Abstract:
:The hippocampus is a crucial player across several learning and memory domains, and is highly vulnerable to alterations during aging. Several products of neurotransmitter genes and neuromodulator genes (which play important parts in mediating and maintaining cognitive ability as a function of age) are expressed in hippocampal formation. However, they represent only a small fraction of genes known to be expressed in this region. We review here recent studies on the use of cDNA microarray and proteomic approaches to uncover novel genes and pathways that might be involved in cognitive processes in the aged brain. We and other authors have demonstrated major individual differences in cognitive ability in rats of a similar age, thereby making it possible to directly compare gene products expressed as a function of age and cognitive status. Examples of the possible functional role of some of these genes (e.g. transthyretin, quinone reductase 2) and gene products are discussed.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Benoit CE,Rowe WB,Menard C,Sarret P,Quirion Rdoi
10.1016/j.tips.2010.10.002subject
Has Abstractpub_date
2011-01-01 00:00:00pages
43-52issue
1eissn
0165-6147issn
1873-3735pii
S0165-6147(10)00189-6journal_volume
32pub_type
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