Subcellular Organization of GPCR Signaling.

Abstract:

:G protein-coupled receptors (GPCRs) comprise a large and diverse class of signal-transducing receptors that undergo dynamic and isoform-specific membrane trafficking. GPCRs thus have an inherent potential to initiate or regulate signaling reactions from multiple membrane locations. This review discusses emerging insights into the subcellular organization of GPCR function in mammalian cells, focusing on signaling transduced by heterotrimeric G proteins and β-arrestins. We summarize recent evidence indicating that GPCR-mediated activation of G proteins occurs not only from the plasma membrane (PM) but also from endosomes and Golgi membranes and that β-arrestin-dependent signaling can be transduced from the PM by β-arrestin trafficking to clathrin-coated pits (CCPs) after dissociation from a ligand-activated GPCR.

journal_name

Trends Pharmacol Sci

authors

Eichel K,von Zastrow M

doi

10.1016/j.tips.2017.11.009

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

200-208

issue

2

eissn

0165-6147

issn

1873-3735

pii

S0165-6147(17)30226-2

journal_volume

39

pub_type

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