p53 Throws CRISPR a Curve.

Abstract:

:The efficacy of the powerful CRISPR-Cas9 genome-editing platform depends on DNA repair activities in the cells being targeted. Two new papers show that the low efficiency of targeting in some primary human cell lines is the result of p53-dependent cell arrest in response to the Cas9-induced break. This limitation must be overcome for some anticipated therapies.

journal_name

Trends Pharmacol Sci

authors

Carroll D

doi

10.1016/j.tips.2018.06.005

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

783-784

issue

9

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(18)30104-4

journal_volume

39

pub_type

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