Modalities for reducing interleukin 1 activity in disease.

Abstract:

:The therapeutic advantage of reducing the activity of interleukin 1 (IL-1) resides in preventing its deleterious biological effects without interfering with homeostasis. As such, methods attempting to block the production or activity of IL-1 have now entered clinical trials. For example, IL-1 induction of prostaglandins is one target in treating disease, and drugs preventing the production of inhibiting cyclooxygenase have well-known toxicities because they block the normal synthesis of prostaglandins in many tissues. IL-1 blockading agents, in contrast, affect only that portion of prostaglandin synthesis due to elevated IL-1, sparing the synthesis of these molecules for homeostasis. Charles Dinarello reviews the unique pharmacological advantages of manipulating IL-1.

journal_name

Trends Pharmacol Sci

authors

Dinarello CA

doi

10.1016/0165-6147(93)90200-4

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

155-9

issue

5

eissn

0165-6147

issn

1873-3735

pii

0165-6147(93)90200-4

journal_volume

14

pub_type

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