Abstract：
:G protein-coupled receptors (GPCRs) comprise a large and diverse class of signal-transducing receptors that undergo dynamic and isoform-specific membrane trafficking. GPCRs thus have an inherent potential to initiate or regulate signaling reactions from multiple membrane locations. This review discusses emerging insights into the subcellular organization of GPCR function in mammalian cells, focusing on signaling transduced by heterotrimeric G proteins and β-arrestins. We summarize recent evidence indicating that GPCR-mediated activation of G proteins occurs not only from the plasma membrane (PM) but also from endosomes and Golgi membranes and that β-arrestin-dependent signaling can be transduced from the PM by β-arrestin trafficking to clathrin-coated pits (CCPs) after dissociation from a ligand-activated GPCR.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
Eichel K,von Zastrow Mdoi
10.1016/j.tips.2017.11.009subject
Has Abstractpub_date
2018-02-01 00:00:00pages
200-208issue
2eissn
0165-6147issn
1873-3735pii
S0165-6147(17)30226-2journal_volume
39pub_type
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