The hypothalamic H1 receptor: a novel therapeutic target for disrupting diurnal feeding rhythm and obesity.

Abstract:

:Histamine-containing neurons and histamine H1 receptors are distributed within the brain and peripheral tissues. The results of physiological and pharmacological studies have revealed that brain histamine and H1 receptors are involved in the regulation of feeding and obesity in rodents. The adipocytokine leptin regulates feeding and obesity, partially through brain histamine. Furthermore, recent studies have provided evidence that regulation of the diurnal rhythm of feeding through H1 receptors is a crucial factor in the development of obesity. Thus, the regulation of H1 receptors is important for the control of energy metabolism, feeding rhythms and obesity in rodents.

journal_name

Trends Pharmacol Sci

authors

Masaki T,Yoshimatsu H

doi

10.1016/j.tips.2006.03.008

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

279-84

issue

5

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(06)00082-4

journal_volume

27

pub_type

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