28°C. Real-time pressure and flow data were recorded using a custom-based data acquisition system. For GME testing, 5 cc of air was manually injected into the venous line. GME were recorded using the Emboli Detection and Classification Quantifier (EDAC) System. An additional experiment using a separate arterial filter was conducted. There was no difference in the mean circuit pressure, pressure drop, total hemodynamic energy level, and energy loss between the two oxygenators. The venous line pressures were higher in the Braile than in the Quadrox group during all trials (P <0.01). GME count and volume at pre-/post oxygenator and pre-cannula sites in the Quadrox were lower than the Braile group at high flow rates (P < 0.05). In the additional experiment, an arterial filter captured a significant number of microemboli at all flow rates. The Braile Infant oxygenator has a matched hemodynamic characteristic with the Quadrox-i Pediatric oxygenator. The Quadrox-i has a better GME handling ability compared with the Braile Infant oxygenator. Regardless of type of oxygenator an additional arterial filter decreases the number of GME.
journal_name
Artif Organsjournal_title
Artificial organsauthors
Wang S,Caneo LF,Jatene MB,Jatene FB,Cestari IA,Kunselman AR,Ündar Adoi
10.1111/aor.12912subject
Has Abstractpub_date
2017-09-01 00:00:00pages
865-874issue
9eissn
0160-564Xissn
1525-1594journal_volume
41pub_type
杂志文章,多中心研究abstract::Bovine pericardium is a widely utilized biomaterial. Usually, after harvesting, it is advantageous that the pericardium be immersed in glycerol to improve its shelf life. This can induce some degree of toxicity in the material. The studies were performed in compliance with the rules of ISO 10993 and OECD 487, in the b...
journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2008.00565.x
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.2009.00894.x
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journal_title:Artificial organs
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Artificial organs
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journal_title:Artificial organs
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1978-11-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/aor.13768
更新日期:2020-07-09 00:00:00
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pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
doi:10.1111/j.1525-1594.1988.tb02813.x
更新日期:1988-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Artificial organs
pub_type: 杂志文章
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更新日期:1994-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Artificial organs
pub_type: 杂志文章
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journal_title:Artificial organs
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