Abstract:
:It is now established that most of the approximately 800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation, however, does not provide an adequate mechanism for the control of tissue-specific GPCR signalling. Here, we review the evidence that GPCR phosphorylation is, in fact, a flexible and dynamic regulatory process in which GPCRs are phosphorylated in a unique manner that is associated with the cell type in which the receptor is expressed. In this scenario, phosphorylation offers a mechanism of regulating the signalling outcome of GPCRs that can be tailored to meet a specific physiological role.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Tobin AB,Butcher AJ,Kong KCdoi
10.1016/j.tips.2008.05.006subject
Has Abstractpub_date
2008-08-01 00:00:00pages
413-20issue
8eissn
0165-6147issn
1873-3735pii
S0165-6147(08)00140-5journal_volume
29pub_type
杂志文章,评审abstract::The rise of multidrug-resistant pathogens and the dearth of new antibiotic development place an existential strain on successful infectious disease therapy. Breakthrough strategies that go beyond classical antibiotic mechanisms are needed to combat this looming public health catastrophe. Reconceptualizing antibiotic t...
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