Abstract:
:Neuronal Ca2+-sensor (NCS) proteins constitute a subfamily of closely related EF-hand Ca2+-binding proteins that are expressed mainly in neurons or retinal photoreceptor cells. A variety of different neuronal functions have been attributed to these proteins. However, important new discoveries indicate that these proteins also have key roles in pathological processes of disease. Thus, a 'darker side' of NCS protein signaling has become evident in some CNS disorders, such as Alzheimer's disease and schizophrenia, and in cancer. In this article, I will provide an overview of the current, and rapidly expanding, knowledge of how this important family of proteins might be involved in various major CNS diseases, the proposed role of NCS proteins in pathophysiological signaling and the development of pharmacological tools and novel research strategies.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Braunewell KHdoi
10.1016/j.tips.2005.04.008subject
Has Abstractpub_date
2005-07-01 00:00:00pages
345-51issue
7eissn
0165-6147issn
1873-3735pii
S0165-6147(05)00109-4journal_volume
26pub_type
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