Human cytochromes P450: problems and prospects.

Abstract:

:Cytochromes P450 are a superfamily of haem-containing monooxygenases. In mammals, two general classes of P450s exist: six families involved in steroid and bile acid biosynthetic pathways of metabolism; four families containing numerous individual P450s, mainly responsible for metabolism of foreign compounds. Many of the latter P450s, particularly those in the CYP2 family, exhibit a large degree of inter- and intra-species variability in regulation and catalytic activities. From a practical standpoint, these variabilities suggest the need for careful characterization of P450 catalytic activities and determination of P450 expression levels in humans. Human P450-based in vitro systems are being developed to evaluate drug and carcinogen metabolism.

journal_name

Trends Pharmacol Sci

authors

Gonzalez FJ

doi

10.1016/0165-6147(92)90107-h

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

346-52

issue

9

eissn

0165-6147

issn

1873-3735

pii

0165-6147(92)90107-H

journal_volume

13

pub_type

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