Abstract：
:The alpha-adrenoceptor was subdivided into three subtypes: alpha 2A-, alpha 2B- and alpha 2C-adrenoceptors almost ten years ago. Since then, the search has been on to discover and develop subtype-selective agonists and antagonists, but as yet no major breakthrough has been made. In the past year, several strains of genetically engineered mice have become available, either overexpressing, totally lacking or expressing heavily modified alpha 2-adrenoceptor subtypes. Ewen MacDonald, Brian Kobilka and Mika Scheinin describe how these mice may be utilized to elucidate the physiological functions of the receptor subtypes and the properties of future subtype-selective drugs.
journal_name
Trends Pharmacol Scijournal_title
Trends in pharmacological sciencesauthors
MacDonald E,Kobilka BK,Scheinin Mdoi
10.1016/s0165-6147(97)01063-8subject
Has Abstractpub_date
1997-06-01 00:00:00pages
211-9issue
6eissn
0165-6147issn
1873-3735pii
S0165-6147(97)01063-8journal_volume
18pub_type
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