Abstract：
:Hormesis is a generalizable dose-response relationship characterized by low-dose stimulation and high-dose inhibition. Despite debate over this biphasic dose-response curve, hormesis is challenging central beliefs in the evaluation of chemicals or drugs and has influenced biological model selection, concentration range, study design, and hypothesis testing. We integrate the traditional Chinese philosophy - Yin/Yang doctrine - into the representation of the Western hormetic dose-response relationship and review the Yin/Yang historical philosophy contained in the hormesis concept, aiming to promote general acceptance and wider applications of hormesis. We suggest that the Yin/Yang doctrine embodies the hormetic dose-response, including the relationship between the opposing components, curve shape, and time-dependence, and may afford insights that clarify the hormetic dose-response relationship in toxicology and pharmacology.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Sun H,Calabrese EJ,Lin Z,Lian B,Zhang Xdoi
10.1016/j.tips.2020.05.004subject
Has Abstractpub_date
2020-08-01 00:00:00pages
544-556issue
8eissn
0165-6147issn
1873-3735pii
S0165-6147(20)30128-0journal_volume
41pub_type
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